Evidence map›Paper›PMID 38230415›Full record

ArticleNMR in biomedicine2024

A stable, highly concentrated fluorous nanoemulsion formulation for in vivo cancer imaging via

Alexa R Heaton, Lawrence M Lechuga, Montira Tangsangasaksri, Kai D Ludwig, Sean B Fain, Sandro Mecozzi

Open access · hybridAbstract read
In one paragraph

Article in NMR in biomedicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Emerging Nanoplatforms are Effective Against Tumor Hypoxia.International journal of nanomedicine · 2026
    Review
  3. Preclinical Applications of Magnetic Resonance Imaging in Oncology.Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer · 2026
    Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Alexa R HeatonDepartment of Chemistry, University of Wisconsin-Madison, Madison, Wisconsin, USA.ORCID 0000-0003-4144-5535
Lawrence M LechugaDepartment of Medical Physics, University of Wisconsin-Madison, Madison, Wisconsin, USA.ORCID 0000-0002-7060-6126
Montira TangsangasaksriSchool of Pharmacy, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Kai D LudwigDepartment of Medical Physics, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Sean B FainDepartment of Medical Physics, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Sandro MecozziDepartment of Chemistry, University of Wisconsin-Madison, Madison, Wisconsin, USA.ORCID 0000-0003-0828-1399
University of Wisconsin–Madison · USUniversity of Iowa · US

Funding

University of Wisconsin Institute for Clinical and Translational ResearchUL1TR002373 · NCATS · UNIVERSITY OF WISCONSIN-MADISON · PI ELIZABETH S BURNSIDE, Allan R. Brasier · 2017 to 2026
$75.9M
Pulmonary Toxicology Facility CoreP30ES005605 · NIEHS · UNIVERSITY OF IOWA · PI Brandi Janssen · 1990 to 2026
$40.5M
Institutional Clinical and Translational Science AwardUL1TR000427 · NCATS · UNIVERSITY OF WISCONSIN-MADISON · PI DREZNER, MARC KENNETH · 2012 to 2016
$32.2M
U.W. RADIOLOGICAL SCIENCES TRAINING PROGRAMT32CA009206 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI Bryan Patrick Bednarz · 1985 to 2026
$12.1M
NRSA Training CoreTL1TR002375 · NCATS · UNIVERSITY OF WISCONSIN-MADISON · PI Vivek Prabhakaran · 2017 to 2026
$8.4M
Institutional Clinical and Translational Science AwardTL1TR000429 · NCATS · UNIVERSITY OF WISCONSIN-MADISON · PI DREZNER, MARC KENNETH · 2012 to 2016
$1.5M
Fluorous Nanoemulsions in Drug DeliveryR21EB021431 · NIBIB · UNIVERSITY OF WISCONSIN-MADISON · PI MECOZZI, SANDRO · 2016 to 2017
$395k
NCATS NIH HHS TL1 TR000429NCATS NIH HHS TL1 TR002375NCATS NIH HHS UL1 TR000427NCATS NIH HHS UL1 TR002373NCI NIH HHS T32 CA009206NIBIB NIH HHS R21 EB021431NIEHS NIH HHS P30 ES005605NIH HHS
6 · The paper itself

Abstract

Magnetic resonance imaging (MRI) is a routine diagnostic modality in oncology that produces excellent imaging resolution and tumor contrast without the use of ionizing radiation. However, improved contrast agents are still needed to further increase detection sensitivity and avoid toxicity/allergic reactions associated with paramagnetic metal contrast agents, which may be seen in a small percentage of the human population. Fluorine-19 (

Indexed as

Fluorine-19 Magnetic Resonance ImagingNeoplasmsAnimalsContrast MediaHumansLiverMagnetic Resonance ImagingMiceSignal-To-Noise RatioContrast Media19F‐MRIcancer diagnosticsfluorous nanoemulsionperfluoro‐[15‐crown‐5]‐ethersemifluorinated polymers

Identifiers

PMID38230415
PMCPMC10987282
OpenAlexW4390954249

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.