Evidence map›Paper›PMID 38234772›Full record

ArticlemedRxiv : the preprint server for health sciences2023

Projected Impact of Nonpharmacologic Management of Stage 1 Hypertension Among Lower-Risk US Adults.

Kendra D Sims, Pengxiao Carol Wei, Joanne M Penko, Susan Hennessy, Pamela G Coxson, Nita H Mukand, Brandon K Bellows, Dhruv S Kazi, Yiyi Zhang, Ross Boylan and 2 more

Open access · greenAbstract readPreprint
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Kendra D SimsDepartment of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California.ORCID 0000-0002-6740-3002
Pengxiao Carol WeiDepartment of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California.
Joanne M PenkoDepartment of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California.
Susan HennessyDepartment of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California.
Pamela G CoxsonDepartment of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California.
Nita H MukandDepartment of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California.
Brandon K BellowsDepartment of Medicine, Division of General Medicine, Columbia University Irving Medical Center, New York, New York.ORCID 0000-0003-1395-6047
Dhruv S KaziRichard A. and Susan F. Smith Center for Outcomes Research in Cardiology, Division of Cardiology, Beth Israel Deaconess Medical Center, and Harvard Medical School, Boston, Massachusetts.ORCID 0000-0002-9510-2979
Yiyi ZhangDepartment of Medicine, Division of General Medicine, Columbia University Irving Medical Center, New York, New York.ORCID 0000-0002-8663-5001
Ross BoylanDepartment of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California.
Andrew E MoranDepartment of Medicine, Division of General Medicine, Columbia University Irving Medical Center, New York, New York.ORCID 0000-0003-3554-0085
Kirsten Bibbins-DomingoDepartment of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California.
University of California, San Francisco · USColumbia University · USBeth Israel Deaconess Medical Center · USSan Francisco General Hospital · US

Funding

Community Empowerment, Vascular Risk, and ADRD Disparities: Translating Research to Public PolicyK99AG083121 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI SIMS, KENDRA D · 2023 to 2024
$243k
NIA NIH HHS K99 AG083121
6 · The paper itself

Abstract

Background: The 2017 American College of Cardiology (ACC)/American Heart Association (AHA) guidelines newly classified 31 million US adults as having stage 1 hypertension. The ACC/AHA guidelines recommend behavioral change without pharmacology for the low-risk portion of this group. However, the nationwide reduction in cardiovascular disease (CVD) and associated healthcare expenditures achievable by evidence-based dietary improvements, sustained weight loss, adequate physical activity, and alcohol moderation remain unquantified. We estimated the effect of systolic BP (SBP) control and behavioral changes on 10-year CVD outcomes and costs. Methods: We used the CVD Policy Model to simulate CVD events, mortality, and healthcare costs among US adults aged 35-64. We simulated interventions on a target population, identified from the 2015-2018 National Health and Nutrition Examination Survey, with low-risk stage 1 systolic hypertension Results: Controlling SBP to <130 mmHg among the estimated 8.8 million U.S. adults (51% women) in the target population could prevent 26,100 CVD events, avoid 2,900 deaths, and save $1.6 billion in healthcare costs over 10 years. The Dietary Approaches to Stop Hypertension (DASH) diet could prevent 16,000 CVD events among men and 12,000 among women over a decade. Other nonpharmacologic interventions could avert between 3,700 and 19,500 CVD events. However, only 5.5 million (61%) of the target population regularly utilized healthcare where recommended clinician counseling could occur. Conclusions: As only two-thirds of U.S. adults with Stage 1 hypertension regularly receive medical care, substantial benefits to cardiovascular health and associated costs may only stem from policies that promote widespread adoption and sustained adherence of nonpharmacologic therapy. Future work should quantify the population-level costs, benefits, and efficacy of improving the food system and local infrastructure on health behavior change.

Indexed as

behavioral interventioncardiovascular diseaseclinical guidelineshypertensionpublic policy

Identifiers

PMID38234772
PMCPMC10793531
OpenAlexW4390393594

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.