Evidence map›Paper›PMID 38229754›Full record

ArticleACS medicinal chemistry letters2024

Exploration of Directing-Group-Assisted, Copper-Mediated Radiofluorination and Radiosynthesis of [

Dong Zhou, Wenhua Chu, Huaping Chen, Jinbin Xu

Abstract read
In one paragraph

Article in ACS medicinal chemistry letters, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Chemical science · 2026
    Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Dong ZhouDepartment of Radiology, School of Medicine, Washington University in Saint Louis, Saint Louis, Missouri 63110, United States.ORCID https://orcid.org/0000-0002-6707-4878
Wenhua ChuDepartment of Radiology, School of Medicine, Washington University in Saint Louis, Saint Louis, Missouri 63110, United States.
Huaping ChenDepartment of Radiology, School of Medicine, Washington University in Saint Louis, Saint Louis, Missouri 63110, United States.
Jinbin XuDepartment of Radiology, School of Medicine, Washington University in Saint Louis, Saint Louis, Missouri 63110, United States.ORCID https://orcid.org/0000-0002-2120-8287

Funding

Training/DisseminationP41EB025815 · NIBIB · WASHINGTON UNIVERSITY · PI Buck E. Rogers · 2018 to 2026
$12.7M
WASHINGTON UNIVERSITY CO-CLINICAL IMAGING RESEARCH RESOURCEU24CA209837 · NCI · WASHINGTON UNIVERSITY · PI Li Ding, Shunqiang Li · 2017 to 2026
$6.3M
Dissect the mechanisms of selective regional vulnerability in Lewy Body Dementias via comparative snRNA-seq analysisR01NS123571 · NINDS · WASHINGTON UNIVERSITY · PI XU, JINBIN, ZHAO, GUOYAN · 2021 to 2025
$3.6M
Imaging and Targeted Auger Radiotherapy of High-Grade GliomaR01EB029752 · NIBIB · WASHINGTON UNIVERSITY · PI GARBOW, JOEL RICHARD, ROGERS, BUCK E. · 2020 to 2023
$3.1M
POSTMORTEM VALIDATION OF BIOMARKERS FOR IMAGING PARKINSON DISEASER01NS092865 · NINDS · WASHINGTON UNIVERSITY · PI XU, JINBIN · 2016 to 2020
$1.7M
NCI NIH HHS U24 CA209837NIBIB NIH HHS P41 EB025815NIBIB NIH HHS R01 EB029752NINDS NIH HHS R01 NS092865NINDS NIH HHS R01 NS123571
6 · The paper itself

Abstract

Copper-mediated radiofluorination (CMRF) of organoboronic precursors is the method of choice for late-stage radiofluorination of aromatic compounds as positron emission tomography (PET) radiotracers. However, CMRF generally requires harsh reaction conditions, a large amount of substrates, and harsh solvents (e.g., DMA) to proceed, affording variable radiochemical yields (RCYs). Using [

Identifiers

PMID38229754
PMCPMC10788942

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.