SynthesisClinical oral investigations2024
Interdental papilla reconstruction: a systematic review.
Synthesis in Clinical oral investigations, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07594184 (Efficacy of Submucosal Hyaluronic Acid Infiltration in Improving the Sensation of Dry Mouth in Patients With Xerostomia), which is not on this map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Efficacy of Submucosal Hyaluronic Acid Infiltration in Improving the Sensation of Dry Mouth in Patients With Xerostomia: A Double-Blind Randomized Clinical Trial.
Who cites it
20 citing papers in PubMed, 33 citations in OpenAlex.
- Injectable platelet-rich fibrin based interventions for treatment of gingival black triangles: systematic review of clinical evidence.Journal of the Korean Association of Oral and Maxillofacial Surgeons · 2026Review
- The "B.U.M.P." Concept: Combined Prosthetic and Surgical Approach in Esthetic Immediate Implant Placement. A Case Report.Healthcare (Basel, Switzerland) · 2026Article
- Non-Surgical Cosmetic Treatment Modalities for Interdental Papilla Reconstruction "Black Triangles": An Evidence-Based Review.Journal of cosmetic dermatology · 2026Review
- Hyaluronic acid versus microneedling with injectable platelet-rich fibrin in the treatment of partial loss of interdental papillae: A pilot randomized clinical trial.The Saudi dental journal · 2026Article
- Effects of extended guided bone regeneration on the labial alveolar wall of adjacent teeth in the anterior maxilla: a retrospective cohort study.Head & face medicine · 2026Article
- Inverted T-Shape Connective Tissue Graft for Interdental Papilla Reconstruction: A Clinical Case Series.Journal of esthetic and restorative dentistry : official publication of the American Academy of Esthetic Dentistry ... [et al.] · 2026Article
- Customized Connective Tissue Graft Technique for Optimizing Interproximal Attachment Gain in Regenerative Treatment of Infrabony Defects: A Case Report With 36- to 56-Month Follow-Up.Journal of esthetic and restorative dentistry : official publication of the American Academy of Esthetic Dentistry ... [et al.] · 2026Article
- Effectiveness of hyaluronic acid vs. surgical and non-surgical methods for Papilla Reconstruction: a systematic review.Frontiers in dental medicine · 2026Review
- Incidence of Open Gingival Embrasure During Orthodontic Treatment and Associated Factors: A Systematic Review.International journal of dentistry · 2026Review
- Article
- Root coverage using recombinant human fibroblast growth factor-2 treated connective tissue graft: Case studies.Clinical advances in periodontics · 2025Article
- The effects of polynucleotides-based biomimetic hydrogels in tissue repair: a 2D and 3DRegenerative medicine · 2025Article
- Pink esthetic treatment of gingival recession, black triangle, and gummy smile: a narrative review.Maxillofacial plastic and reconstructive surgery · 2025Review
- Clinical efficacy, aesthetic discomfort, and quality of life in patients undergoing hemolaser therapy for the treatment of papillary loss: a longitudinal pilot study.Lasers in medical science · 2025Article
- Association Between Vertical Bone Defects and Interdental Papilla Loss in Periodontitis: A Cross-Sectional Analysis.Dentistry journal · 2025Article
- Expert consensus on orthodontic treatment of patients with periodontal disease.International journal of oral science · 2025Review
- Esthetic and Functional Rehabilitation: Retreatment of Anterior Fixed Dental Prothesis With Biologically Oriented Preparation Technique and Digital Workflow.Journal of esthetic and restorative dentistry : official publication of the American Academy of Esthetic Dentistry ... [et al.] · 2025Article
- The Interaction Between Orthodontics and Periodontal Tissue Remodeling :.Galen medical journal · 2025Review
- Esthetic Management in Geminated and Supernumerary Maxillary Incisor Teeth With a Conservative Interdisciplinary Approach.Case reports in dentistry · 2025Article
- Histologic Evaluation of Early Papilla Healing after Augmentation with Injectable Hyaluronic Acid-A Proof of Concept.Journal of clinical medicine · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo assess treatment options for the reconstruction of the lost interdental papilla and to evaluate evidence for their efficacy.
methodsAn electronic search (Medline, Embase and the Cochrane Library Database and OpenGray) and a hand search were carried out to identify all types of studies investigating interdental papilla reconstruction (except for reviews) with a minimum of 3 months follow-up.
resultsForty-five studies were included in the study including 7 RCTs, 2 cohort studies, 19 case series and 17 case reports. Fifteen studies reported on the use of hyaluronic acid, 6 studies on platelet-rich fibrin, 16 studies on soft tissue grafting, 4 studies on orthodontics and 4 on additional modalities. The most common outcome measures were black triangle dimensions and papillary fill percentage. Meta-analysis was not possible due to the high heterogeneity of the studies.
conclusionThere are various options for interdental papilla reconstruction of which hyaluronic acid injections, PRF, surgical grafting and orthodontics seem to improve outcomes at a minimum 3 months. The use of soft tissue grafting with sub-epithelial connective tissue graft seems to be associated with the most robust evidence for the longer-term reduction of 'black triangles'. There is insufficient evidence to make recommendations to clinicians. Further research is needed in the form of well conducted RCTs with longer follow ups and patient reported outcome measures. CLINICAL RELEVANCE: Patients frequently complain about the appearance of black triangles and their management options seem unclear. This systematic review provides insight into the available reconstructive options.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.