Evidence map›Paper›PMID 38230663›Full record

ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2024

NCAM mimetic peptide P2 synergizes with bone marrow mesenchymal stem cells in promoting functional recovery after stroke.

Xiao-Yan Lan, Xue-Song Liang, Ming-Xuan Cao, Hua-Min Qin, Cheng-Yan Chu, Johannes Boltze, Shen Li

Abstract read
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In one paragraph

Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Xiao-Yan LanDepartment of Neurology, Dalian Municipal Central Hospital, Dalian, China.ORCID 0000-0003-4741-9426
Xue-Song LiangDepartment of Neurology and Psychiatry, Beijing Shijitan Hospital, Capital Medical University, Beijing, China.
Ming-Xuan CaoDepartment of Neurology and Psychiatry, Beijing Shijitan Hospital, Capital Medical University, Beijing, China.
Hua-Min QinDepartment of Pathology, Beijing Shijitan Hospital, Capital Medical University, Beijing, China.
Cheng-Yan ChuDepartment of Neurology, Dalian Municipal Central Hospital, Dalian, China.
Johannes BoltzeSchool of Life Sciences, University of Warwick, Coventry, UK.ORCID 0000-0003-3956-4164
Shen LiDepartment of Neurology and Psychiatry, Beijing Shijitan Hospital, Capital Medical University, Beijing, China.ORCID 0000-0001-6779-9812

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The neural cell adhesion molecule (NCAM) promotes neural development and regeneration. Whether NCAM mimetic peptides could synergize with bone marrow mesenchymal stem cells (BMSCs) in stroke treatment deserves investigation. We found that the NCAM mimetic peptide P2 promoted BMSC proliferation, migration, and neurotrophic factor expression, protected neurons from oxygen-glucose deprivation through ERK and PI3K/AKT activation and anti-apoptotic mechanisms

Indexed as

Mesenchymal Stem CellsMesenchymal Stem Cell TransplantationNeural Cell Adhesion MoleculesPeptidesRecovery of FunctionStrokeAnimalsApoptosisCell ProliferationCells, CulturedInfarction, Middle Cerebral ArteryMalePhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktRatsRats, Sprague-DawleyNeural Cell Adhesion MoleculesPeptidesPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktbone marrow mesenchymal stem cellsIschemic strokemiddle cerebral artery occlusionNCAM mimetic peptideneural cell adhesion molecule

Identifiers

PMID38230663
PMCPMC11179606

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.