ArticleScience translational medicine2024
TMEM106B core deposition associates with TDP-43 pathology and is increased in risk SNP carriers for frontotemporal dementia.
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Article in Science translational medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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29citing papers in PubMed
15.1field-weighted citation impact, top 1% of its field
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Who cites it
29 citing papers in PubMed, 41 citations in OpenAlex.
- Protective TMEM106B-rs3173615 delays age at onset in GRN mutation carriers.Molecular psychiatry · 2026Article
- Associations between TMEM106B C-terminal fragment aggregation, age, and TDP-43 or tau pathology.Brain pathology (Zurich, Switzerland) · 2026Article
- TMEM106B is a selective modulator of TDP-43 pathology in Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Clinical Associations of Cerebrospinal Fluid TMEM106B in Familial and Sporadic Frontotemporal Dementia.JAMA neurology · 2026Article
- Biochemical and Immunohistochemical Associations of TDP-43 and Cryptic RNA With Hippocampal and Amygdala Volumetrics in Alzheimer's Disease.Annals of neurology · 2026Article
- TDP-43: [GU]-ardian of the transcriptome.Molecular neurodegeneration · 2026Review
- TMEM106B C-terminal fragments drive nucleocytoplasmic transport failure and TDP-43 mislocalization in the aging human brain.bioRxiv : the preprint server for biology · 2026Article
- Neurodegeneration risk variants promote lysosomal TMEM106B fibril accumulation.bioRxiv : the preprint server for biology · 2026Article
- Granulin loss and TMEM106B risk converge on lysosomal C-terminal fragment pathology in frontotemporal dementia.bioRxiv : the preprint server for biology · 2026Article
- TDP-43-mediated alternative polyadenylation is associated with a reduction in VPS35 and VPS29 expression in frontotemporal dementia.PLoS biology · 2026Article
- Lysosomal escape and TMEM106B fibrillar core determine TDP-43 seeding outcomes.bioRxiv : the preprint server for biology · 2025Article
- Genetic variation in TMEM106B alters microglial activation and cytokine responses in chronic traumatic encephalopathy.Acta neuropathologica · 2025Article
- TDP-43 nuclear loss in FTD/ALS causes widespread alternative polyadenylation changes.Nature neuroscience · 2025Article
- CTE-Type Tau Filaments in Alzheimer's Disease with Co-morbid LATE-NC.bioRxiv : the preprint server for biology · 2025Article
- Divergent and convergent TMEM106B pathology in murine models of neurodegeneration and human disease.Acta neuropathologica communications · 2025Article
- The role of endolysosomal progranulin and TMEM106B in neurodegenerative diseases.Molecular neurodegeneration · 2025Review
- Molecular mechanisms and consequences of TDP-43 phosphorylation in neurodegeneration.Molecular neurodegeneration · 2025Review
- Article
- TMEM106B deficiency leads to alterations in lipid metabolism and obesity in the TDP-43Communications biology · 2025Article
- Risk and progression of frontotemporal dementia in carriers of the TMEM106B protective genotype and its relationship with TDP-43 pathology.Annals of translational medicine · 2024Article
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Authors and funding
36 authors at 5 institutions in 1 country.
Jordan D MarksMedical Scientist Training Program, Mayo Clinic Alix School of Medicine, Rochester, MN 55905, USA.ORCID 0000-0003-0021-9689
Virginia Estades AyusoNeuroscience Graduate Program, Mayo Graduate School, Mayo Clinic College of Medicine, Jacksonville, FL 32224, USA.
Yari CarlomagnoDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.ORCID 0000-0001-5530-7737
Mei YueDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.
Tiffany W ToddDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.ORCID 0000-0003-4327-6114
Ying HaoCenter for Alzheimer's and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.ORCID 0000-0001-5053-4850
Ziyi LiCenter for Alzheimer's and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.ORCID 0000-0002-5165-8772
Zachary T McEachinCenter for Neurodegenerative Disease, Emory University School of Medicine, Atlanta, GA 30307, USA.
Anantharaman ShantaramanCenter for Neurodegenerative Disease, Emory University School of Medicine, Atlanta, GA 30307, USA.ORCID 0000-0003-1384-941X
Duc M DuongCenter for Neurodegenerative Disease, Emory University School of Medicine, Atlanta, GA 30307, USA.ORCID 0000-0001-5880-1888
Lillian M DaughrityDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.ORCID 0000-0003-4644-7265
Karen Jansen-WestDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.ORCID 0000-0002-1234-7103
Wei ShaoDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.ORCID 0000-0002-8782-4904
Anna CalliariDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.ORCID 0009-0006-6834-0425
Jesus Gonzalez BejaranoDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.ORCID 0009-0006-1677-2760
Michael DeTureDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.ORCID 0000-0002-4363-1262
Bailey RawlinsonDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.
Monica Castanedes CaseyDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.ORCID 0000-0002-8441-7801
Meredith T LilleyNeuroscience Graduate Program, Mayo Graduate School, Mayo Clinic College of Medicine, Jacksonville, FL 32224, USA.ORCID 0000-0003-0443-3607
Megan H DonahueDepartment of Neurology, Mayo Clinic, Jacksonville, FL 32224, USA.ORCID 0000-0002-3505-4338
Vidhya Maheswari JawaharDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.
Bradley F BoeveDepartment of Neurology, Mayo Clinic, Rochester, MN 55905, USA.ORCID 0000-0002-4153-8187
Ronald C PetersenDepartment of Neurology, Mayo Clinic, Rochester, MN 55905, USA.ORCID 0000-0002-8178-6601
David S KnopmanDepartment of Neurology, Mayo Clinic, Rochester, MN 55905, USA.ORCID 0000-0002-6544-066X
Björn OskarssonDepartment of Neurology, Mayo Clinic, Jacksonville, FL 32224, USA.ORCID 0000-0002-1725-9866
Neill R Graff-RadfordDepartment of Neurology, Mayo Clinic, Jacksonville, FL 32224, USA.
Zbigniew K WszolekDepartment of Neurology, Mayo Clinic, Jacksonville, FL 32224, USA.ORCID 0000-0001-5487-1053
Dennis W DicksonNeuroscience Graduate Program, Mayo Graduate School, Mayo Clinic College of Medicine, Jacksonville, FL 32224, USA.ORCID 0000-0001-7189-7917
Keith A JosephsDepartment of Neurology, Mayo Clinic, Rochester, MN 55905, USA.ORCID 0000-0003-2930-8634
Yue A QiCenter for Alzheimer's and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.ORCID 0000-0003-1914-8710
Nicholas T SeyfriedCenter for Neurodegenerative Disease, Emory University School of Medicine, Atlanta, GA 30307, USA.ORCID 0000-0002-8694-9211
Michael E WardNational Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.ORCID 0000-0002-5296-8051
Yong-Jie ZhangNeuroscience Graduate Program, Mayo Graduate School, Mayo Clinic College of Medicine, Jacksonville, FL 32224, USA.ORCID 0000-0002-9900-4313
Mercedes PrudencioNeuroscience Graduate Program, Mayo Graduate School, Mayo Clinic College of Medicine, Jacksonville, FL 32224, USA.ORCID 0000-0002-4894-4858
Leonard PetrucelliNeuroscience Graduate Program, Mayo Graduate School, Mayo Clinic College of Medicine, Jacksonville, FL 32224, USA.ORCID 0000-0003-2959-129X
Casey N CookNeuroscience Graduate Program, Mayo Graduate School, Mayo Clinic College of Medicine, Jacksonville, FL 32224, USA.ORCID 0000-0002-5963-8442
Mayo Clinic in Florida · USJacksonville College · USEmory University · USMayo Clinic · USNational Institutes of Health · US
Funding
Technology and Remote Assessment CoreU19AG063911 · NIA · MAYO CLINIC ROCHESTER · PI Bradley F Boeve · 2019 to 2026
$120.9MTDP-43 Loss-of-Function: Biology to BiomarkersP01AG019724 · NIA · UNIVERSITY OF PENNSYLVANIA · PI Jennifer Merrilees · 2002 to 2026
$67.2MResearch Education ComponentP30AG062677 · NIA · MAYO CLINIC ROCHESTER · PI NILUFER ERTEKIN-TANER · 2019 to 2026
$33.5MMechanisms of inherited neurodegenerative diseasesZIANS003155 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI WARD, MICHAEL · 2016 to 2025
$24.7MProject 3: Neuropathology of the multi-proteinopathy of c9FTD/ALS.P01NS084974 · NINDS · MAYO CLINIC JACKSONVILLE · PI PETRUCELLI, LEONARD · 2014 to 2024
$17.6MExpanding insights into FTD disease mechanismsR35NS097273 · NINDS · MAYO CLINIC JACKSONVILLE · PI PETRUCELLI, LEONARD · 2017 to 2024
$10.6MSupplement to AMP-AD Brain Proteomic Network Enhancement, Validation and Translation into CSF BiomarkersU01AG061357 · NIA · EMORY UNIVERSITY · PI LEVEY, ALLAN I, SEYFRIED, NICHOLAS THOMAS · 2018 to 2022
$9.1MHuman Biomarkers CoreU54NS123743 · NINDS · STANFORD UNIVERSITY · PI GITLER, AARON D. · 2021 to 2025
$8.2MPatient-Based Structural Biology of Tauopathies and TDP-43 Proteinopathies using Cryo-Electron Microscopy and Mass SpectrometryU01NS110438 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI FITZPATRICK, ANTHONY WILLIAM PAUL, PETRUCELLI, LEONARD · 2018 to 2022
$7.8MUnderstanding the role of TDP-43 in Alzheimers disease and FTLDR01AG037491 · NIA · MAYO CLINIC ROCHESTER · PI JOSEPHS, KEITH A · 2010 to 2024
$6.5MStathmin-2 and TDP-43 neurodegeneration in Alzheimer’s and multi-etiology dementiasRF1NS120992 · NINDS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI Keith A Josephs, Mercedes Prudencio · 2021 to 2026
$4.2MNovel genetic modifiers of C9orf72 and Tau toxicityRF1AG062077 · NIA · MAYO CLINIC ARIZONA · PI FRYER, JOHN DAVID, PETRUCELLI, LEONARD · 2019 to 2019
$4.0MNIA NIH HHS F30 AG085984NIA NIH HHS P01 AG019724NIA NIH HHS P30 AG062677NIA NIH HHS R01 AG037491NIA NIH HHS R01 AG063780NIA NIH HHS R01 AG065219NIA NIH HHS R01 AG071513NIA NIH HHS RF1 AG062077NIA NIH HHS RF1 AG062171NIA NIH HHS U01 AG061357NIA NIH HHS U19 AG063911NINDS NIH HHS P01 NS084974NINDS NIH HHS R01 NS117461NINDS NIH HHS R01 NS120992NINDS NIH HHS R21 NS127331NINDS NIH HHS R35 NS097273NINDS NIH HHS RF1 NS120992NINDS NIH HHS U01 NS110438NINDS NIH HHS U54 NS123743
Abstract
Genetic variation at the transmembrane protein 106B gene (
Indexed as
Frontotemporal DementiaDNA-Binding ProteinsHumansMembrane ProteinsNerve Tissue ProteinsPolymorphism, Single NucleotideDNA-Binding ProteinsMembrane ProteinsNerve Tissue ProteinsTARDBP protein, humanTMEM106B protein, human
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.