ArticleMikrochimica acta2024
A portable intelligent hydrogel platform for multicolor visual detection of HAase.
Zhe Zhao, Zhixin Li, Jiahui Huang, Xiaoyu Deng, Fan Jiang, Ray P S Han, Yingzhou Tao, Shaohua Xu
Abstract read
In one paragraphArticle in Mikrochimica acta, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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0 citing papers in PubMed, 7 citations in OpenAlex.
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5 · Who and what moneyAuthors and funding
8 authors at 1 institution in 1 country.
Zhe Zhao *Cancer Research Center& Jiangxi Engineering Research Center for Translational Cancer Technology, Jiangxi University of Chinese Medicine, Nanchang, 330004, Jiangxi, China.
Zhixin Li *Institute for Advanced Study, Research Center for Differentiation and Development of TCM Basic Theory, Jiangxi University of Chinese Medicine, Nanchang, 330004, Jiangxi, China.
Jiahui HuangCancer Research Center& Jiangxi Engineering Research Center for Translational Cancer Technology, Jiangxi University of Chinese Medicine, Nanchang, 330004, Jiangxi, China.
Xiaoyu DengMinistry of Education Key Laboratory of Modern Preparation of Traditional Chinese Medicine, Jiangxi University of Chinese Medicine, Nanchang, 330004, Jiangxi, China.
Fan JiangSchool of Pharmacy, Jiangxi University of Chinese Medicine, Nanchang, 330004, Jiangxi, China.
Ray P S HanCancer Research Center& Jiangxi Engineering Research Center for Translational Cancer Technology, Jiangxi University of Chinese Medicine, Nanchang, 330004, Jiangxi, China. ray-han@jxutcm.edu.cn.
Yingzhou TaoCancer Research Center& Jiangxi Engineering Research Center for Translational Cancer Technology, Jiangxi University of Chinese Medicine, Nanchang, 330004, Jiangxi, China. taoyingzhou@jxutcm.edu.cn.
Shaohua XuCancer Research Center& Jiangxi Engineering Research Center for Translational Cancer Technology, Jiangxi University of Chinese Medicine, Nanchang, 330004, Jiangxi, China. xushaohua407@163.com.ORCID http://orcid.org/0000-0003-2522-2358 Jiangxi University of Traditional Chinese Medicine · CN
Funding
Doctoral Scientific Research Foundation of Jiangxi University of Chinese Medicine 2020BSZR006Doctoral Scientific Research Foundation of Jiangxi University of Chinese Medicine 2021BSZR013Doctoral Scientific Research Foundation of Jiangxi University of Chinese Medicine 2022BSZR008National Natural Science Foundation of China 22264018Natural Science Foundation of Jiangxi Province 20224BAB213005Natural Science Foundation of Jiangxi Province 20232BAB203019Natural Science Foundation of Jiangxi Province 20232BAB216118Science and technology research project of Jiangxi Provincial Department of Education GJJ201253
6 · The paper itselfAbstract
Hyaluronidase (HAase) is an important endoglycosidase involved in numerous physiological and pathological processes, such as apoptosis, senescence, and cancer progression. Simple, convenient, and sensitive detection of HAase is important for clinical diagnosis. Herein, an easy-to-operate multicolor visual sensing strategy was developed for HAase determination. The proposed sensor was composed of an enzyme-responsive hydrogel and a nanochromogenic system (gold nanobipyramids (AuNBPs)). The enzyme-responsive hydrogel, formed by polyethyleneimine-hyaluronic acid (PEI-HA), was specifically hydrolyzed with HAase, leading to the release of platinum nanoparticles (PtNPs). Subsequently, PtNPs catalyzed the mixed system of 3,3',5,5'-tetramethylbenzidine (TMB) and H
Indexed as
BenzidinesHyaluronoglucosaminidaseMetal NanoparticlesHumansHydrogelsHydrogen PeroxidePlatinum3,3',5,5'-tetramethylbenzidineBenzidinesHyaluronoglucosaminidaseHydrogelsHydrogen PeroxidePlatinumColorimetric sensorEnzyme-responsive hydrogelGold nanobipyramidsHyaluronidase
Identifiers
PMID38231363
OpenAlexW4390952862
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