Evidence map›Paper›PMID 38231291›Full record

ArticleCancer immunology, immunotherapy : CII2024

Generation and assessment of cytokine-induced killer cells for the treatment of colorectal cancer liver metastases.

Celine Man Ying Li, Yoko Tomita, Bimala Dhakal, Teresa Tin, Runhao Li, Josephine A Wright, Laura Vrbanac, Susan L Woods, Paul Drew, Timothy Price and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer immunology, immunotherapy : CII, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Celine Man Ying LiDiscipline of Surgery, Adelaide Medical School, The University of Adelaide, Adelaide, 5005, Australia.
Yoko TomitaThe Basil Hetzel Institute for Translational Health Research, The Queen Elizabeth Hospital, Adelaide, 5011, Australia.
Bimala DhakalDiscipline of Surgery, Adelaide Medical School, The University of Adelaide, Adelaide, 5005, Australia.
Teresa TinDiscipline of Surgery, Adelaide Medical School, The University of Adelaide, Adelaide, 5005, Australia.
Runhao LiThe Basil Hetzel Institute for Translational Health Research, The Queen Elizabeth Hospital, Adelaide, 5011, Australia.
Josephine A WrightPrecision Medicine, South Australian Health and Medical Research Institute, Adelaide, 5005, Australia.
Laura VrbanacDepartment of Medical Specialties, Adelaide Medical School, The University of Adelaide, Adelaide, 5005, Australia.
Susan L WoodsPrecision Medicine, South Australian Health and Medical Research Institute, Adelaide, 5005, Australia.
Paul DrewDiscipline of Surgery, Adelaide Medical School, The University of Adelaide, Adelaide, 5005, Australia.
Timothy PriceThe Basil Hetzel Institute for Translational Health Research, The Queen Elizabeth Hospital, Adelaide, 5011, Australia.
Eric SmithDiscipline of Surgery, Adelaide Medical School, The University of Adelaide, Adelaide, 5005, Australia.
Guy J MaddernDiscipline of Surgery, Adelaide Medical School, The University of Adelaide, Adelaide, 5005, Australia.
Kevin FenixDiscipline of Surgery, Adelaide Medical School, The University of Adelaide, Adelaide, 5005, Australia. kevin.fenix@adelaide.edu.au.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Colorectal cancer (CRC) is the second leading cause of cancer-related death worldwide. Cytokine-induced killer (CIK) cells are an adoptive immunotherapy reported to have strong anti-tumour activity across a range of cancers. They are a heterogeneous mix of lymphoid cells generated by culturing human peripheral blood mononuclear cells with cytokines and monoclonal antibodies in vitro. In this study, we investigated the yield and function of CIK cells generated from patients with CRC liver metastases. We first showed that CIK cells generated in serum free medium X-VIVO 15 were comparable to those from RPMI medium with 10% FBS in terms of the number and percentages of the main subsets of cells in the CIK culture, and the intracellular levels of granzyme B and perforin, and the pro-inflammatory cytokines IL-2, IFN-γ and TNF-α. The CIK cells were cytotoxic to CRC cell lines grown in 2D cultures or as spheroids, and against autologous patient-derived tumour organoids. Donor attributes such as age, sex, or prior chemotherapy exposure had no significant impact on CIK cell numbers or function. These results suggest that functional CIK cells can be generated from patients with CRC liver metastatic disease, and support further investigations into the therapeutic application of autologous CIK cells in the management of patients with CRC liver metastases.

Indexed as

Colorectal NeoplasmsCytokine-Induced Killer CellsLiver NeoplasmsAntibodies, MonoclonalCytokinesHumansAntibodies, MonoclonalCytokinesColorectal cancerCytokine-induced killer cellsLiver metastasesPatient-derived tumour organoids

Identifiers

PMID38231291
PMCPMC10794456

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.