Evidence map›Paper›PMID 38229613›Full record

ArticleAnnals of Indian Academy of Neurology

Dysbiosis of the Beneficial Gut Bacteria in Patients with Parkinson's Disease from India.

Sujith Pavan, Sankar Prasad Gorthi, Arvind N Prabhu, Bhabatosh Das, Ankur Mutreja, Karthick Vasudevan, Vignesh Shetty, Thandavarayan Ramamurthy, Mamatha Ballal

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of Indian Academy of Neurology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
8.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 18 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 7 institutions in 2 countries.

Sujith PavanEnteric Diseases Division, Department of Microbiology, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, Karnataka, India.
Sankar Prasad GorthiDepartment of Neurology, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, Karnataka, India.
Arvind N PrabhuDepartment of Neurology, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, Karnataka, India.
Bhabatosh DasMolecular Genetics Laboratory, Centre for Human Microbial Ecology, Translational Health Sciences and Technology Institute, NCR Biotech Science Cluster, Faridabad, Haryana, India.
Ankur MutrejaEnteric Diseases Division, Department of Microbiology, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, Karnataka, India.
Karthick VasudevanDepartment of Biotechnology, School of Applied Sciences, Reva University, Bengaluru, Karnataka, India.
Vignesh ShettyEnteric Diseases Division, Department of Microbiology, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, Karnataka, India.
Thandavarayan RamamurthyDivision of Bacteriology, ICMR-National Institute of Cholera and Enteric Diseases, Kolkata, West Bengal, India.
Mamatha BallalEnteric Diseases Division, Department of Microbiology, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, Karnataka, India.
Manipal Academy of Higher Education · INBharati Vidyapeeth Deemed University · INKasturba Medical College, Manipal · INNational Institute of Cholera and Enteric Diseases · INREVA University · INTranslational Health Science and Technology Institute · INUniversity of Cambridge · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: Recent advancement in understanding neurological disorders has revealed the involvement of dysbiosis of the gut microbiota in the pathophysiology of Parkinson's disease (PD). We sequenced microbial DNA using fecal samples collected from PD cases and healthy controls (HCs) to evaluate the role of gut microbiota. Methods: Full-length bacterial 16S rRNA gene sequencing of fecal samples was performed using amplified polymerase chain reaction (PCR) products on the GridION Nanopore sequencer. Sequenced data were analyzed using web-based tools BugSeq and MicrobiomeAnalyst. Results: We found that certain bacterial families like Clostridia UCG 014, Cristensenellaceae, and Oscillospiraceae are higher in abundance, and Lachinospiracea, Coriobacteriaceae and genera associated with short-chain fatty acid production, Conclusion: Observations from this study support the other global research on the PD gut microbiome background and provide fresh insight into the gut microbial composition of PD patients from a south Indian population. We report a higher abundance of Clostridia UCG 014 group, previously not linked to PD.

Indexed as

16S rRNA gene sequencingdysbiosisgut microbiotaneurodegenerative diseaseParkinson's diseasestool

Identifiers

PMID38229613
PMCPMC10789430
OpenAlexW4388043770

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.