Evidence map›Paper›PMID 38234838›Full record

ArticlebioRxiv : the preprint server for biology2025

Immune-responsive gene-1: The mitochondrial Key to Th17 Cell Pathogenicity in CNS Autoimmunity.

Mohammad Nematullah, Mena Fatma, Guoli Zhou, Faraz Rashid, Kameshwar Ayasolla, Mohammad Ejaz Ahmed, Ruicong She, Sajad Mir, Insha Zahoor, Nasrul Hoda and 2 more

Open access · greenAbstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Mohammad NematullahDepartment of Neurology, Henry Ford Health System, Detroit, MI, 48202, USA.
Mena FatmaDepartment of Neurology, Henry Ford Health System, Detroit, MI, 48202, USA.
Guoli ZhouCenter for Statistical Training & Consulting (CSTAT), Michigan State University, 293 Farm Lane, East Lansing, MI.
Faraz RashidDepartment of Neurology, Henry Ford Health System, Detroit, MI, 48202, USA.
Kameshwar AyasollaDepartment of Neurology, Henry Ford Health System, Detroit, MI, 48202, USA.
Mohammad Ejaz AhmedDepartment of Neurology, Henry Ford Health System, Detroit, MI, 48202, USA.
Ruicong SheDepartment of Public Health Sciences, Henry Ford Health System, Detroit, MI, 48202, USA.
Sajad MirDepartment of Neurology, Henry Ford Health System, Detroit, MI, 48202, USA.
Insha ZahoorDepartment of Neurology, Henry Ford Health System, Detroit, MI, 48202, USA.ORCID 0000-0001-9919-1959
Nasrul HodaDepartment of Neurology, Henry Ford Health System, Detroit, MI, 48202, USA.
Ramandeep RattanDivision of Gynecology Oncology, Department of Women's Health Services, Henry Ford Hospital, Detroit, MI, 48202, USA.
Shailendra GiriDepartment of Neurology, Henry Ford Health System, Detroit, MI, 48202, USA.ORCID 0000-0002-7123-829X
Henry Ford Health System · USHenry Ford Hospital · US

Funding

Novel Regulation and Targeting of Macrophages Metabolism in Neuroinflammatory DisordersR01AI144004 · NIAID · HENRY FORD HEALTH SYSTEM · PI GIRI, SHAILENDRA · 2019 to 2023
$1.9M
Endogenous metabolite restricts GM-CSF signaling pathway in pathogenic macrophages to ameliorate CNS AutoimmunityR01NS112727 · NINDS · HENRY FORD HEALTH SYSTEM · PI GIRI, SHAILENDRA · 2019 to 2023
$1.6M
NIAID NIH HHS R01 AI144004NINDS NIH HHS R01 NS112727
6 · The paper itself

Abstract

Pathogenic Th17 cells play crucial roles in CNS autoimmune diseases such as multiple sclerosis (MS), but their regulation by endogenous mechanisms remains unknown. Through RNA-seq analysis of primary brain glial cells, we identified immuno-responsive gene 1 (

Indexed as

EAEGM-CSFIFNγIL17aIL1βIrg1macrophageMultiple sclerosisTh17

Identifiers

PMID38234838
PMCPMC10793427
OpenAlexW4390191236

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.