Evidence map›Paper›PMID 38234830›Full record

ArticlebioRxiv : the preprint server for biology2023

Exposure and resistance to lantibiotics impact microbiota composition and function.

Zhenrun J Zhang, Cody Cole, Huaiying Lin, Chunyu Wu, Fidel Haro, Emma McSpadden, Wilfred A van der Donk, Eric G Pamer

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 4 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Zhenrun J ZhangDuchossois Family Institute, University of Chicago, 900 E. 57th St, Chicago, IL 60637, USA; Department of Microbiology, Biological Sciences Division, University of Chicago, 5841 South Maryland Ave, Chicago, IL 60637, USA.ORCID 0000-0002-2124-5539
Cody ColeDuchossois Family Institute, University of Chicago, 900 E. 57th St, Chicago, IL 60637, USA; Department of Microbiology, Biological Sciences Division, University of Chicago, 5841 South Maryland Ave, Chicago, IL 60637, USA.
Huaiying LinDuchossois Family Institute, University of Chicago, 900 E. 57th St, Chicago, IL 60637, USA.
Chunyu WuDepartment of Chemistry, University of Illinois Urbana-Champaign, IL 61801, USA.
Fidel HaroDuchossois Family Institute, University of Chicago, 900 E. 57th St, Chicago, IL 60637, USA.
Emma McSpaddenDuchossois Family Institute, University of Chicago, 900 E. 57th St, Chicago, IL 60637, USA.
Wilfred A van der DonkDepartment of Chemistry, University of Illinois Urbana-Champaign, IL 61801, USA; Howard Hughes Medical Institute, University of Illinois Urbana-Champaign, IL 61801, USA.
Eric G PamerDuchossois Family Institute, University of Chicago, 900 E. 57th St, Chicago, IL 60637, USA; Department of Medicine, Section of Infectious Diseases & Global Health, University of Chicago Medicine, 5841 South Maryland Ave, Chicago, IL 60637, USA; Department of Microbiology, Biological Sciences Division, University of Chicago, 5841 South Maryland Ave, Chicago, IL 60637, USA.
University of Chicago · USHoward Hughes Medical Institute · USUniversity of Illinois Urbana-Champaign · US

Funding

T LYMPHOCYTE SUBSET FUNCTION POST-TRANSPLANTATIONP01CA023766 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SCHEINBERG, DAVID A · 1985 to 2023
$59.0M
Systems Biology of Microbiome-mediated Resilience to Antibiotic-resistant PathogensU01AI124275 · NIAID · SLOAN-KETTERING INST CAN RESEARCH · PI PAMER, ERIC G., XAVIER, JOAO · 2016 to 2020
$8.9M
TNF Mediated Immune Defense Against Listeria InfectionR01AI042135 · NIAID · YALE UNIVERSITY · PI PAMER, ERIC G. · 1998 to 2019
$7.3M
Innate Immune Defense against Clostridium Difficile InfectionR01AI095706 · NIAID · UNIVERSITY OF CHICAGO · PI PAMER, ERIC G. · 2012 to 2020
$3.4M
NCI NIH HHS P01 CA023766NIAID NIH HHS R01 AI042135NIAID NIH HHS R01 AI095706NIAID NIH HHS U01 AI124275
6 · The paper itself

Abstract

The intestinal microbiota is composed of hundreds of distinct microbial species that interact with each other and their mammalian host. Antibiotic exposure dramatically impacts microbiota compositions and leads to acquisition of antibiotic-resistance genes. Lantibiotics are ribosomally synthesized and post-translationally modified peptides produced by some bacterial strains to inhibit the growth of competing bacteria. Nisin A is a lantibiotic produced by

Identifiers

PMID38234830
PMCPMC10793476
OpenAlexW4390469867

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.