Evidence map›Paper›PMID 38229905›Full record

ArticleJournal of clinical and translational science2023

Development, implementation, and dissemination of operational innovations across the trial innovation network.

Marisha E Palm, Terri L Edwards, Cortney Wieber, Marie T Kay, Eve Marion, Leslie Boone, Angeline Nanni, Michelle Jones, Eilene Pham, Meghan Hildreth and 11 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical and translational science, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Insights from the trial innovation network's initial consultation process.Journal of clinical and translational science · 2025
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Marisha E PalmInstitute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, MA, USA.ORCID https://orcid.org/0000-0002-9760-7196
Terri L EdwardsVanderbilt Institute for Clinical and Translational Research, Vanderbilt University Medical Center, Nashville, TN, USA.
Cortney WieberInstitute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, MA, USA.
Marie T KayUniversity of Utah Health, Salt Lake City, UT, USA.
Eve MarionDuke Clinical Research Institute, Duke University School of Medicine, Durham, NC, USA.ORCID https://orcid.org/0000-0002-8559-640X
Leslie BooneVanderbilt Institute for Clinical and Translational Research, Vanderbilt University Medical Center, Nashville, TN, USA.
Angeline NanniDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Michelle JonesVanderbilt Institute for Clinical and Translational Research, Vanderbilt University Medical Center, Nashville, TN, USA.
Eilene PhamDuke Clinical Research Institute, Duke University School of Medicine, Durham, NC, USA.
Meghan HildrethDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Karen LaneDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID https://orcid.org/0000-0002-7529-0714
Nichol McBeeDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Daniel K BenjaminDuke Clinical Research Institute, Duke University School of Medicine, Durham, NC, USA.
Gordon R BernardVanderbilt Institute for Clinical and Translational Research, Vanderbilt University Medical Center, Nashville, TN, USA.
J Michael DeanUniversity of Utah Health, Salt Lake City, UT, USA.
Jamie P DwyerUniversity of Utah Health, Salt Lake City, UT, USA.
Daniel E FordInstitute for Clinical and Translational Research, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID https://orcid.org/0000-0002-2549-2289
Daniel F HanleyDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID https://orcid.org/0000-0002-9536-4258
Paul A HarrisVanderbilt Institute for Clinical and Translational Research, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID https://orcid.org/0000-0002-1744-2011
Consuelo H WilkinsVanderbilt Institute for Clinical and Translational Research, Vanderbilt University Medical Center, Nashville, TN, USA.
Harry P SelkerInstitute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, MA, USA.ORCID https://orcid.org/0000-0001-5322-7178

Funding

CTSA UM1 Program at University of UtahUM1TR004409 · NCATS · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI RACHEL HESS, Jennifer Juhl Majersik · 2023 to 2026
$21.9M
NCATS NIH HHS UM1 TR004409
6 · The paper itself

Abstract

Improving the quality and conduct of multi-center clinical trials is essential to the generation of generalizable knowledge about the safety and efficacy of healthcare treatments. Despite significant effort and expense, many clinical trials are unsuccessful. The National Center for Advancing Translational Science launched the Trial Innovation Network to address critical roadblocks in multi-center trials by leveraging existing infrastructure and developing operational innovations. We provide an overview of the roadblocks that led to opportunities for operational innovation, our work to develop, define, and map innovations across the network, and how we implemented and disseminated mature innovations.

Indexed as

clinical trial roadblocksclinical trialsCTSAinnovationTrial innovation network

Identifiers

PMID38229905
PMCPMC10790103

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.