Evidence map›Paper›PMID 38234695›Full record

ArticleDose-response : a publication of International Hormesis Society

Ameliorative Potential of Pumpkin Seed Oil (

Ezebuilo U Ekpono, Ejike D Eze, Afodun M Adam, Udu A Ibiam, Orji U Obasi, Josiah E Ifie, Ejike U Ekpono, Esther U Alum, Sana Noreen, Chinaza G Awuchi and 1 more

Open access · goldAbstract read
In one paragraph

Article in Dose-response : a publication of International Hormesis Society. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
3.1field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Effects of Oral Pumpkin (Veterinary sciences · 2026
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 4 countries.

Ezebuilo U EkponoDepartment of Biochemistry, Ebonyi State University, Abakaliki, Nigeria.
Ejike D EzeDepartment of Physiology, School of Medicine, Kabale University, Kabale, Uganda.ORCID https://orcid.org/0000-0002-9119-8870
Afodun M AdamDepartment of Medical Imaging Science, School of Health Sciences, University of Rwanda, Rwanda.
Udu A IbiamDepartment of Biochemistry, Ebonyi State University, Abakaliki, Nigeria.
Orji U ObasiDepartment of Biochemistry, Ebonyi State University, Abakaliki, Nigeria.
Josiah E IfieDepartment of Biochemistry, Kampala International University, Bushenyi, Uganda.
Ejike U EkponoDepartment of Biochemistry, Ebonyi State University, Abakaliki, Nigeria.
Esther U AlumDepartment of Biochemistry, Ebonyi State University, Abakaliki, Nigeria.ORCID https://orcid.org/0000-0003-4105-8615
Sana NoreenUniversity Institute of Diet and Nutritional Sciences, University of Lahore, Lahore, Pakistan.
Chinaza G AwuchiDepartment of Biochemistry, Kampala International University, Bushenyi, Uganda.ORCID https://orcid.org/0000-0001-5071-8895
Patrick M AjaDepartment of Biochemistry, Ebonyi State University, Abakaliki, Nigeria.ORCID https://orcid.org/0000-0001-7805-9027
Kampala International University · UGEbonyi State University · NGFederal Polytechnic Oko · NGKabale University · UGUniversity of Lahore · PKUniversity of Rwanda · RW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background of the Study: The increase in the therapeutic use of tramadol in the management of moderate to severe pains in some disease conditions and its unregulated access has led to its associated toxicity and there is little or no information on the protection against its associated toxicity. Aim of the Study: Considering the medicinal value of pumpkin seed oil, its availability, and neglected use, it becomes necessary to evaluate the possible potential of the seed oil in tramadol-induced oxidative stress in Wister Albino rats. Methods of the Study: This study used fifty-six (56) albino rats to determine the impact of Results: TM toxicity was demonstrated by a considerable increase ( Conclusion: The dose-dependent delivery of CPSO was able to restore not only the activity but also the concentrations of the altered markers.

Indexed as

ameliorative potentialoxidative stresspumpkin seed oiltramadol

Identifiers

PMID38234695
PMCPMC10793191
OpenAlexW4390920290

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.