Evidence map›Paper›PMID 38229918›Full record

ArticleOsteoarthritis and cartilage open2024

"You don't put it down to arthritis": A qualitative study of the first symptoms recalled by individuals with knee osteoarthritis.

L K King, A Mahmoudian, E J Waugh, I Stanaitis, M Gomes, V Hung, C MacKay, J W Liew, Q Wang, A Turkiewicz and 8 more

Registry-linked trialAbstract read
In one paragraph

Article in Osteoarthritis and cartilage open, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07245732 (STeroid Options for RA Management), which is not on this map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07245732 phase4recruitingnot on this mapstarted 2026, after this paper: background citation

STeroid Options for RA Management (STORM-RA): Oral Versus Intramuscular Steroid Use to Control Rheumatoid Arthritis Flares: A Pragmatic Randomized Clinical Trial

TypeinterventionalSponsorSunnybrook Health Sciences CentreRan2026 to 2029Enrolled220ConditionsRheumatoid Arthritis (RA)ArmsGlucocorticoid (GC)
3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

L K KingSt. Michael's Hospital, Unity Health Toronto, Toronto, Canada.
A MahmoudianDepartment of Clinical Sciences Lund, Orthopedics, Clinical Epidemiology Unit, Lund University, Lund, Sweden.
E J WaughDepartment of Physical Therapy, University of Toronto, Toronto, Canada.
I StanaitisWomen's College Research Institute, Women's College Hospital, Toronto, Canada.
M GomesWomen's College Research Institute, Women's College Hospital, Toronto, Canada.
V HungWomen's College Research Institute, Women's College Hospital, Toronto, Canada.
C MacKayWest Park Healthcare Centre, Toronto, Canada and Department of Physical Therapy, University of Toronto, Toronto, Canada.
J W LiewBoston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.
Q WangDepartment of Orthopedics, Shanghai Sixth People's Hospital, Shanghai, China.
A TurkiewiczDepartment of Clinical Sciences Lund, Orthopedics, Clinical Epidemiology Unit, Lund University, Lund, Sweden.
I K HaugenCenter for Treatment of Rheumatic and Musculoskeletal Diseases (REMEDY), Diakonhjemmet Hospital, Oslo, Norway.
C T AppletonDepartment of Medicine and Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, The University of Western Ontario, London, Canada.
S LohmanderDepartment of Clinical Sciences Lund, Orthopedics, Lund University, Lund, Sweden.
M EnglundDepartment of Clinical Sciences Lund, Orthopedics, Clinical Epidemiology Unit, Lund University, Lund, Sweden.
J RunhaarDepartment of General Practice, Erasmus MC University Medical Center, Rotterdam, the Netherlands.
T NeogiBoston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.
G A HawkerDepartment of Medicine, University of Toronto, Toronto, Canada.
OARSI Early-stage Symptomatic Knee Osteoarthritis Initiative

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: As part of the first phase of the OARSI Early-stage Symptomatic Knee Osteoarthritis (EsSKOA) initiative, we explored the first symptoms and experiences recalled by individuals with knee osteoarthritis (OA). Design: This qualitative study, informed by qualitative description, was a secondary analysis of focus groups (n ​= ​17 groups) and one-on-one interviews (n ​= ​3) conducted in 91 individuals living with knee OA as part of an international study to better understand the OA pain experience. In each focus group or interview, participants were asked to describe their first symptoms of knee OA. We inductively coded these transcripts and conducted thematic analysis. Results: Mean age of participants was 70 years (range 47-92) and 68 ​% were female. We developed four overarching themes: Conclusions: The earliest symptoms of knee OA are frequently insidious in onset, episodic and present long before individuals present to health professionals. These results highlight challenges to identifying people with knee OA early and support the development of specific classification criteria for EsSKOA to capture individuals at an early stage.

Indexed as

Knee osteoarthritisPatient-orientated researchQualitative researchSymptoms

Identifiers

PMID38229918
PMCPMC10790080

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.