ArticlemedRxiv : the preprint server for health sciences2023
Mapping inherited genetic variation with opposite effects on autoimmune disease and cancer identifies candidate drug targets associated with the anti-tumor immune response.
Article in medRxiv : the preprint server for health sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
4 authors at 2 institutions in 3 countries.
Funding
Abstract
Background: Germline alleles near genes that encode certain immune checkpoints ( Methods: Pairwise fixed effect cross-disorder meta-analyses combining genome-wide association studies (GWAS) for breast, prostate, ovarian and endometrial cancers (240,540 cases/317,000 controls) and seven autoimmune/autoinflammatory diseases (112,631 cases/895,386 controls) coupled with Results: Meta-analyses followed by linkage disequilibrium clumping identified 312 unique, independent lead variants with P Conclusion: We provide population-scale germline genetic and functional genomic evidence to support further evaluation of the proteins encoded by
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Registered trials
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