Evidence map›Paper›PMID 38233538›Full record

ArticleInternational journal of obesity (2005)2024

Association of excess visceral fat and severe illness in hospitalized COVID-19 patients in Japan: a retrospective cohort study.

Yuki Goto, Yuiko Nagamine, Mariko Hanafusa, Tomoki Kawahara, Nobutoshi Nawa, Ukihide Tateishi, Yutaka Ueki, Shigeru Miyamae, Kenji Wakabayashi, Nobuyuki Nosaka and 3 more

Abstract read
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Article in International journal of obesity (2005), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Yuki GotoDepartment of Global Health Promotion, Tokyo Medical and Dental University, Tokyo, Japan.ORCID 0000-0002-4777-3911
Yuiko NagamineDepartment of Global Health Promotion, Tokyo Medical and Dental University, Tokyo, Japan.
Mariko HanafusaDepartment of Tokyo Metropolitan Health Policy Advisement, Tokyo Medical and Dental University, Tokyo, Japan.
Tomoki KawaharaDepartment of Global Health Promotion, Tokyo Medical and Dental University, Tokyo, Japan.
Nobutoshi NawaDepartment of Global Health Promotion, Tokyo Medical and Dental University, Tokyo, Japan.
Ukihide TateishiDepartment of Diagnostic Radiology and Nuclear Medicine, Tokyo Medical and Dental University, Tokyo, Japan.
Yutaka UekiDepartment of Trauma and Acute Critical Care Medical Center, Tokyo Medical and Dental University, Tokyo, Japan.
Shigeru MiyamaeDisaster Medical Care Office, Tokyo Medical and Dental University, Tokyo, Japan.
Kenji WakabayashiDepartment of Intensive Care Medicine, Tokyo Medical and Dental University, Tokyo, Japan.
Nobuyuki NosakaDepartment of Intensive Care Medicine, Tokyo Medical and Dental University, Tokyo, Japan.
Yasunari MiyazakiDepartment of Respiratory Medicine, Tokyo Medical and Dental University, Tokyo, Japan.
Shuji TohdaDepartment of Clinical Laboratory, Tokyo Medical and Dental University, Tokyo, Japan.
Takeo FujiwaraDepartment of Global Health Promotion, Tokyo Medical and Dental University, Tokyo, Japan. fujiwara.hlth@tmd.ac.jp.ORCID 0000-0002-1074-3954

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

objectivesObesity, defined by body mass index (BMI), is a well-known risk factor for the severity of coronavirus disease 2019 (COVID-19). Adipose tissue distribution has also been implicated as an important factor in the body's response to infection, and excess visceral fat (VF), which is prevalent in Japanese, may contribute significantly to the severity. Therefore, this study aimed to evaluate the association of obesity and VF with COVID-19 severe illness in Japan. SUBJECTS/

methodsThis retrospective cohort study involved 550 COVID-19 patients admitted to a tertiary care hospital with BMI and body composition data, including VF. The primary endpoint was severe illness, including death, due to COVID-19 during hospitalization. Logistic regression analysis was applied to examine the quartiles of BMI and VF on severe illness after adjusting for covariates such as age, sex, subcutaneous fat, paraspinal muscle radiodensity, and comorbidities affecting VF (COPD, cancer within 5 years, immunosuppressive agent use).

resultsThe median age was 56.0 years; 71.8% were males. During hospitalization, 82 (14.9%) experienced COVID-19 severe illness. In the multivariate logistic regression analysis, Q4 of BMI was not significantly associated with severe illness compared to Q1 of BMI (OR 1.03; 95% CI 0.37-2.86; p = 0.95). Conversely, Q3 and Q4 of VF showed a higher risk for severe illness compared to Q1 of VF (OR 2.68; 95% CI 1.01-7.11; p = 0.04, OR 3.66; 95% CI 1.30-10.26; p = 0.01, respectively). Stratified analysis by BMI and adjusted for covariates showed the positive association of VF with severe illness only in the BMI < 25 kg/m

conclusionsHigh BMI was not an independent risk factor for COVID-19 severe illness in hospitalized patients in Japan, whereas excess VF significantly influenced severe illness, especially in patients with a BMI < 25 kg/m

Indexed as

Body Mass IndexCOVID-19HospitalizationIntra-Abdominal FatSARS-CoV-2AdultAgedComorbidityFemaleHumansJapanMaleMiddle AgedObesityPandemicsRetrospective Studies

Identifiers

PMID38233538

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.