Evidence map›Paper›PMID 38235060›Full record

ArticleThe journal of cardiovascular aging2023

GDF11 and aging biology - controversies resolved and pending.

Laura Ben Driss, John Lian, Ryan G Walker, James A Howard, Thomas B Thompson, Lee L Rubin, Amy J Wagers, Richard T Lee

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The journal of cardiovascular aging, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. [Growth differentiation factor 11 attenuates hypoxia/reoxygenation injury in rat H9C2 cardiomyocytesNan fang yi ke da xue xue bao = Journal of Southern Medical University · 2026
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Laura Ben DrissDepartment of Stem Cell and Regenerative Biology and the Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA.
John LianDepartment of Stem Cell and Regenerative Biology and the Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA.
Ryan G WalkerDepartment of Stem Cell and Regenerative Biology and the Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA.
James A HowardDepartment of Pharmacology and Systems Physiology, University of Cincinnati, Cincinnati, OH 45267, USA.
Thomas B ThompsonDepartment of Molecular and Cellular Biosciences, University of Cincinnati, Cincinnati, OH 45267, USA.
Lee L RubinDepartment of Stem Cell and Regenerative Biology and the Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA.
Amy J WagersDepartment of Stem Cell and Regenerative Biology and the Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA.
Richard T LeeDepartment of Stem Cell and Regenerative Biology and the Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA.
Harvard University · USUniversity of Cincinnati · USHarvard Stem Cell Institute · US

Funding

Direct and Indirect Effects of GDF11 in the Aging Central Nervous SystemR01AG072086 · NIA · HARVARD UNIVERSITY · PI RUBIN, LEE L · 2020 to 2024
$3.1M
Regulation of GDF11 by extracellular mechanismsR01AG072087 · NIA · UNIVERSITY OF CINCINNATI · PI THOMPSON, THOMAS B · 2020 to 2024
$2.8M
Structural/functional characterization of TGFβ superfamily signaling and regulationR35GM134923 · NIGMS · UNIVERSITY OF CINCINNATI · PI THOMPSON, THOMAS B · 2020 to 2024
$2.6M
Myocardial Physiology of Growth Differentiation Factor SignalingR01HL169291 · NHLBI · HARVARD UNIVERSITY · PI RICHARD T LEE · 2023 to 2026
$2.4M
Investigating GDF11 and MSTN as candidate circulating geronic factorsR01AG057428 · NIA · HARVARD UNIVERSITY · PI WAGERS, AMY JO · 2017 to 2020
$2.0M
NHLBI NIH HHS R01 HL169291NIA NIH HHS R01 AG057428NIA NIH HHS R01 AG072086NIA NIH HHS R01 AG072087NIGMS NIH HHS R35 GM134923
6 · The paper itself

Abstract

Since the exogenous administration of GDF11, a TGF-ß superfamily member, was reported to have beneficial effects in some models of human disease, there have been many research studies in GDF11 biology. However, many studies have now confirmed that exogenous administration of GDF11 can improve physiology in disease models, including cardiac fibrosis, experimental stroke, and disordered metabolism. GDF11 is similar to GDF8 (also called Myostatin), differing only by 11 amino acids in their mature signaling domains. These two proteins are now known to be biochemically different both

Indexed as

agingbrainGDF11heartskeletal musclesystemic factor

Identifiers

PMID38235060
PMCPMC10793994
OpenAlexW4387741808

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.