Evidence map›Paper›PMID 38234776›Full record

ArticlemedRxiv : the preprint server for health sciences2023

Maternal SARS-CoV-2 impacts fetal placental macrophage programs and placenta-derived microglial models of neurodevelopment.

Lydia L Shook, Rebecca A Batorsky, Rose M De Guzman, Liam T McCrea, Sara M Brigida, Joy E Horng, Steven D Sheridan, Olha Kholod, Aidan M Cook, Jonathan Z Li and 3 more

Open access · greenAbstract readPreprint
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Accuracy of ChatGPT in head and neck oncological board decisions: preliminary findings.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2024
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 1 country.

Rebecca A BatorskyORCID 0000-0003-4712-6500
Steven D SheridanORCID 0000-0003-1045-1158
Aidan M Cook
Jonathan Z Li
Brittany A Goods
Harvard University · USDartmouth College · USBrigham and Women's Hospital · USMassachusetts General Hospital · USTufts University · US

Funding

Research Project 2 The pregnancy AdaptOMEU19AI167899 · NIAID · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI DOUGLAS A LAUFFENBURGER · 2022 to 2026
$14.7M
Cellular models of fetal neurodevelopment in maternal SARS-CoV-2 infectionRF1MH132336 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI EDLOW, ANDREA GOLDBERG, PERLIS, ROY H. · 2022 to 2022
$2.6M
Sex Differences in Fetal Brain-Placental Immune Programming in Maternal ObesityR01HD100022 · NICHD · MASSACHUSETTS GENERAL HOSPITAL · PI EDLOW, ANDREA GOLDBERG · 2019 to 2021
$2.0M
Transdisciplinary Harvard WRHR Career Development for Gynecologists and ObstetriciansK12HD103096 · NICHD · BRIGHAM AND WOMEN'S HOSPITAL · PI NOUR, NAWAL M. · 2020 to 2024
$1.5M
NIAID NIH HHS U19 AI167899NICHD NIH HHS R01 HD100022
6 · The paper itself

Abstract

The SARS-CoV-2 virus activates maternal and placental immune responses, which in the setting of other infections occurring during pregnancy are known to impact fetal brain development. The effects of maternal immune activation on neurodevelopment are mediated at least in part by fetal brain microglia. However, microglia are inaccessible for direct analysis, and there are no validated non-invasive surrogate models to evaluate

Identifiers

PMID38234776
PMCPMC10793528
OpenAlexW4390444236

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.