Evidence map›Paper›PMID 38232578›Full record

ArticleBiomaterials advances2024

Nanotextured titanium inhibits bacterial activity and supports cell growth on 2D and 3D substrate: A co-culture study.

Mohd I Ishak, Rosalia Cuahtecontzi Delint, Xiayi Liu, Wei Xu, Penelope M Tsimbouri, Angela H Nobbs, Matthew J Dalby, Bo Su

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomaterials advances, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Mohd I IshakBristol Dental School, University of Bristol, Lower Maudlin Street, Bristol BS1 2LY, UK; School of Chemistry, University of Bristol, Cantock's Close, Bristol BS8 1TS, UK.
Rosalia Cuahtecontzi DelintCentre for the Cellular Microenvironment, School of Biomedical Sciences, University of Glasgow, Glasgow G12 8QQ, UK.
Xiayi LiuBristol Dental School, University of Bristol, Lower Maudlin Street, Bristol BS1 2LY, UK.
Wei XuNational Engineering Research Center for Advanced Rolling and Intelligent Manufacturing, Institute of Engineering Technology, University of Science and Technology Beijing, Beijing 100083, China.
Penelope M TsimbouriCentre for the Cellular Microenvironment, School of Biomedical Sciences, University of Glasgow, Glasgow G12 8QQ, UK.
Angela H NobbsBristol Dental School, University of Bristol, Lower Maudlin Street, Bristol BS1 2LY, UK.
Matthew J DalbyCentre for the Cellular Microenvironment, School of Biomedical Sciences, University of Glasgow, Glasgow G12 8QQ, UK.
Bo SuBristol Dental School, University of Bristol, Lower Maudlin Street, Bristol BS1 2LY, UK. Electronic address: b.su@bristol.ac.uk.

Funding

Medical Research Council MR/S010343/1
6 · The paper itself

Abstract

Medical implant-associated infections pose a significant challenge to modern medicine, with aseptic loosening and bacterial infiltration being the primary causes of implant failure. While nanostructured surfaces have demonstrated promising antibacterial properties, the translation of their efficacy from 2D to 3D substrates remains a challenge. Here, we used scalable alkaline etching to fabricate nanospike and nanonetwork topologies on 2D and laser powder-bed fusion printed 3D titanium. The fabricated surfaces were compared with regard to their antibacterial properties against Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa, and mesenchymal stromal cell responses with and without the presence of bacteria. Finite elemental analysis assessed the mechanical properties and permeability of the 3D substrate. Our findings suggest that 3D nanostructured surfaces have potential to both prevent implant infections and allow host cell integration. This work represents a significant step towards developing effective and scalable fabrication methods on 3D substrates with consistent and reproducible antibacterial activity, with important implications for the future of medical implant technology.

Indexed as

Bacterial AdhesionTitaniumAnti-Bacterial AgentsBacteriaCoculture TechniquesSurface PropertiesAnti-Bacterial AgentsTitanium2D and 3D substrateAntibacterialBiocompatibleCo-cultureNanostructures

Identifiers

PMID38232578
PMCPMC7617543

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.