Evidence map›Paper›PMID 38234819›Full record

ArticlebioRxiv : the preprint server for biology2023

PNLDC1 catalysis and postnatal germline function are required for piRNA trimming, LINE1 silencing, and spermatogenesis in mice.

Chao Wei, Xiaoyuan Yan, Jeffrey M Mann, Ruirong Geng, Huirong Xie, Elena Y Demireva, Liangliang Sun, Deqiang Ding, Chen Chen

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Chao WeiDepartment of Animal Science, Michigan State University, East Lansing, Michigan 48824, USA.
Xiaoyuan YanDepartment of Animal Science, Michigan State University, East Lansing, Michigan 48824, USA.
Jeffrey M MannDepartment of Animal Science, Michigan State University, East Lansing, Michigan 48824, USA.
Ruirong GengShanghai Key Laboratory of Maternal and Fetal Medicine, Clinical and Translational Research Center, Shanghai First Maternity and Infant Hospital, Frontier Science Center for Stem Cell Research, School of Life Sciences and Technology, Tongji University, Shanghai 200092, China.
Huirong XieTransgenic and Genome Editing Facility, Institute for Quantitative Health Science & Engineering, Michigan State University, East Lansing, Michigan 48824, USA.
Elena Y DemirevaTransgenic and Genome Editing Facility, Institute for Quantitative Health Science & Engineering, Michigan State University, East Lansing, Michigan 48824, USA.
Liangliang SunDepartment of Chemistry, Michigan State University, East Lansing, Michigan 48824, USA.
Deqiang DingShanghai Key Laboratory of Maternal and Fetal Medicine, Clinical and Translational Research Center, Shanghai First Maternity and Infant Hospital, Frontier Science Center for Stem Cell Research, School of Life Sciences and Technology, Tongji University, Shanghai 200092, China.
Chen ChenDepartment of Animal Science, Michigan State University, East Lansing, Michigan 48824, USA.ORCID 0000-0001-9159-4489
Michigan State University · USShanghai First Maternity and Infant Hospital · CN

Funding

Tudor Domain Proteins in Germline Genome DefenseR01HD084494 · NICHD · MICHIGAN STATE UNIVERSITY · PI CHEN, CHEN · 2015 to 2023
$3.0M
Mitochondria-anchored protein complexes in piRNA biogenesis and functionR01GM132490 · NIGMS · MICHIGAN STATE UNIVERSITY · PI CHEN, CHEN · 2019 to 2022
$1.2M
NICHD NIH HHS R01 HD084494NIGMS NIH HHS R01 GM132490
6 · The paper itself

Abstract

PIWI-interacting RNAs (piRNAs) play critical and conserved roles in transposon silencing and gene regulation in the animal germline. Two distinct piRNA populations are present during mouse spermatogenesis: pre-pachytene piRNAs in fetal/neonatal testes and pachytene piRNAs in adult testes. PNLDC1 is required for both pre-pachytene piRNA and pachytene piRNA 3' end maturation in multiple species. However, whether PNLDC1 is the bona fide piRNA trimmer and the physiological role of 3' trimming of two distinct piRNA populations in spermatogenesis remain unclear. Here, by inactivating

Identifiers

PMID38234819
PMCPMC10793440
OpenAlexW4390297970

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.