Evidence map›Paper›PMID 38234831›Full record

ArticlebioRxiv : the preprint server for biology2023

A targeted CRISPR-Cas9 mediated F0 screen identifies genes involved in establishment of the enteric nervous system.

Rodrigo Moreno-Campos, Eileen W Singleton, Rosa A Uribe

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Rodrigo Moreno-CamposBiosciences Department, Rice University, Houston, Texas, 77005, U.S.A.
Eileen W SingletonBiosciences Department, Rice University, Houston, Texas, 77005, U.S.A.
Rosa A UribeBiosciences Department, Rice University, Houston, Texas, 77005, U.S.A.
Rice University · US

Funding

Genetic and extrinsic mechanisms governing early enteric nervous system developmentR01DK124804 · NIDDK · RICE UNIVERSITY · PI URIBE, ROSA A · 2021 to 2025
$1.9M
NIDDK NIH HHS R01 DK124804
6 · The paper itself

Abstract

The vertebrate enteric nervous system (ENS) is a crucial network of enteric neurons and glia resident within the entire gastrointestinal tract (GI). Overseeing essential GI functions such as gut motility and water balance, the ENS serves as a pivotal bidirectional link in the gut-brain axis. During early development, the ENS is primarily derived from enteric neural crest cells (ENCCs). Disruptions to ENCC development, as seen in conditions like Hirschsprung disease (HSCR), lead to absence of ENS in the GI, particularly in the colon. In this study, using zebrafish, we devised an

Indexed as

CRISPR screenenteric nervous systementeric nervous system developmententeric neuronopioidzebrafish

Identifiers

PMID38234831
PMCPMC10793464
OpenAlexW4390403497

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.