Evidence map›Paper›PMID 38230372›Full record

Trial reportTherapeutics and clinical risk management2024

The Efficacy and Safety of Diazepam for Intraoperative Blood Pressure Stabilization in Hypertensive Patients Undergoing Vitrectomy Under Nerve Block Anesthesia: A Prospective, Single-Center, Double-Blind, Randomized, Controlled Trial.

Tianwei Qian, Qiaoyun Gong, Yiyang Shu, Hangqi Shen, Xia Wu, Weijun Wang, Zhihua Zhang, Hui Cao, Xun Xu

Open access · goldAbstract readCase ReportsClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Therapeutics and clinical risk management, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 99% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Tianwei Qian *Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai, People's Republic of China.ORCID 0000-0002-7359-911X
Qiaoyun Gong *Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai, People's Republic of China.
Yiyang ShuDepartment of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai, People's Republic of China.
Hangqi ShenDepartment of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai, People's Republic of China.
Xia WuDepartment of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai, People's Republic of China.
Weijun WangDepartment of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai, People's Republic of China.
Zhihua ZhangDepartment of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai, People's Republic of China.
Hui CaoDepartment of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai, People's Republic of China.
Xun XuDepartment of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai, People's Republic of China.
Shanghai Jiao Tong University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: To evaluate the effectiveness and safety of diazepam in maintaining stable intraoperative blood pressure (BP) in hypertensive patients undergoing vitrectomy under nerve block anesthesia. Methods: A total of 180 hypertensive patients undergoing vitrectomy with nerve block anesthesia were randomized into two groups. The intervention group was given oral diazepam 60 min before operation, while the control group was given oral placebo 60 min before operation. The primary outcome is the effective rate of intraoperative BP control, defined as systolic blood pressure (SBP) during the operation maintained < 160 mmHg at all timepoints. The logistic regression model will be performed to analyze the compare risk factors for ineffective BP control. Results: The effective rate of intraoperative SBP control in the diazepam group was significant higher than that in the placebo group from 15 min to 70 min of the surgery ( Conclusion: This study provides robust evidence supporting the effectiveness of oral diazepam as a pre-surgery intervention in maintaining stable blood pressure during vitrectomy in hypertensive patients. Trial Registration: Chinese Clinical Trial Registry (ChiCTR), ChiCTR2100041772.

Indexed as

blood pressure stabilizationdiazepamnerve block anesthesiavitrectomy

Identifiers

PMID38230372
PMCPMC10790667
OpenAlexW4390790193

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.