Evidence map›Paper›PMID 38234832›Full record

ArticlebioRxiv : the preprint server for biology2025

Protosequences in brain organoids model intrinsic brain states Authors.

Tjitse van der Molen, Alex Spaeth, Mattia Chini, Sebastian Hernandez, Gregory A Kaurala, Hunter E Schweiger, Cole Duncan, Sawyer McKenna, Jinghui Geng, Max Lim and 21 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 10 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

31 authors at 6 institutions in 3 countries.

Tjitse van der MolenNeuroscience Research Institute, University of California Santa Barbara, Santa Barbara, CA 93106, USA.ORCID 0000-0001-6147-542X
Alex SpaethUC Santa Cruz Genomics Institute, University of California Santa Cruz, Santa Cruz, CA 95060, USA.ORCID 0000-0003-0702-3945
Mattia ChiniInstitute of Developmental Neurophysiology, Center for Molecular Neurobiology, Hamburg Center of Neuroscience, University Medical Center Hamburg-Eppendorf, 20251 Hamburg, Germany.ORCID 0000-0002-5782-9720
Sebastian HernandezUC Santa Cruz Genomics Institute, University of California Santa Cruz, Santa Cruz, CA 95060, USA.ORCID 0009-0000-8811-8596
Gregory A KauralaUC Santa Cruz Genomics Institute, University of California Santa Cruz, Santa Cruz, CA 95060, USA.
Hunter E SchweigerUC Santa Cruz Genomics Institute, University of California Santa Cruz, Santa Cruz, CA 95060, USA.ORCID 0000-0003-0399-9481
Cole DuncanUC Santa Cruz Genomics Institute, University of California Santa Cruz, Santa Cruz, CA 95060, USA.
Sawyer McKennaDepartment of Biomolecular Engineering, University of California Santa Cruz, Santa Cruz, CA 95064, USA.
Jinghui GengUC Santa Cruz Genomics Institute, University of California Santa Cruz, Santa Cruz, CA 95060, USA.ORCID 0000-0002-3431-9568
Max LimNeuroscience Research Institute, University of California Santa Barbara, Santa Barbara, CA 93106, USA.ORCID 0009-0003-1403-7875
Julian BartramDepartment of Biosystems Science and Engineering, ETH Zürich, Klingelbergstrasse 48, 4056 Basel, Switzerland.ORCID 0000-0001-7513-1716
Aditya DendukuriDepartment of Computer Science, University of California Santa Barbara, Santa Barbara, CA 93106, USA.ORCID 0000-0001-7350-868X
Zongren ZhangDepartment of Physics, University of California Santa Barbara, Santa Barbara, CA 93106.ORCID 0009-0001-7709-9980
Jesus Gonzalez-FerrerUC Santa Cruz Genomics Institute, University of California Santa Cruz, Santa Cruz, CA 95060, USA.ORCID 0000-0002-5588-921X
Kiran Bhaskaran-NairDepartment of Biology, Washington University in St. Louis, St. Louis, MO 63130, USA.ORCID 0000-0001-6855-8244
Lon J BlauveltUC Santa Cruz Genomics Institute, University of California Santa Cruz, Santa Cruz, CA 95060, USA.ORCID 0000-0001-8352-873X
Cole R K HarderDepartment of Molecular, Cell and Developmental Biology, University of California, Santa Cruz, CA 95064, USA.
Linda R PetzoldDepartment of Computer Science, University of California Santa Barbara, Santa Barbara, CA 93106, USA.ORCID 0000-0001-6251-6078
Dowlette-Mary Alam El DinCenter for Alternatives to Animal Testing (CAAT), Department of Environmental Health and Engineering, Bloomberg School of Public Health Johns Hopkins University, Baltimore, MD 21205, USA.ORCID 0000-0002-3886-2082
Jason LairdCenter for Alternatives to Animal Testing (CAAT), Department of Environmental Health and Engineering, Bloomberg School of Public Health Johns Hopkins University, Baltimore, MD 21205, USA.
Maren SchenkeCenter for Alternatives to Animal Testing (CAAT), Department of Environmental Health and Engineering, Bloomberg School of Public Health Johns Hopkins University, Baltimore, MD 21205, USA.
Lena SmirnovaCenter for Alternatives to Animal Testing (CAAT), Department of Environmental Health and Engineering, Bloomberg School of Public Health Johns Hopkins University, Baltimore, MD 21205, USA.ORCID 0000-0003-0171-3881
Bradley M ColquittUC Santa Cruz Genomics Institute, University of California Santa Cruz, Santa Cruz, CA 95060, USA.ORCID 0000-0001-5819-7924
Mohammed A Mostajo-RadjiUC Santa Cruz Genomics Institute, University of California Santa Cruz, Santa Cruz, CA 95060, USA.ORCID 0000-0002-1634-7514
Paul K HansmaNeuroscience Research Institute, University of California Santa Barbara, Santa Barbara, CA 93106, USA.ORCID 0000-0002-0719-0615
Mircea TeodorescuUC Santa Cruz Genomics Institute, University of California Santa Cruz, Santa Cruz, CA 95060, USA.ORCID 0000-0001-7085-5248
Andreas HierlemannDepartment of Biosystems Science and Engineering, ETH Zürich, Klingelbergstrasse 48, 4056 Basel, Switzerland.ORCID 0000-0002-3838-2468
Keith B HengenDepartment of Biology, Washington University in St. Louis, St. Louis, MO 63130, USA.ORCID 0000-0001-5017-4090
Ileana L Hanganu-OpatzInstitute of Developmental Neurophysiology, Center for Molecular Neurobiology, Hamburg Center of Neuroscience, University Medical Center Hamburg-Eppendorf, 20251 Hamburg, Germany.ORCID 0000-0002-4787-1765
Kenneth S KosikNeuroscience Research Institute, University of California Santa Barbara, Santa Barbara, CA 93106, USA.ORCID 0000-0003-3224-5179
Tal SharfUC Santa Cruz Genomics Institute, University of California Santa Cruz, Santa Cruz, CA 95060, USA.ORCID 0000-0002-7899-2818
University of California, Santa Cruz · USUniversity of California, Santa Barbara · USJohns Hopkins University · USETH Zurich · CHUniversität Hamburg · DEWashington University in St. Louis · US

Funding

Traning Program in Environmental Health SciencesT32ES007141 · NIEHS · JOHNS HOPKINS UNIVERSITY · PI Marsha Wills-Karp · 1985 to 2026
$22.2M
Nanoparticle Tracking Analyzer (NTA) for the Center for Live Cell GenomicsRM1HG011543 · NHGRI · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI HAUSSLER, DAVID H, SALAMA, SOFIE REDA · 2021 to 2025
$12.0M
Robust circuit computation in freely behaving animals.R01NS118442 · NINDS · WASHINGTON UNIVERSITY · PI HENGEN, KEITH B. · 2023 to 2024
$1.0M
NHGRI NIH HHS RM1 HG011543NIEHS NIH HHS T32 ES007141NINDS NIH HHS R01 NS118442
6 · The paper itself

Abstract

Neuronal firing sequences are thought to be the basic building blocks of neural coding and information broadcasting within the brain. However, when sequences emerge during neurodevelopment remains unknown. We demonstrate that structured firing sequences are present in spontaneous activity of human and murine brain organoids and

Identifiers

PMID38234832
PMCPMC10793448
OpenAlexW4390443537

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.