Evidence map›Paper›PMID 38234234›Full record

ArticleAnnals of clinical and translational neurology2024

The neural correlates of topographical disorientation-a lesion analysis study.

Eva Blondiaux, Andreas Diamantaras, Rahel Schumacher, Olaf Blanke, René Müri, Lukas Heydrich

Abstract read
In one paragraph

Article in Annals of clinical and translational neurology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Eva BlondiauxLaboratory of Cognitive Neuroscience, Brain-Mind Institute, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.
Andreas DiamantarasDepartment of Neurology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Rahel SchumacherDepartment of Neurology, Inselspital, University Neurorehabilitation, Bern University Hospital, University of Bern, Bern, Switzerland.
Olaf BlankeLaboratory of Cognitive Neuroscience, Brain-Mind Institute, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.
René MüriDepartment of Neurology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Lukas HeydrichDepartment of Neurology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.ORCID 0000-0001-8520-1300

Funding

Swiss National Science Foundation 140332Swiss National Science Foundation 140338Swiss National Science Foundation 146633Swiss National Science Foundation 33CM30-124089Swiss National Science Foundation 51AU40-125759
6 · The paper itself

Abstract

Topographical disorientation refers to the selective inability to orient oneself in familiar surroundings. However, to date its neural correlates remain poorly understood. Here we use quantitative lesion analysis and a lesion network mapping approach in order to investigate seven patients with topographical disorientation. Our findings link not only the posterior parahippocampal gyrus (PHG) and retrosplenial cortex but also the lingual gyrus, the precuneus and the fusiform gyrus to topographical disorientation. We propose that topographical disorientation is due to the inability to integrate familiar landmarks within a framework of allocentric and egocentric orientation, supported by a neural network including the posterior PHG, the retrosplenial and the lingual cortex.

Indexed as

Cerebral CortexConfusionGyrus CinguliHumansParietal LobeTemporal Lobe

Identifiers

PMID38234234
PMCPMC10863913

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.