ArticleResearch square2023
Enrichment of a neutrophil-like monocyte transcriptional state in glioblastoma myeloid suppressor cells.
J K Wiencke, Emily Nissen, Devin C Koestler, Stan J Tamaki, Courtney M Tamaki, Helen M Hansen, Gayathri Warrier, Sara Hadad, Lucie McCoy, Terri Rice and 7 more
Open access · greenAbstract readPreprint
In one paragraphArticle in Research square, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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0citing papers in PubMed
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What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed, 3 citations in OpenAlex.
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4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
17 authors at 4 institutions in 2 countries.
J K WienckeDepartment of Neurological Surgery, University of California San Francisco, San Francisco, CA.ORCID 0000-0001-7101-6489 Emily NissenDepartment of Biostatistics & Data Science, University of Kansas Medical Center, Kansas City, KS.ORCID 0000-0001-9020-336X Devin C KoestlerDepartment of Biostatistics & Data Science, University of Kansas Medical Center, Kansas City, KS.
Stan J TamakiParnassus Flow Cytometry CoLab, University of California San Francisco, San Francisco, CA 94143-0511, USA.
Courtney M TamakiParnassus Flow Cytometry CoLab, University of California San Francisco, San Francisco, CA 94143-0511, USA.
Helen M HansenDepartment of Neurological Surgery, University of California San Francisco, San Francisco, CA.ORCID 0000-0001-5456-4985 Gayathri WarrierDepartment of Neurological Surgery, University of California San Francisco, San Francisco, CA.ORCID 0000-0002-0716-8012 Sara HadadDepartment of Neurological Surgery, University of California San Francisco, San Francisco, CA.
Lucie McCoyDepartment of Neurological Surgery, University of California San Francisco, San Francisco, CA.ORCID 0000-0002-2728-6083 Terri RiceDepartment of Neurological Surgery, University of California San Francisco, San Francisco, CA.
Jennifer ClarkeDepartment of Neurological Surgery, University of California San Francisco, San Francisco, CA.ORCID 0000-0002-8054-7342 Jennie W TaylorDepartment of Neurological Surgery, University of California San Francisco, San Francisco, CA.ORCID 0000-0003-3980-5626 Brock C ChristensenDepartment of Epidemiology, Geisel School of Medicine, Dartmouth College, Lebanon, NH.
Rondi ButlerDepartment of Epidemiology, Brown University, Providence, RI.
Annette M MolinaroDepartment of Neurological Surgery, University of California San Francisco, San Francisco, CA.ORCID 0000-0002-9854-7404 University of California, San Francisco · USDartmouth College · USJohn Brown University · USUniversity of Kansas Medical Center · US
Funding
Mentoring CoreP20GM103418 · NIGMS · UNIVERSITY OF KANSAS MEDICAL CENTER · PI Douglas E Wright · 2012 to 2026
$63.0MTissue CoreP50CA097257 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Joseph F Costello · 2002 to 2026
$57.4MTransgenic & Gene-Targeting Shared ResourceP30CA168524 · NCI · UNIVERSITY OF KANSAS MEDICAL CENTER · PI ROY A. JENSEN · 2012 to 2026
$40.1MResearch BaseP30DK063720 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GERMAN, MICHAEL S · 2003 to 2019
$21.8MUsing Integrated Omics to Identify Dysfunctional Genetic Mechanisms Influencing Schizophrenia and Sleep DisturbancesP20GM130423 · NIGMS · UNIVERSITY OF KANSAS MEDICAL CENTER · PI Diane E Mahoney · 2019 to 2026
$21.5MTraining Program in Translational Brain Tumor ResearchT32CA151022 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Joseph F Costello · 2010 to 2026
$6.6MNCI NIH HHS P30 CA168524NCI NIH HHS P50 CA097257NCI NIH HHS T32 CA151022NIDDK NIH HHS P30 DK063720NIGMS NIH HHS P20 GM103418NIGMS NIH HHS P20 GM130423
6 · The paper itselfAbstract
Glioblastomas (GBM) are lethal central nervous system cancers associated with tumor and systemic immunosuppression. Heterogeneous monocyte myeloid-derived suppressor cells (M-MDSC) are implicated in the altered immune response in GBM, but M-MDSC ontogeny and definitive phenotypic markers are unknown. Using single-cell transcriptomics, we revealed heterogeneity in blood M-MDSC from GBM subjects and an enrichment in a transcriptional state reminiscent of neutrophil-like monocytes (NeuMo), a newly described pathway of monopoiesis in mice. Human NeuMo gene expression and Neu-like deconvolution fraction algorithms were created to quantitate the enrichment of this transcriptional state in GBM subjects. NeuMo populations were also observed in M-MDSCs from lung and head and neck cancer subjects. Dexamethasone (DEX) and prednisone exposures increased the usage of Neu-like states, which were inversely associated with tumor purity and survival in isocitrate dehydrogenase wildtype (IDH WT) gliomas. Anti-inflammatory
Identifiers
PMID38234734
PMCPMC10793488
OpenAlexW4390342933
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