Trial reportBMC oral health2024
Two‑year clinical performance of indirect restorations fabricated from CAD/CAM nano hybrid composite versus lithium disilicate in mutilated vital teeth. A randomized controlled trial.
Trial report in BMC oral health, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed.
- Clinical performance of indirect hybrid ceramic onlay restorations cemented with injectable resin composite versus dual-cure resin cement: an 18-month randomized clinical trial.BMC oral health · 2025Trial
- Effect of different finishing/polishing protocols and aging on flexural strength, roughness, and surface characteristics of definitive restorative materials for CAD/CAM.Clinical oral investigations · 2026Article
- Effect of optical impression, timing of dentin sealing application and cavity design optimization on microleakage of ceramic onlays: an in vitro study.BMC oral health · 2026Article
- Enhancing severely compromised premolar strength: role of cusp reduction design in CAD/CAM composite restorations.Odontology · 2026Article
- Comparative analysis of chemical properties and biocompatibility among high ceramic filler-based 3D printed resins, low filler-based 3D printed resins and CAD/CAM ceramics.Clinical oral investigations · 2026Article
- Direct and Semi-Direct Composite Techniques in Posterior Teeth: A Two-Year Follow-Up Comparative Study.Journal of clinical medicine · 2026Article
- Restorative Management of Molar Incisor Hypomineralization-Affected Molars With Lithium Disilicate Overlays: An 8-Year Follow-Up Case Report.Case reports in dentistry · 2026Article
- Wear Resistance and Surface Roughness of Hybrid Ceramic Crowns Compared to Lithium Disilicate: AnJournal of pharmacy & bioallied sciences · 2025Article
- The Impact of Coffee, Matcha, Protein Drinks, and Water Storage on the Microhardness and Color Stability of a Nano-Ceramic Hybrid Composite CAD/CAM Blank.Journal of functional biomaterials · 2025Article
- Effect of different cavity designs and CAD/CAM blocks on fracture resistance of maxillary premolars with MOD cavities.Odontology · 2025Article
- Two different short fiber-reinforced resin composites for extensive MOD cavities in premolars and molars.Clinical oral investigations · 2025Article
- Revolutionizing dental restorations: Insights into computer-aided design/computer-aided manufacturing materials - A systematic review.Dental research journal · 2025Review
- Advances in Dental Restorations: A Comprehensive Review of Machinable and 3D-Printed Ceramic-Reinforced Composites.Journal of esthetic and restorative dentistry : official publication of the American Academy of Esthetic Dentistry ... [et al.] · 2025Review
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
TRIAL
designThis is a randomized, controlled, superiority, double-blinded, parallel-group, two-arms trial with an allocation ratio of 1:1. The aim of this trial was to compare the two-year clinical performance of partial indirect restorations fabricated from CAD/CAM nano-hybrid composite and ceramic lithium disilicate blocks using the modified USPHS criteria.
methodsIn two parallel groups (n = 50 restorations), fifty participants having mutilated vital teeth with a minimum of two remaining walls were randomly enrolled in this trial and received indirect restorations of either nano-hybrid composite resin blocks (Brilliant, Coltene, Switzerland) or Lithium Disilicate (IPS Emax CAD). The restorations were assessed using modified USPHS criteria by two independent blinded assessors at baseline, six months, one-year and two years follow-up visits. Categorical and ordinal data were presented as frequencies and percentages. Categorical data were analyzed using the chi-square test. Ordinal data were analyzed using the Mann-Whitney U test for intergroup comparisons and Freidman's test followed by the Nemenyi post hoc test for intragroup comparisons. Numerical data were presented as mean and standard deviation values. They were analyzed for normality using the Shapiro-Wilk test. Data were found to be normally distributed and were analyzed using the independent t-test. The significance level was set at p ≤ 0.05 within all tests.
resultsForty-eight participants received the allocated intervention and completed the follow-up periods. There was a statistically significant difference between both tested materials for all USPHS criteria regarding Marginal integrity and Marginal discoloration at six-months Follow-up, but with no statistically significant difference at one- and two-year follow-up.
conclusionsBoth materials showed an acceptable, successful clinical performance along the two-years follow-up period. CLINICAL RELEVANCE: The CAD/CAM nano-hybrid composite blocks are as reliable as Lithium disilicate for restoring mutilated vital teeth.
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