Evidence map›Paper›PMID 38232335›Full record

ArticleNeurology2024

Racial and Ethnic Differences in the Population-Attributable Fractions of Alzheimer Disease and Related Dementias.

Song-Yi Park, Veronica Wendy Setiawan, Eileen M Crimmins, Lon R White, Anna H Wu, Iona Cheng, Burcu F Darst, Christopher A Haiman, Lynne R Wilkens, Loїc Le Marchand and 1 more

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Article in Neurology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
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  12. Multifaceted roles of APOE in Alzheimer disease.Nature reviews. Neurology · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Song-Yi ParkFrom the Population Sciences in the Pacific Program (S.-Y.P., L.R. Wilkens, L.L.M., U.L.), University of Hawaii Cancer Center, University of Hawaii at Manoa, Honolulu; Department of Population and Public Health Sciences (V.W.S., A.H.W., C.A.H.), Keck School of Medicine and Norris Comprehensive Cancer Center, and Leonard Davis School of Gerontology (E.M.C.), Andrus Gerontology Center, University of Southern California, Los Angeles; Pacific Health Research and Education Institute (L.R. White), Honolulu, HI; Department of Epidemiology and Biostatistics (I.C.), University of California, San Francisco; and Public Health Sciences Division (B.F.D.), Fred Hutchinson Cancer Center, Seattle, WA.ORCID 0000-0001-7734-5320
Veronica Wendy SetiawanFrom the Population Sciences in the Pacific Program (S.-Y.P., L.R. Wilkens, L.L.M., U.L.), University of Hawaii Cancer Center, University of Hawaii at Manoa, Honolulu; Department of Population and Public Health Sciences (V.W.S., A.H.W., C.A.H.), Keck School of Medicine and Norris Comprehensive Cancer Center, and Leonard Davis School of Gerontology (E.M.C.), Andrus Gerontology Center, University of Southern California, Los Angeles; Pacific Health Research and Education Institute (L.R. White), Honolulu, HI; Department of Epidemiology and Biostatistics (I.C.), University of California, San Francisco; and Public Health Sciences Division (B.F.D.), Fred Hutchinson Cancer Center, Seattle, WA.ORCID 0000-0001-9239-5692
Eileen M CrimminsFrom the Population Sciences in the Pacific Program (S.-Y.P., L.R. Wilkens, L.L.M., U.L.), University of Hawaii Cancer Center, University of Hawaii at Manoa, Honolulu; Department of Population and Public Health Sciences (V.W.S., A.H.W., C.A.H.), Keck School of Medicine and Norris Comprehensive Cancer Center, and Leonard Davis School of Gerontology (E.M.C.), Andrus Gerontology Center, University of Southern California, Los Angeles; Pacific Health Research and Education Institute (L.R. White), Honolulu, HI; Department of Epidemiology and Biostatistics (I.C.), University of California, San Francisco; and Public Health Sciences Division (B.F.D.), Fred Hutchinson Cancer Center, Seattle, WA.
Lon R WhiteFrom the Population Sciences in the Pacific Program (S.-Y.P., L.R. Wilkens, L.L.M., U.L.), University of Hawaii Cancer Center, University of Hawaii at Manoa, Honolulu; Department of Population and Public Health Sciences (V.W.S., A.H.W., C.A.H.), Keck School of Medicine and Norris Comprehensive Cancer Center, and Leonard Davis School of Gerontology (E.M.C.), Andrus Gerontology Center, University of Southern California, Los Angeles; Pacific Health Research and Education Institute (L.R. White), Honolulu, HI; Department of Epidemiology and Biostatistics (I.C.), University of California, San Francisco; and Public Health Sciences Division (B.F.D.), Fred Hutchinson Cancer Center, Seattle, WA.ORCID 0000-0002-5536-3867
Anna H WuFrom the Population Sciences in the Pacific Program (S.-Y.P., L.R. Wilkens, L.L.M., U.L.), University of Hawaii Cancer Center, University of Hawaii at Manoa, Honolulu; Department of Population and Public Health Sciences (V.W.S., A.H.W., C.A.H.), Keck School of Medicine and Norris Comprehensive Cancer Center, and Leonard Davis School of Gerontology (E.M.C.), Andrus Gerontology Center, University of Southern California, Los Angeles; Pacific Health Research and Education Institute (L.R. White), Honolulu, HI; Department of Epidemiology and Biostatistics (I.C.), University of California, San Francisco; and Public Health Sciences Division (B.F.D.), Fred Hutchinson Cancer Center, Seattle, WA.
Iona ChengFrom the Population Sciences in the Pacific Program (S.-Y.P., L.R. Wilkens, L.L.M., U.L.), University of Hawaii Cancer Center, University of Hawaii at Manoa, Honolulu; Department of Population and Public Health Sciences (V.W.S., A.H.W., C.A.H.), Keck School of Medicine and Norris Comprehensive Cancer Center, and Leonard Davis School of Gerontology (E.M.C.), Andrus Gerontology Center, University of Southern California, Los Angeles; Pacific Health Research and Education Institute (L.R. White), Honolulu, HI; Department of Epidemiology and Biostatistics (I.C.), University of California, San Francisco; and Public Health Sciences Division (B.F.D.), Fred Hutchinson Cancer Center, Seattle, WA.
Burcu F DarstFrom the Population Sciences in the Pacific Program (S.-Y.P., L.R. Wilkens, L.L.M., U.L.), University of Hawaii Cancer Center, University of Hawaii at Manoa, Honolulu; Department of Population and Public Health Sciences (V.W.S., A.H.W., C.A.H.), Keck School of Medicine and Norris Comprehensive Cancer Center, and Leonard Davis School of Gerontology (E.M.C.), Andrus Gerontology Center, University of Southern California, Los Angeles; Pacific Health Research and Education Institute (L.R. White), Honolulu, HI; Department of Epidemiology and Biostatistics (I.C.), University of California, San Francisco; and Public Health Sciences Division (B.F.D.), Fred Hutchinson Cancer Center, Seattle, WA.
Christopher A HaimanFrom the Population Sciences in the Pacific Program (S.-Y.P., L.R. Wilkens, L.L.M., U.L.), University of Hawaii Cancer Center, University of Hawaii at Manoa, Honolulu; Department of Population and Public Health Sciences (V.W.S., A.H.W., C.A.H.), Keck School of Medicine and Norris Comprehensive Cancer Center, and Leonard Davis School of Gerontology (E.M.C.), Andrus Gerontology Center, University of Southern California, Los Angeles; Pacific Health Research and Education Institute (L.R. White), Honolulu, HI; Department of Epidemiology and Biostatistics (I.C.), University of California, San Francisco; and Public Health Sciences Division (B.F.D.), Fred Hutchinson Cancer Center, Seattle, WA.
Lynne R WilkensFrom the Population Sciences in the Pacific Program (S.-Y.P., L.R. Wilkens, L.L.M., U.L.), University of Hawaii Cancer Center, University of Hawaii at Manoa, Honolulu; Department of Population and Public Health Sciences (V.W.S., A.H.W., C.A.H.), Keck School of Medicine and Norris Comprehensive Cancer Center, and Leonard Davis School of Gerontology (E.M.C.), Andrus Gerontology Center, University of Southern California, Los Angeles; Pacific Health Research and Education Institute (L.R. White), Honolulu, HI; Department of Epidemiology and Biostatistics (I.C.), University of California, San Francisco; and Public Health Sciences Division (B.F.D.), Fred Hutchinson Cancer Center, Seattle, WA.
Loїc Le MarchandFrom the Population Sciences in the Pacific Program (S.-Y.P., L.R. Wilkens, L.L.M., U.L.), University of Hawaii Cancer Center, University of Hawaii at Manoa, Honolulu; Department of Population and Public Health Sciences (V.W.S., A.H.W., C.A.H.), Keck School of Medicine and Norris Comprehensive Cancer Center, and Leonard Davis School of Gerontology (E.M.C.), Andrus Gerontology Center, University of Southern California, Los Angeles; Pacific Health Research and Education Institute (L.R. White), Honolulu, HI; Department of Epidemiology and Biostatistics (I.C.), University of California, San Francisco; and Public Health Sciences Division (B.F.D.), Fred Hutchinson Cancer Center, Seattle, WA.ORCID 0000-0001-5013-980X
Unhee LimFrom the Population Sciences in the Pacific Program (S.-Y.P., L.R. Wilkens, L.L.M., U.L.), University of Hawaii Cancer Center, University of Hawaii at Manoa, Honolulu; Department of Population and Public Health Sciences (V.W.S., A.H.W., C.A.H.), Keck School of Medicine and Norris Comprehensive Cancer Center, and Leonard Davis School of Gerontology (E.M.C.), Andrus Gerontology Center, University of Southern California, Los Angeles; Pacific Health Research and Education Institute (L.R. White), Honolulu, HI; Department of Epidemiology and Biostatistics (I.C.), University of California, San Francisco; and Public Health Sciences Division (B.F.D.), Fred Hutchinson Cancer Center, Seattle, WA.ORCID 0000-0001-6221-7190

Funding

Understanding Population Differences in Cancer: The MEC StudyU01CA164973 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI HAIMAN, CHRISTOPHER ALAN, LE MARCHAND, LOIC · 2015 to 2025
$37.4M
USC/UCLA Center on Biodemography &Population HealthP30AG017265 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI JENNIFER A AILSHIRE · 1999 to 2026
$17.9M
Biological Underpinnings of Socioeconomic Differentials in Health and MortalityR01AG060110 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CRIMMINS, EILEEN M · 2018 to 2022
$2.6M
NCI NIH HHS U01 CA164973NIA NIH HHS P30 AG017265NIA NIH HHS R01 AG060110
6 · The paper itself

Abstract

BACKGROUND AND

objectivesPrevious studies estimated that modifiable risk factors explain up to 40% of the dementia cases in the United States and that this population-attributable fraction (PAF) differs by race and ethnicity-estimates of future impact based on the risk factor prevalence in contemporary surveys. The aim of this study was to determine the race-specific and ethnicity-specific PAF of late-onset Alzheimer disease and related dementias (ADRDs) based on the risk factor prevalence and associations observed on the same individuals within a prospective cohort.

methodsData were from Multiethnic Cohort Study participants (African American, Japanese American, Latino, Native Hawaiian, and White) enrolled in Medicare Fee-for-Service. We estimated the PAF based on the prevalence of risk factors at cohort baseline and their mutually adjusted association with subsequent ADRD incidence. Risk factors included low educational attainment and midlife exposures to low neighborhood socioeconomic status, unmarried status, history of hypertension, stroke, diabetes or heart disease, smoking, physical inactivity, short or long sleep duration, obesity, and low-quality diet, as well as

resultsAmong 91,881 participants (mean age 59.3 at baseline, 55.0% female participants), 16,507 incident ADRD cases were identified from Medicare claims (1999-2016, mean follow-up 9.3 years). The PAF for nongenetic factors combined was similar in men (24.0% [95% CI 21.3-26.6]) and women (22.8% [20.3-25.2]) but varied across Japanese American (14.2% [11.1-17.2]), White (21.9% [19.0-24.7]), African American (27.8% [22.3-33.0]), Native Hawaiian (29.3% [21.0-36.7]), and Latino (33.3% [27.5-38.5]) groups. The combined PAF was attenuated when accounting for competing risk of death, in both men (10.4%) and women (13.9%) and across racial and ethnic groups (4.7%-25.5%). The combined PAF was also different by age at diagnosis and ADRD subtypes, higher for younger (65-74 years: 43.2%) than older (75-84 years: 32.4%; ≥85 years: 11.3%) diagnoses and higher for vascular or unspecified ADRD than for AD or Lewy body dementia. An additional PAF of 11.8% (9.9-13.6) was associated with DISCUSSION: Known risk factors explained about a third of the ADRD cases but with unequal distributions across racial and ethnic groups.

Indexed as

Alzheimer DiseaseAgedApolipoprotein E4Cohort StudiesFemaleHumansMaleMedicareMiddle AgedProspective StudiesUnited StatesApolipoprotein E4

Identifiers

PMID38232335
PMCPMC11097758

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