ArticleActa neuropathologica2024
Large-scale validation of skin prion seeding activity as a biomarker for diagnosis of prion diseases.
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Article in Acta neuropathologica, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14citing papers in PubMed
4.0field-weighted citation impact, top 6% of its field
What it found
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Who cites it
14 citing papers in PubMed, 17 citations in OpenAlex.
- From a prion seed to a tree of discoveries: Byron Caughey's RT-QuIC legacy in protein misfolding research.Acta neuropathologica · 2026Review
- Cellular prion protein and its derived peptides: multifaceted roles in neurodegenerative diseases and potential as biomarkers.Cell & bioscience · 2026Review
- A Systematic Comparison of Alpha-Synuclein Seed Amplification Assays for Increasing Reproducibility.Annals of clinical and translational neurology · 2026Review
- Molecular signatures and biomarker development for limbic-predominant age-related TDP-43 encephalopathy (LATE).Acta neuropathologica · 2026Review
- Variably Protease-Sensitive Prionopathy: Two New Cases With Motor Neuron-Dementia Syndrome.Annals of clinical and translational neurology · 2026Article
- Prions and protein aggregates as pathogens, self-propagating structures, biomarkers, and therapeutic targets.Microbiology and molecular biology reviews : MMBR · 2025Review
- A noninvasive test for human prion disease using hair roots and scalp.Scientific reports · 2025Article
- Search for a genetic cause of variably protease-sensitive prionopathy.PLoS pathogens · 2025Article
- Advancing Prion Diagnostics: RT-QuIC Applications in Peripheral Tissues.Sub-cellular biochemistry · 2025Review
- Tracking Prions by RT-QuIC: An Update.Sub-cellular biochemistry · 2025Review
- Multisite Skin Biopsies vs Cerebrospinal Fluid for Prion Seeding Activity in the Diagnosis of Prion Diseases.JAMA neurology · 2024Article
- Seeding activity of skin misfolded tau as a biomarker for tauopathies.Molecular neurodegeneration · 2024Article
- Enhanced quantitation of pathological α-synuclein in patient biospecimens by RT-QuIC seed amplification assays.PLoS pathogens · 2024Article
- Differential diagnosis of mild cognitive impairment of Alzheimer's disease by Simoa p-tau181 measurements with matching plasma and CSF.Frontiers in molecular neuroscience · 2023Article
Corrections and comments
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Authors and funding
26 authors at 10 institutions in 2 countries.
Weiguanliu Zhang *Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH, 44106, USA.
Christina D Orrú *Laboratory of Persistent Viral Diseases, NIH/NIAID Rocky Mountain Laboratories, 903 S 4 St., Hamilton, MT, 59840, USA.
Aaron Foutz *Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH, 44106, USA.
Mingxuan Ding *Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH, 44106, USA.
Jue YuanDepartment of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH, 44106, USA.
Syed Zahid Ali ShahDepartment of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH, 44106, USA.
Jing ZhangDepartment of Population and Quantitative Health Science, Case Western Reserve University School of Medicine, Cleveland, OH, 44106, USA.
Keisi KotobelliNational Prion Disease Pathology Surveillance Center, Case Western Reserve University School of Medicine, Cleveland, OH, 44106, USA.
Maria GerasimenkoDepartment of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH, 44106, USA.
Tricia GillilandDepartment of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH, 44106, USA.
Wei ChenNational Prion Disease Pathology Surveillance Center, Case Western Reserve University School of Medicine, Cleveland, OH, 44106, USA.
Michelle TangDepartment of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH, 44106, USA.
Mark CohenDepartment of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH, 44106, USA.
Jiri SafarDepartment of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH, 44106, USA.
Bin XuDepartment of Pharmaceutical Sciences, North Carolina Central University, Durham, NC, 27707, USA.
Dao-Jun HongInstitute of Neurology and Department of Neurology, Jiangxi Academy of Clinical Medical Sciences, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, 330006, Jiangxi Province, China.
Li CuiDepartment of Neurology, The First Hospital of Jilin University, Changchun, 130021, Jilin Province, China.
Andrew G HughsonLaboratory of Persistent Viral Diseases, NIH/NIAID Rocky Mountain Laboratories, 903 S 4 St., Hamilton, MT, 59840, USA.
Lawrence B SchonbergerDivision of High-Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, 1600 Clifton Rd, Atlanta, GA, 30329, USA.
Curtis TatsuokaDepartment of Medicine, University of Pittsburgh, Pittsburgh, PA, 15232, USA.
Shu G ChenDepartment of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH, 44106, USA.
Justin J GreenleeVirus and Prion Research Unit, National Animal Disease Center, USDA, Agricultural Research Service, 1920 Dayton Avenue, Ames, IA, 50010, USA.
Zerui WangDepartment of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH, 44106, USA.
Brian S ApplebyDepartment of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH, 44106, USA.
Byron CaugheyLaboratory of Persistent Viral Diseases, NIH/NIAID Rocky Mountain Laboratories, 903 S 4 St., Hamilton, MT, 59840, USA. bcaughey@niaid.nih.gov.
Wen-Quan ZouDepartment of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH, 44106, USA. wenquanzou@ncu.edu.cn.ORCID 0000-0001-8062-0370
University School · USCase Western Reserve University · USJilin University · CNUniversity Hospitals of Cleveland · USAgricultural Research Service · USCenters for Disease Control and Prevention · USNorth Carolina Central University · USRocky Mountain Research (United States) · USUniversity of Alabama at Birmingham · USUniversity of Pittsburgh · US
Funding
Detection of PrionsZIAAI001086 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI CAUGHEY, BYRON · 2009 to 2025
$18.1MPeripheral Tissue Biomarker for Premorten Diagnosis of Lewy Body DementiaR01NS118760 · NINDS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI CHEN, SHU G., KRAUS, ALLISON L · 2020 to 2025
$7.4MAssessing skin biomarkers for preclinical diagnosis of PD and non-PD ParkinsonismU01NS112010 · NINDS · CASE WESTERN RESERVE UNIVERSITY · PI CHEN, SHU G., GUNZLER, STEVEN A. · 2019 to 2023
$3.7MRole of skin prions in disease transmission and diagnostic testing of human prion diseaseR01NS109532 · NINDS · CASE WESTERN RESERVE UNIVERSITY · PI KONG, QINGZHONG · 2018 to 2022
$2.9MReplication mechanism of human prionsR01NS103848 · NINDS · CASE WESTERN RESERVE UNIVERSITY · PI SAFAR, JIRI G., SUREWICZ, WITOLD K · 2018 to 2022
$2.6MReplication mechanism of human prionsR01NS074317 · NINDS · CASE WESTERN RESERVE UNIVERSITY · PI SAFAR, JIRI G., SUREWICZ, WITOLD K · 2011 to 2015
$2.6MAccessing transmissibility and diagnostic marker of skin prions.R21NS096626 · NINDS · CASE WESTERN RESERVE UNIVERSITY · PI KONG, QINGZHONG, SAFAR, JIRI G. · 2016 to 2017
$436kNCEZID CDC HHS U51 CK000100NINDS NIH HHS R01 NS074317NINDS NIH HHS R01 NS103848NINDS NIH HHS R01 NS109532NINDS NIH HHS R01 NS118760NINDS NIH HHS R21 NS096626NINDS NIH HHS U01 NS112010
Abstract
Definitive diagnosis of sporadic Creutzfeldt-Jakob disease (sCJD) relies on the examination of brain tissues for the pathological prion protein (PrP
Indexed as
Creutzfeldt-Jakob SyndromePrion DiseasesPrionsBiomarkersHumansBiomarkersPrionsBiomarkerPrionProtein misfolding cyclic amplification (PMCA)Real-time quaking-induced conversion (RT-QuIC)Seeding activitySkin
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