Evidence map›Paper›PMID 38232531›Full record

ArticlePsychoneuroendocrinology2024

Early life adversity in primates: Behavioral, endocrine, and neural effects.

Do P M Tromp, Andrew S Fox, Marissa K Riedel, Jonathan A Oler, Xiaojue Zhou, Patrick H Roseboom, Andrew L Alexander, Ned H Kalin

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Psychoneuroendocrinology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
2.6field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Do P M TrompDepartment of Psychiatry, University of Wisconsin, Madison, WI, USA; Neuroscience Training Program, University of Wisconsin, Madison, WI, USA; HealthEmotion Research Institute, University of Wisconsin, Madison, WI, USA.
Andrew S FoxDepartment of Psychology, University of California, Davis, CA, USA; California National Primate Research Center, University of California, Davis, CA, USA.
Marissa K RiedelDepartment of Psychiatry, University of Wisconsin, Madison, WI, USA; HealthEmotion Research Institute, University of Wisconsin, Madison, WI, USA.
Jonathan A OlerDepartment of Psychiatry, University of Wisconsin, Madison, WI, USA; HealthEmotion Research Institute, University of Wisconsin, Madison, WI, USA.
Xiaojue ZhouDepartment of Psychiatry, University of Wisconsin, Madison, WI, USA; HealthEmotion Research Institute, University of Wisconsin, Madison, WI, USA.
Patrick H RoseboomDepartment of Psychiatry, University of Wisconsin, Madison, WI, USA; HealthEmotion Research Institute, University of Wisconsin, Madison, WI, USA.
Andrew L AlexanderDepartment of Psychiatry, University of Wisconsin, Madison, WI, USA; Department of Medical Physics, University of Wisconsin, Madison, WI, USA.
Ned H KalinDepartment of Psychiatry, University of Wisconsin, Madison, WI, USA; Neuroscience Training Program, University of Wisconsin, Madison, WI, USA; HealthEmotion Research Institute, University of Wisconsin, Madison, WI, USA. Electronic address: nkalin@wisc.edu.
University of Wisconsin–Madison · USUniversity of California, Davis · US

Funding

National Institute on Aging (NIA) ColonyP51OD011107 · OD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Simon J. Atkinson · 2012 to 2026
$191.5M
WNPRC Supplemental Request for Nonhuman Primate Enclosures to Equip HIV/AIDS-Related Research FacilitiesP51OD011106 · OD · UNIVERSITY OF WISCONSIN-MADISON · PI Dorota A. Grejner-Brzezinska · 2012 to 2026
$150.7M
DEVELOPMENT AND REGULATION OF EMOTION IN PRIMATESR01MH046729 · NIMH · UNIVERSITY OF WISCONSIN-MADISON · PI Ned H Kalin · 1990 to 2026
$15.3M
Brain Mechanisms Mediating Genetic Risk For Anxiety And DepressionR01MH081884 · NIMH · UNIVERSITY OF WISCONSIN-MADISON · PI Ned H Kalin · 2008 to 2026
$14.8M
Summer Research ExperienceP50MH100031 · NIMH · UNIVERSITY OF WISCONSIN-MADISON · PI KALIN, NED H · 2013 to 2017
$10.4M
Brain Mechanisms Underlying Childhood Generalized Anxiety DisorderR21MH092581 · NIMH · UNIVERSITY OF WISCONSIN-MADISON · PI KALIN, NED H · 2012 to 2013
$405k
NIH HHS P51 OD011106NIMH NIH HHS P50 MH100031NIMH NIH HHS R01 MH046729NIMH NIH HHS R01 MH081884NIMH NIH HHS R21 MH092581
6 · The paper itself

Abstract

backgroundEvidence suggests that early life adversity is associated with maladaptive behaviors and is commonly an antecedent of stress-related psychopathology. This is particularly relevant to rearing in primate species as infant primates depend on prolonged, nurturant rearing by caregivers for normal development. To further understand the consequences of early life rearing adversity, and the relation among alterations in behavior, physiology and brain function, we assessed young monkeys that had experienced maternal separation followed by peer rearing with behavioral, endocrine and multimodal neuroimaging measures.

methods50 young rhesus monkeys were studied, half of which were rejected by their mothers and peer reared, and the other half were reared by their mothers. Assessments were performed at approximately 1.8 years of age and included: threat related behavioral and cortisol responses, cerebrospinal fluid (CSF) measurements of oxytocin and corticotropin releasing hormone (CRH), and multimodal neuroimaging measures (anatomical scans, resting functional connectivity, diffusion tensor imaging, and threat-related regional glucose metabolism).

resultsThe results demonstrated alterations across behavioral, endocrine, and neuroimaging measures in young monkeys that were reared without their mothers. At a behavioral level in response to a potential threat, peer reared animals engaged in significantly less freezing behavior (p = 0.022) along with increased self-directed behaviors (p < 0.012). Levels of oxytocin in the CSF, but not plasma, were significantly reduced in the peer reared animals (p = 0.019). No differences in plasma cortisol or CSF CRH were observed. Diffusion tensor imaging revealed significantly decreased white matter density across the brain. Exploratory correlational and permutation analyses suggest that the impact of peer rearing on behavior, endocrine and brain structural alterations are mediated by separate parallel mechanisms.

conclusionsTaken together, these results demonstrate in NHPs the importance of maternal rearing on the development of brain, behavior and hormonal systems that are linked to social functioning and adaptive responses. The findings suggest that the effects of maternal deprivation are mediated via multiple independent pathways which may account for the heterogeneity in behavioral and biological alterations observed in individuals that have experienced this early life adversity.

Indexed as

Adverse Childhood ExperiencesAnimalsCorticotropin-Releasing HormoneDiffusion Tensor ImagingFemaleHumansHydrocortisoneInfantMacaca mulattaMaternal DeprivationMothersOxytocinCorticotropin-Releasing HormoneHydrocortisoneOxytocinBehavioral assessmentEarly life adversityEndocrine measuresNeuroimaging measuresParallel biological pathwaysRhesus monkeys

Identifiers

PMID38232531
PMCPMC11179711
OpenAlexW4390629537

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.