Evidence map›Paper›PMID 38235335›Full record

ArticleiScience2024

Growth-suppressor microRNAs mediate synaptic overgrowth and behavioral deficits in Fragile X mental retardation protein deficiency.

Megha Subramanian, William T Mills, Manish D Paranjpe, Uche S Onuchukwu, Manasi Inamdar, Amanda R Maytin, Xinbei Li, Joel L Pomerantz, Mollie K Meffert

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact, top 74% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 0 citations in OpenAlex.

  1. Review
  2. The Role of Estrogen in Brain MicroRNAs Regulation.Advanced pharmaceutical bulletin · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Megha SubramanianSolomon H. Snyder Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
William T MillsDepartment of Biological Chemistry, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Manish D ParanjpeDepartment of Biological Chemistry, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Uche S OnuchukwuDepartment of Biological Chemistry, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Manasi InamdarDepartment of Biological Chemistry, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Amanda R MaytinDepartment of Biological Chemistry, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Xinbei LiDepartment of Biological Chemistry, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Joel L PomerantzDepartment of Biological Chemistry, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Mollie K MeffertSolomon H. Snyder Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Johns Hopkins Medicine · USJohns Hopkins University · USLemuel Shattuck Hospital · US

Funding

Murine Mutagenesis CoreP30NS050274 · NINDS · JOHNS HOPKINS UNIVERSITY · PI KOLODKIN, ALEX L · 2005 to 2020
$10.9M
Defining post-transcriptional gene regulation in FMRP-deficiency usingmiRNA:target chimerasR01MH129292 · NIMH · JOHNS HOPKINS UNIVERSITY · PI MOLLIE Katherine MEFFERT · 2023 to 2026
$1.9M
Using microRNA-target chimeras to study post-transcriptional gene regulation in the mammalian CNSF31MH124282 · NIMH · JOHNS HOPKINS UNIVERSITY · PI MILLS, WILLIAM THOMAS · 2021 to 2023
$123k
NIMH NIH HHS F31 MH124282NIMH NIH HHS R01 MH129292NINDS NIH HHS P30 NS050274
6 · The paper itself

Abstract

Abnormal neuronal and synapse growth is a core pathology resulting from deficiency of the Fragile X mental retardation protein (FMRP), but molecular links underlying the excessive synthesis of key synaptic proteins remain incompletely defined. We find that basal brain levels of the growth suppressor let-7 microRNA (miRNA) family are selectively lowered in FMRP-deficient mice and activity-dependent let-7 downregulation is abrogated. Primary let-7 miRNA transcripts are not altered in FMRP-deficiency and posttranscriptional misregulation occurs downstream of MAPK pathway induction and elevation of Lin28a, a let-7 biogenesis inhibitor. Neonatal restoration of brain let-7 miRNAs corrects hallmarks of FMRP-deficiency, including dendritic spine overgrowth and social and cognitive behavioral deficits, in adult mice. Blockade of MAPK hyperactivation normalizes let-7 miRNA levels in both brain and peripheral blood plasma from

Indexed as

Behavioral neuroscienceMolecular neuroscience

Identifiers

PMID38235335
PMCPMC10792201
OpenAlexW4389619496

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.