Evidence map›Paper›PMID 38229669›Full record

ArticleFrontiers in public health2023

Enhanced drug delivery and wound healing potential of berberine-loaded chitosan-alginate nanocomposite gel: characterization and

Md Habban Akhter, Lamya Ahmad Al-Keridis, Mohd Saeed, Habibullah Khalilullah, Safia Obaidur Rab, Adel M Aljadaan, Mohammad Akhlaquer Rahman, Mariusz Jaremko, Abdul-Hamid Emwas, Sarfaraz Ahmad and 4 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in public health, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Review
  6. Research progress on pharmacological effects and bioavailability of berberine.Naunyn-Schmiedeberg's archives of pharmacology · 2024
    Review
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 10 institutions in 3 countries.

Md Habban AkhterSchool of Pharmaceutical and Population Health Informatics (SoPPHI), DIT University, Dehradun, India.
Lamya Ahmad Al-KeridisDepartment of Biology, Faculty of Science, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia.
Mohd SaeedDepartment of Biology, College of Science, University of Hail, Hail, Saudi Arabia.
Habibullah KhalilullahDepartment of Pharmaceutical Chemistry and Pharmacognosy, Unaizah College of Pharmacy Qassim University, Unaizah, Saudi Arabia.
Safia Obaidur RabDepartment of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Khalid University, Abha, Saudi Arabia.
Adel M AljadaanDepartment of Pharmacology, College of Pharmacy, Najran University, Najran, Saudi Arabia.
Mohammad Akhlaquer RahmanDepartment of Pharmaceutics and Industrial Pharmacy, College of Pharmacy, Taif University, Taif, Saudi Arabia.
Mariusz JaremkoDivision of Biological and Environmental Sciences and Engineering (BESE), King Abdullah University of Science and Technology (KAUST), Thuwal, Saudi Arabia.
Abdul-Hamid EmwasCore Labs, King Abdullah University of Science and Technology (KAUST), Thuwal, Saudi Arabia.
Sarfaraz AhmadDepartment of Clinical Pharmacy Practice, College of Pharmacy, Jazan University, Jazan, Saudi Arabia.
Nawazish AlamDepartment of Clinical Pharmacy Practice, College of Pharmacy, Jazan University, Jazan, Saudi Arabia.
Md Sajid AliDepartment of Pharmaceutics, College of Pharmacy, Jazan University, Jazan, Saudi Arabia.
Gyas KhanDepartment of Pharmacology and Toxicology, College of Pharmacy, Jazan University, Jazan, Saudi Arabia.
Obaid AfzalDepartment of Pharmaceutical Chemistry, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Al-Kharj, Saudi Arabia.
Jazan University · SAKing Abdullah University of Science and Technology · SADehradun Institute of Technology University · INKing Khalid University · SAPrince Sattam Bin Abdulaziz University · SAPrincess Nourah bint Abdulrahman University · SAQassim University · SARoyal Derby Hospital · GBTaif University · SAUniversity of Ha'il · SA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Berberine-encapsulated polyelectrolyte nanocomposite (BR-PolyET-NC) gel was developed as a long-acting improved wound healing therapy. BR-PolyET-NC was developed using an ionic gelation/complexation method and thereafter loaded into Carbopol gel. Formulation was optimized using Design-Expert® software implementing a three-level, three-factor Box Behnken design (BBD). The concentrations of polymers, namely, chitosan and alginate, and calcium chloride were investigated based on particle size and %EE. Moreover, formulation characterized

Indexed as

BerberineChitosanNanoparticlesAlginatesAnimalsMiceNanogelsSpectroscopy, Fourier Transform InfraredWound HealingAlginatesBerberineChitosanNanogelsalginateberberinechitosannanocompositenanomedicinenanotechnologypolymerwound healing

Identifiers

PMID38229669
PMCPMC10790630
OpenAlexW4390265737

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.