ArticleACS chemical biology2024
Targeting the Main Protease (M
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Article in ACS chemical biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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0cells of the map it votes in
4citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
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Who cites it
4 citing papers in PubMed, 7 citations in OpenAlex.
- Next-generation inhibitors of SARS-CoV-2 MNature communications · 2026Article
- Solution Domain Dynamics of Monomeric SARS-CoV‑2 Main Protease Revealed by Optimized NMR Residual Dipolar Coupling Measurements.ACS physical chemistry Au · 2026Article
- How does NMR support SARS-CoV-2 protein-ligand interaction studies?Analytical and bioanalytical chemistry · 2026Review
- Pathogenic Proteins Through the Lens of NMR Spectroscopy: Structural and Functional Insights into Disease.Cell biochemistry and biophysics · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
32 authors at 12 institutions in 7 countries.
Nadide AltincekicInstitute for Organic Chemistry and Chemical Biology, Goethe University Frankfurt am Main, D-60438 Frankfurt, Germany.
Nathalie JoresInstitute for Organic Chemistry and Chemical Biology, Goethe University Frankfurt am Main, D-60438 Frankfurt, Germany.
Frank LöhrCenter of Biomolecular Magnetic Resonance (BMRZ), Goethe University Frankfurt am Main, D-60438 Frankfurt, Germany.ORCID 0000-0001-6399-9497
Christian RichterInstitute for Organic Chemistry and Chemical Biology, Goethe University Frankfurt am Main, D-60438 Frankfurt, Germany.
Claus EhrhardtDepartment of Biochemistry, University of Zurich, 8093 Zurich, Switzerland.
Marcel J J BlommersSavernaTherapeutics, 4105 Biel-Benken, Switzerland.
Hannes BergInstitute for Organic Chemistry and Chemical Biology, Goethe University Frankfurt am Main, D-60438 Frankfurt, Germany.
Sare ÖztürkInstitute for Organic Chemistry and Chemical Biology, Goethe University Frankfurt am Main, D-60438 Frankfurt, Germany.
Santosh L GandeInstitute for Organic Chemistry and Chemical Biology, Goethe University Frankfurt am Main, D-60438 Frankfurt, Germany.
Verena LinhardInstitute for Organic Chemistry and Chemical Biology, Goethe University Frankfurt am Main, D-60438 Frankfurt, Germany.
Julien OrtsDepartment of Pharmaceutical Sciences, University of Vienna, Josef-Holaubek-Platz 2, 1090 Vienna, Austria.ORCID 0000-0003-3287-1532
Marie Jose Abi SaadDepartment of Pharmaceutical Sciences, University of Vienna, Josef-Holaubek-Platz 2, 1090 Vienna, Austria.
Matthias BütikoferSwiss Federal Institute of Technology, Laboratory of Physical Chemistry, ETH Zurich, 8093 Zürich, Switzerland.
Janina KaderliSwiss Federal Institute of Technology, Laboratory of Physical Chemistry, ETH Zurich, 8093 Zürich, Switzerland.ORCID 0000-0002-5205-3206
B Göran KarlssonSwedish NMR Centre, Department of Chemistry and Molecular Biology, University of Gothenburg, SE40530 Göteborg, Sweden.
Ulrika BrathSwedish NMR Centre, Department of Chemistry and Molecular Biology, University of Gothenburg, SE40530 Göteborg, Sweden.
Mattias HedenströmSwedish NMR Centre, Department of Chemistry, University of Umeå, SE-90187 Umeå, Sweden.
Gerhard GröbnerSwedish NMR Centre, Department of Chemistry, University of Umeå, SE-90187 Umeå, Sweden.
Uwe H SauerProtein Production Sweden, Department of Chemistry, University of Umeå, SE-90187 Umeå, Sweden.
Anastassis PerrakisOncode Institute and Division of Biochemistry, The Netherlands Cancer Institute, 1066CX Amsterdam, The Netherlands.ORCID 0000-0002-1151-6227
Julian LangerMax Planck Institute of Biophysics, D-60438 Frankfurt am Main, Germany.ORCID 0000-0002-5190-577X
Lucia BanciMagnetic Resonance Center and Department of Chemistry, University of Florence, Via L. Sacconi 6, 50019 Sesto Fiorentino, Italy.ORCID 0000-0003-0562-5774
Francesca CantiniMagnetic Resonance Center and Department of Chemistry, University of Florence, Via L. Sacconi 6, 50019 Sesto Fiorentino, Italy.
Marco FragaiMagnetic Resonance Center and Department of Chemistry, University of Florence, Via L. Sacconi 6, 50019 Sesto Fiorentino, Italy.ORCID 0000-0002-8440-1690
Deborah GrifagniMagnetic Resonance Center and Department of Chemistry, University of Florence, Via L. Sacconi 6, 50019 Sesto Fiorentino, Italy.
Tatjana BarthelMacromolecular Crystallography, Helmholtz-Zentrum Berlin, Albert-Einstein-Str. 15, D-12489 Berlin, Germany.ORCID 0000-0002-8747-3112
Jan WollenhauptMacromolecular Crystallography, Helmholtz-Zentrum Berlin, Albert-Einstein-Str. 15, D-12489 Berlin, Germany.
Manfred S WeissMacromolecular Crystallography, Helmholtz-Zentrum Berlin, Albert-Einstein-Str. 15, D-12489 Berlin, Germany.ORCID 0000-0002-2362-7047
Angus RobertsonNIH, LCP NIDDK, Bethesda, Maryland 20892, United States.
Adriaan BaxNIH, LCP NIDDK, Bethesda, Maryland 20892, United States.ORCID 0000-0002-9809-5700
Sridhar SreeramuluInstitute for Organic Chemistry and Chemical Biology, Goethe University Frankfurt am Main, D-60438 Frankfurt, Germany.
Harald SchwalbeInstitute for Organic Chemistry and Chemical Biology, Goethe University Frankfurt am Main, D-60438 Frankfurt, Germany.ORCID 0000-0001-5693-7909
Goethe University Frankfurt · DEInteruniversity Consortium for Magnetic Resonance · ITHelmholtz-Zentrum Berlin für Materialien und Energie · DEUmeå University · SEETH Zurich · CHNational Institutes of Health · USUniversity of Vienna · ATMax Planck Institute of Biophysics · DEScience for Life Laboratory · SEThe Netherlands Cancer Institute · NLUniversity of Gothenburg · SEUniversity of Zurich · CH
Funding
Methods to accelerate protein structure determination by solution NMRZIADK029046 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI BAX, ADRIAAN · 2009 to 2025
$12.8MMethods to accelerate protein structure determination by solution NMRZ01DK029046 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI BAX, AD - · 2007 to 2008
$630kIntramural NIH HHS Z01 DK029046
Abstract
The main protease M
Indexed as
Drug DiscoverySARS-CoV-2Antiviral AgentsCatalytic DomainMagnetic Resonance SpectroscopyMolecular Docking SimulationPeptide HydrolasesProtease InhibitorsAntiviral AgentsPeptide HydrolasesProtease Inhibitors
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LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.