Evidence map›Paper›PMID 38230218›Full record

ArticleJournal of Cancer2024

EPS15-AS1 Inhibits AKR1B1 Expression to Enhance Ferroptosis in Hepatocellular Carcinoma Cells.

Quan Man, Guoyou Zhang, Xiaojun Chen, Sa Ren Na, Siguleng Bai, Haoqiang Zhi, Ling Sun, Huifang Pang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of Cancer, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Quan ManGeneral Surgery, Tongliao City Hospital, Tongliao, Inner Mongolia, 028000, China.
Guoyou ZhangGeneral Surgery, Tongliao City Hospital, Tongliao, Inner Mongolia, 028000, China.
Xiaojun ChenDepartment of Gastroenterology, Tongliao City Hospital, Tongliao, Inner Mongolia, 028000, China.
Sa Ren NaDepartment of Pathology, Tongliao City Hospital, Tongliao, Inner Mongolia, 028000, China.
Siguleng BaiGeneral Surgery, Tongliao City Hospital, Tongliao, Inner Mongolia, 028000, China.
Haoqiang ZhiDepartment of Gastroenterology, Tongliao City Hospital, Tongliao, Inner Mongolia, 028000, China.
Ling SunDepartment of Gastroenterology, Tongliao City Hospital, Tongliao, Inner Mongolia, 028000, China.
Huifang PangDepartment of Gastroenterology, Tongliao City Hospital, Tongliao, Inner Mongolia, 028000, China.
Tongliao Academy of Agricultural Sciences · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Epidermal growth factor receptor substrate 15 (EPS15) is part of the EGFR pathway and has been implicated in various tumorigenesis. Increasing evidence suggests that long noncoding RNA (lncRNA) plays an essential role in liver hepatocellular carcinoma (LIHC) by regulating the expression of proteins and genes. Through analysis of the cancer genome atlas (TCGA) database, we found that EPS15 is highly expressed in LIHC tissue, and lncRNA EPS15-antisense1 (EPS15-AS1) decreased in LIHC cell lines. However, the function of EPS15-AS1 in LIHC is still unknown. When EPS15-AS1 was overexpressed in HepG2 cell lines, the expression of EPS15 was reduced and cell activity and invasiveness were inhibited. In addition, we observed an increase in Fe

Indexed as

AKR1B1EPS15-AS1ferroptosishepatocellular carcinoma

Identifiers

PMID38230218
PMCPMC10788721
OpenAlexW4390700076

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.