Evidence map›Paper›PMID 38233512›Full record

ArticlePediatric research2024

Associations between Social Adversity and Biomarkers of Inflammation, Stress, and Aging in Children.

Matthew S Pantell, Patricia P Silveira, Euclides José de Mendonça Filho, Holly Wing, Erika M Brown, Victoria F Keeton, Irina Pokhvisneva, Kieran J O'Donnell, John Neuhaus, Danielle Hessler and 3 more

Registry-linked trialOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pediatric research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02746393 (San Francisco General Hospital), which is not on this map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02746393 nacompletednot on this map

San Francisco General Hospital (SFGH) Health Advocates Phase II Study

TypeinterventionalSponsorUniversity of California, San FranciscoRan2016 to 2020Enrolled1,278ConditionsConditions Influencing Health Status, Social Determinants of HealthArmsHealth Advocates Program, 211 Information Sheet
3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 3 countries.

Matthew S PantellDivision of Pediatric Hospital Medicine, Department of Pediatrics, University of California, San Francisco, CA, USA. Matt.Pantell@ucsf.edu.
Patricia P SilveiraDouglas Mental Health University Institute, Douglas Research Center, McGill University, Montreal, QC, Canada.
Euclides José de Mendonça FilhoDouglas Mental Health University Institute, Douglas Research Center, McGill University, Montreal, QC, Canada.
Holly WingCenter for Health and Community, University of California, San Francisco, San Francisco, CA, USA.
Erika M BrownCalifornia Policy Lab, Berkeley, CA, USA.
Victoria F KeetonDepartment of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Francisco, 490 Illinois St, Box 2930, 94143, San Francisco, CA, USA.
Irina PokhvisnevaDouglas Mental Health University Institute, Douglas Research Center, McGill University, Montreal, QC, Canada.
Kieran J O'DonnellDouglas Mental Health University Institute, Douglas Research Center, McGill University, Montreal, QC, Canada.
John NeuhausDepartment of Epidemiology and Biostatistics, University of California, San Francisco, CA, USA.
Danielle HesslerSocial Interventions Research and Evaluation Network, University of California, San Francisco, CA, USA.
Michael J MeaneyDouglas Mental Health University Institute, Douglas Research Center, McGill University, Montreal, QC, Canada.
Nancy E AdlerCenter for Health and Community, University of California, San Francisco, San Francisco, CA, USA.
Laura M GottliebCenter for Health and Community, University of California, San Francisco, San Francisco, CA, USA.
McGill University · CAUniversity of California, San Francisco · USTraining Programs in Epidemiology and Public Health Interventions Network · USSingapore Institute for Clinical Sciences · SG

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Transdisciplinary Research Training to Reduce Disparities in Preterm Birth and Improve Maternal and Neonatal OutcomesT32HD098057 · NICHD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KUPPERMANN, MIRIAM · 2019 to 2023
$1.4M
NCATS NIH HHS UL1 TR001863NICHD NIH HHS T32 HD098057
6 · The paper itself

Abstract

backgroundPrior work has found relationships between childhood social adversity and biomarkers of stress, but knowledge gaps remain. To help address these gaps, we explored associations between social adversity and biomarkers of inflammation (interleukin-1β [IL-1β], IL-6, IL-8, tumor necrosis factor-alpha [TNF-α], and salivary cytokine hierarchical "clusters" based on the three interleukins), neuroendocrine function (cortisol, cortisone, dehydroepiandrosterone, testosterone, and progesterone), neuromodulation (N-arachidonoylethanolamine, stearoylethanolamine, oleoylethanolamide, and palmitoylethanolamide), and epigenetic aging (Pediatric-Buccal-Epigenetic clock).

methodsWe collected biomarker samples of children ages 0-17 recruited from an acute care pediatrics clinic and examined their associations with caregiver-endorsed education, income, social risk factors, and cumulative adversity. We calculated regression-adjusted means for each biomarker and compared associations with social factors using Wald tests. We used logistic regression to predict being in the highest cytokine cluster based on social predictors.

resultsOur final sample included 537 children but varied based on each biomarker. Cumulative social adversity was significantly associated with having higher levels of all inflammatory markers and with cortisol, displaying a U-shaped distribution. There were no significant relationships between cumulative social adversity and cortisone, neuromodulation biomarkers or epigenetic aging.

conclusionOur findings support prior work suggesting that social stress exposures contribute to increased inflammation in children. IMPACT: Our study is one of the largest studies examining associations between childhood social adversity and biomarkers of inflammation, neuroendocrine function, neuromodulation, and epigenetic aging. It is one of the largest studies to link childhood social adversity to biomarkers of inflammation, and the first of which we are aware to link cumulative social adversity to cytokine clusters. It is also one of the largest studies to examine associations between steroids and epigenetic aging among children, and one of the only studies of which we are aware to examine associations between social adversity and endocannabinoids among children. CLINICAL

trial registrationNCT02746393.

Indexed as

Adverse Childhood ExperiencesAgingBiomarkersInflammationStress, PsychologicalAdolescentChildChild, PreschoolCytokinesEpigenesis, GeneticFemaleHumansInfantInfant, NewbornMaleRisk FactorsBiomarkersCytokines

Identifiers

PMID38233512
PMCPMC11126389
OpenAlexW4390951685

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.