Evidence map›Paper›PMID 38233865›Full record

ArticleJournal of neuroinflammation2024

Splenic monocytes drive pathogenic subretinal inflammation in age-related macular degeneration.

Christophe Roubeix, Caroline Nous, Sébastien Augustin, Kaitryn E Ronning, Thibaud Mathis, Frédéric Blond, Pauline Lagouge-Roussey, Sergio Crespo-Garcia, Patrick M Sullivan, Emmanuel L Gautier and 9 more

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neuroinflammation, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03418220 (Comparison of Cytokine Profiles in Aqueous Humor of Patients With Age Related Macular Degeneration), which is not on this map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03418220 nacompletednot on this map

Comparison of Cytokine Profiles in Aqueous Humor of Patients With Age Related Macular Degeneration (AMD)

TypeinterventionalSponsorHospices Civils de LyonRan2017 to 2020Enrolled82ConditionsMacular Degeneration, Age-RelatedArmsblood and aqueous humor sampling
3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 11 institutions in 4 countries.

Christophe RoubeixSorbonne Université, INSERM, CNRS, UMR_S 968, Institut de la Vision, 75012, Paris, France.
Caroline NousSorbonne Université, INSERM, CNRS, UMR_S 968, Institut de la Vision, 75012, Paris, France.
Sébastien AugustinSorbonne Université, INSERM, CNRS, UMR_S 968, Institut de la Vision, 75012, Paris, France.
Kaitryn E RonningSorbonne Université, INSERM, CNRS, UMR_S 968, Institut de la Vision, 75012, Paris, France.
Thibaud MathisService d'Ophtalmologie, Centre Hospitalier Universitaire de la Croix-Rousse, Hospices Civils de Lyon, Université Claude Bernard Lyon 1, 69004, Lyon, France.
Frédéric BlondSorbonne Université, INSERM, CNRS, UMR_S 968, Institut de la Vision, 75012, Paris, France.
Pauline Lagouge-RousseySorbonne Université, INSERM, CNRS, UMR_S 968, Institut de la Vision, 75012, Paris, France.
Sergio Crespo-GarciaCharité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt Universität zu Berlin, Experimental Ophthalmology, Department of Ophthalmology, Charitéplatz 1, 10117, Berlin, Germany.
Patrick M SullivanDepartment of Medicine, Centers for Aging and Geriatric Research Education and Clinical Center, Durham Veteran Affairs Medical Center, Duke University, Durham, NC, 27710, USA.
Emmanuel L GautierSorbonne Université, INSERM, UMR_S 1166, Hôpital de la Pitié-Salpêtrière, 75013, Paris, France.
Nadine ReichhartCharité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt Universität zu Berlin, Experimental Ophthalmology, Department of Ophthalmology, Charitéplatz 1, 10117, Berlin, Germany.
José-Alain SahelSorbonne Université, INSERM, CNRS, UMR_S 968, Institut de la Vision, 75012, Paris, France.
Marie E BurnsCenter for Neuroscience, Department of Cell Biology and Human Anatomy, Department of Ophthalmology and Vision Science, University of California, Davis, CA, 95616, USA.
Michel PaquesSorbonne Université, INSERM, CNRS, UMR_S 968, Institut de la Vision, 75012, Paris, France.
Torben Lykke SørensenClinical Eye Research Division, Department of Ophthalmology, Zealand University Hospital Roskilde, Roskilde, Denmark.
Olaf Strauss *Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt Universität zu Berlin, Experimental Ophthalmology, Department of Ophthalmology, Charitéplatz 1, 10117, Berlin, Germany.
Xavier Guillonneau *Sorbonne Université, INSERM, CNRS, UMR_S 968, Institut de la Vision, 75012, Paris, France.
Cécile Delarasse *Sorbonne Université, INSERM, CNRS, UMR_S 968, Institut de la Vision, 75012, Paris, France. cecile.delarasse@inserm.fr.
Florian Sennlaub *Sorbonne Université, INSERM, CNRS, UMR_S 968, Institut de la Vision, 75012, Paris, France. florian.sennlaub@inserm.fr.
Institut de la Vision · FRCentre National de la Recherche Scientifique · FRInserm · FRHumboldt-Universität zu Berlin · DECharité - Universitätsmedizin Berlin · DEFreie Universität Berlin · DEGeriatric Research Education and Clinical Center · USHospices Civils de Lyon · FRSorbonne Université · FRUniversity of California, Davis · USZealand University Hospital · DK

Funding

Agence Nationale de la Recherche ANR-10-LABX-65Agence Nationale de la Recherche ANR-15-CE14-0015-01Agence Nationale de la Recherche ANR-18-IAHU-0001
6 · The paper itself

Abstract

Age-related macular degeneration (AMD) is invariably associated with the chronic accumulation of activated mononuclear phagocytes in the subretinal space. The mononuclear phagocytes are composed of microglial cells but also of monocyte-derived cells, which promote photoreceptor degeneration and choroidal neovascularization. Infiltrating blood monocytes can originate directly from bone marrow, but also from a splenic reservoir, where bone marrow monocytes develop into angiotensin II receptor (ATR1)

Indexed as

Choroidal NeovascularizationMacular DegenerationAgedAngiotensin IIAnimalsHumansInflammationMiceMonocytesAngiotensin IIAge-related macular degenerationAngiotensinNeuroinflammationSplenic monocytes

Identifiers

PMID38233865
PMCPMC10792815
OpenAlexW4390946671

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.