Evidence map›Paper›PMID 38233418›Full record

ArticleNature communications2024

Flexible, scalable, high channel count stereo-electrode for recording in the human brain.

Keundong Lee, Angelique C Paulk, Yun Goo Ro, Daniel R Cleary, Karen J Tonsfeldt, Yoav Kfir, John S Pezaris, Youngbin Tchoe, Jihwan Lee, Andrew M Bourhis and 14 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
14.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 53 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. A soft electrode array with reconfigurable hydrogel interfaces for high-fidelity neurophysiological monitoring during craniotomy.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  6. Ionic-Bionic Interfaces: Advancing Iontronic Strategies for Bioelectronic Sensing and Therapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Observational
  15. Article
  16. Capturing the Electrical Activity of all Cortical Neurons: Are Solutions Within Reach?Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors at 3 institutions in 1 country.

Keundong Lee *Integrated Electronics and Biointerfaces Laboratory, Department of Electrical and Computer Engineering, University of California San Diego, La Jolla, CA, 92093, USA.
Angelique C Paulk *Department of Neurology, Harvard Medical School, Boston, MA, 02114, USA.ORCID 0000-0002-4413-3417
Yun Goo Ro *Integrated Electronics and Biointerfaces Laboratory, Department of Electrical and Computer Engineering, University of California San Diego, La Jolla, CA, 92093, USA.ORCID 0000-0002-7023-086X
Daniel R ClearyIntegrated Electronics and Biointerfaces Laboratory, Department of Electrical and Computer Engineering, University of California San Diego, La Jolla, CA, 92093, USA.
Karen J TonsfeldtIntegrated Electronics and Biointerfaces Laboratory, Department of Electrical and Computer Engineering, University of California San Diego, La Jolla, CA, 92093, USA.ORCID 0000-0001-8044-8857
Yoav KfirDepartment of Neurosurgery, Harvard Medical School, Boston, MA, 02114, USA.
John S PezarisDepartment of Neurosurgery, Harvard Medical School, Boston, MA, 02114, USA.
Youngbin TchoeIntegrated Electronics and Biointerfaces Laboratory, Department of Electrical and Computer Engineering, University of California San Diego, La Jolla, CA, 92093, USA.
Jihwan LeeIntegrated Electronics and Biointerfaces Laboratory, Department of Electrical and Computer Engineering, University of California San Diego, La Jolla, CA, 92093, USA.
Andrew M BourhisIntegrated Electronics and Biointerfaces Laboratory, Department of Electrical and Computer Engineering, University of California San Diego, La Jolla, CA, 92093, USA.
Ritwik VatsyayanIntegrated Electronics and Biointerfaces Laboratory, Department of Electrical and Computer Engineering, University of California San Diego, La Jolla, CA, 92093, USA.
Joel R MartinIntegrated Electronics and Biointerfaces Laboratory, Department of Electrical and Computer Engineering, University of California San Diego, La Jolla, CA, 92093, USA.
Samantha M RussmanIntegrated Electronics and Biointerfaces Laboratory, Department of Electrical and Computer Engineering, University of California San Diego, La Jolla, CA, 92093, USA.ORCID 0000-0003-2742-5300
Jimmy C YangDepartment of Neurosurgery, Harvard Medical School, Boston, MA, 02114, USA.
Amy BaohanDepartment of Neurosurgery, Harvard Medical School, Boston, MA, 02114, USA.
R Mark RichardsonDepartment of Neurosurgery, Harvard Medical School, Boston, MA, 02114, USA.ORCID 0000-0003-2620-7387
Ziv M WilliamsDepartment of Neurosurgery, Harvard Medical School, Boston, MA, 02114, USA.ORCID 0000-0002-0017-0048
Shelley I FriedDepartment of Neurosurgery, Harvard Medical School, Boston, MA, 02114, USA.ORCID 0000-0001-6456-8656
U Hoi SangIntegrated Electronics and Biointerfaces Laboratory, Department of Electrical and Computer Engineering, University of California San Diego, La Jolla, CA, 92093, USA.
Ahmed M RaslanDepartment of Neurological Surgery, Oregon Health and Science University, Portland, OR, 97239, USA.
Sharona Ben-HaimDepartment of Neurological Surgery, University of California San Diego, La Jolla, CA, 92093, USA.
Eric HalgrenDepartment of Radiology, University of California San Diego, La Jolla, CA, 92093, USA.
Sydney S CashDepartment of Neurology, Harvard Medical School, Boston, MA, 02114, USA.ORCID 0000-0002-4557-6391
Shadi A DayehIntegrated Electronics and Biointerfaces Laboratory, Department of Electrical and Computer Engineering, University of California San Diego, La Jolla, CA, 92093, USA. sdayeh@ucsd.edu.ORCID 0000-0002-1756-1774
University of California San Diego · USHarvard University · USOregon Health & Science University · US

Funding

Thin, High-Density, High-Performance, Depth and Surface Microelectrodes for Diagnosis and Treatment of EpilepsyUG3NS123723 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DAYEH, SHADI · 2021 to 2025
$9.5M
Data Archive for the Brain Initiative (DABI)R24MH114796 · NIMH · UNIVERSITY OF SOUTHERN CALIFORNIA · PI DUNCAN, DOMINIQUE, POURATIAN, NADER · 2018 to 2023
$6.2M
Neurophysiology of Human Cortical EpilepsyR01NS062092 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI CASH, SYDNEY S · 2010 to 2021
$4.7M
Neuroscience Resident Research ProgramUE5NS065743 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI SYDNEY S CASH, Ziv Williams · 2024 to 2026
$2.6M
Bringing Light to Functional Mapping in Resective NeurosurgeryDP2EB029757 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DAYEH, SHADI · 2019 to 2019
$2.4M
Integration of High Definition Display Technologies with Platinum Nanorod Microelectrodes for Large Scale in-vivo Recording and StimulationR01NS123655 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DAYEH, SHADI · 2021 to 2021
$2.0M
Effects of intrinsic and drug-induced neuromodulation on functional brain imagingR01DA050159 · NIDA · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI DEVOR, ANNA · 2020 to 2024
$1.9M
Seizure focus delineation using spontaneous and stimulus evoked EEG featuresK24NS088568 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI CASH, SYDNEY S · 2015 to 2019
$923k
Functional Mapping of the Suprachiasmatic NucleusK99NS119291 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI TONSFELDT, KAREN JILL · 2022 to 2023
$296k
High-density microgrid development for human neural interface devicesF32MH120886 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CLEARY, DANIEL R · 2019 to 2019
$73k
NIBIB NIH HHS DP2 EB029757NIDA NIH HHS R01 DA050159NIMH NIH HHS F32 MH120886NIMH NIH HHS R24 MH114796NINDS NIH HHS K24 NS088568NINDS NIH HHS K99 NS119291NINDS NIH HHS R01 NS062092NINDS NIH HHS R01 NS123655NINDS NIH HHS UE5 NS065743NINDS NIH HHS UG3 NS123723
6 · The paper itself

Abstract

Over the past decade, stereotactically placed electrodes have become the gold standard for deep brain recording and stimulation for a wide variety of neurological and psychiatric diseases. Current electrodes, however, are limited in their spatial resolution and ability to record from small populations of neurons, let alone individual neurons. Here, we report on an innovative, customizable, monolithically integrated human-grade flexible depth electrode capable of recording from up to 128 channels and able to record at a depth of 10 cm in brain tissue. This thin, stylet-guided depth electrode is capable of recording local field potentials and single unit neuronal activity (action potentials), validated across species. This device represents an advance in manufacturing and design approaches which extends the capabilities of a mainstay technology in clinical neurology.

Indexed as

BrainNeuronsAction PotentialsElectrodesElectrodes, ImplantedHumans

Identifiers

PMID38233418
PMCPMC10794240
OpenAlexW4390954508

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.