Evidence map›Paper›PMID 38235065›Full record

ArticleArXiv2023

Scale invariance in early embryonic development.

Miloš Nikolić, Victoria Antonetti, Feng Liu, Gentian Muhaxheri, Mariela D Petkova, Martin Scheeler, Eric M Smith, William Bialek, Thomas Gregor

Abstract readPreprint
PubMed Full text at PMC
In one paragraph

Article in ArXiv, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Miloš NikolićJoseph Henry Laboratories of Physics and Princeton University, Princeton NJ 08544 USA.
Victoria AntonettiJoseph Henry Laboratories of Physics and Princeton University, Princeton NJ 08544 USA.
Feng LiuLewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton NJ 08544 USA.
Gentian MuhaxheriJoseph Henry Laboratories of Physics and Princeton University, Princeton NJ 08544 USA.
Mariela D PetkovaProgram in Biophysics, Harvard University, Cambridge MA 02138 USA.
Martin ScheelerJoseph Henry Laboratories of Physics and Princeton University, Princeton NJ 08544 USA.
Eric M SmithJoseph Henry Laboratories of Physics and Princeton University, Princeton NJ 08544 USA.
William BialekJoseph Henry Laboratories of Physics and Princeton University, Princeton NJ 08544 USA.
Thomas GregorJoseph Henry Laboratories of Physics and Princeton University, Princeton NJ 08544 USA.

Funding

The Biophysical and Molecular Mechanisms of Reliability in DevelopmentR01GM097275 · NIGMS · PRINCETON UNIVERSITY · PI GREGOR, THOMAS · 2011 to 2024
$4.9M
Dynamics, scaling, and precision of morphogen gradients in the Drosophila embryoR01GM077599 · NIGMS · PRINCETON UNIVERSITY · PI BIALEK, WILLIAM · 2006 to 2009
$1.2M
NIGMS NIH HHS R01 GM077599NIGMS NIH HHS R01 GM097275
6 · The paper itself

Abstract

The body plan of the fruit fly is determined by the expression of just a handful of genes. We show that the spatial patterns of expression for several of these genes scale precisely with the size of the embryo. Concretely, discrete positional markers such as the peaks in striped patterns have absolute positions along the anterior-posterior axis that are proportional to embryo length, with better than 1% accuracy. Further, the information (in bits) that graded patterns of expression provide about position can be decomposed into information about fractional or scaled position and information about absolute position or embryo length; all of the available information is about scaled position, again with ~ 1% accuracy. These observations suggest that the underlying genetic network exhibits scale invariance in a deeper mathematical sense. Taking this mathematical statement seriously requires that the network dynamics have a zero mode, which connects to many other observations on this system.

Identifiers

PMID38235065
PMCPMC10793483

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.