Evidence map›Paper›PMID 38234913›Full record

ArticleHeliyon2024

Tackling the implementation gap for the uptake of NGS and advanced molecular diagnostics into healthcare systems.

Denis Horgan, Marc Van den Bulcke, Umberto Malapelle, Giancarlo Troncone, Nicola Normanno, Ettore D Capoluongo, Arsela Prelaj, Carmelo Rizzari, Dario Trapani, Jaya Singh and 12 more

Abstract read
In one paragraph

Article in Heliyon, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Liquid biopsy in solid tumours: expert opinion paper of the European society of pathology.Virchows Archiv : an international journal of pathology · 2026
    Review
  2. Long-read sequencing for neurological disorders: opportunities, challenges, and future directions.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
    Review
  3. Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. Review
  15. Review
  16. Review
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Denis HorganEuropean Alliance for Personalised Medicine, Brussels, Belgium.
Marc Van den BulckeBelgian Cancer Centre, Sciensano, Brussels, Belgium.
Umberto MalapelleDepartment of Public Health, University Federico II of Naples, 80131 Naples, Italy.
Giancarlo TronconeDepartment of Public Health, University Federico II of Naples, 80131 Naples, Italy.
Nicola NormannoIstituto Nazionale Tumori "Fondazione G. Pascale" - IRCCS, Naples, Italy.
Ettore D CapoluongoDepartment of Molecular Medicine and Medical Biotechnologies, University of Naples Federico II, Naples, Italy.
Arsela PrelajDepartment of Medical Oncology, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy.
Carmelo RizzariUnità di Ematologia Pediatrica, Fondazione MBBM, Università di Milano-Bicocca, Monza, Italy.
Dario TrapaniEuropean Institute of Oncology, IRCCS, 20141 Milan, Italy.
Jaya SinghEuropean Alliance for Personalised Medicine, Brussels, Belgium.
Marta KozaricEuropean Alliance for Personalised Medicine, Brussels, Belgium.
John LongshoreAstra Zeneca, 1800 Concord Pike, Wilmington, DE 19803, USA.
Manuel OttavianoDepartamento de Tecnología Fotónica y Bioingeniería, Universidad Politècnica de Madrid, 28040 Madrid, Spain.
Stefania BocciaSection of Hygiene, Department of Life Sciences and Public Health, Università Cattolica del Sacro Cuore, Rome, Italy.
Gabriella PravettoniDepartment of Oncology and Hemato-Oncology, University of Milan, Milan, Italy.
Ivana CattaneoNovartis Farma SpA, 21040 Origgio, Italy.
Núria MalatsGenetic and Molecular Epidemiology Group, Spanish National Cancer Research Centre (CNIO), Madrid 28029, Spain.
Reinhard BuettnerLung Cancer Group Cologne, Institute of Pathology, Center for Integrated Oncology Cologne/Bonn, University Hospital Cologne, Cologne, Germany.
Karim LekadirArtificial Intelligence in Medicine Lab (BCN-AIM), Universitat de Barcelona, Barcelona, Spain.
Francesco de LorenzoEuropean Cancer Patient Coalition, Brussels, Belgium.
Paul HofmanLaboratory of Clinical and Experimental Pathology, Pasteur Hospital, Université Côte d'Azur, 06000 Nice, France.
Ruggero De MariaInstitute of General Pathology, Catholic University of the Sacred Heart, Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Next-generation sequencing (NGS) and liquid biopsy (LB) showed positive results in the fight against different cancer types. This paper aims to assess the uptake of advanced molecular diagnostics/NGS for quick and efficient genetic profiles of tumour cells. For that purpose, the European Alliance for Personalised Medicine conducted a series of expert interviews to ascertain the current status across member states. One stakeholder meeting was additionally conducted to prioritize relevant factors by stakeholders. Seven common pillars were identified, and twenty-five measures were defined based on these pillars. Results showed that a multi-faceted approach is necessary for successful NGS implementation and that regional differences may be influenced by healthcare policies, resources, and infrastructure. It is important to consider different correlations when interpreting the results and to use them as a starting point for further discussion.

Indexed as

InfrastructureMolecular diagnosticsNext-generation sequencingPersonalised medicinePolicyReimbursement

Identifiers

PMID38234913
PMCPMC10792189

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.