Observational studyDeutsches Arzteblatt international2024
The Increase in Invasive Bacterial Infections With Respiratory Transmission in Germany, 2022/2023.
Observational study in Deutsches Arzteblatt international, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 29 citations in OpenAlex.
- Multi-center investigation on the influence of clinical characteristics and molecular group A streptococci diagnostics on the management of tonsillopharyngitis in pediatric practices in Berlin-BASE study.European journal of pediatrics · 2026Trial
- Review
- [Development of the epidemiology of antibiotic-resistant pathogens in human medicine and their significance for the health system in Germany].Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz · 2026Review
- Article
- Clinical features and trends of severe paediatric group A streptococcal infections in Japan in the post-COVID-19 pandemic era.Epidemiology and infection · 2026Article
- Rising incidence of invasive bacterial infections in Belgium following the COVID-19 pandemic.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026Article
- [Recommendations for vaccination of adults for respiratory physicians].Pneumologie (Stuttgart, Germany) · 2026Review
- Multi-dimensional epidemiology of pediatric acute respiratory tract infection in Ningbo, China (2020-2024): age-specific susceptibility, pathogen dynamics, and epidemiological trends.Frontiers in cellular and infection microbiology · 2026Article
- Invasive Pneumococcal Diseases Before and After the COVID-19 Pandemic in Italy (2018-2023).Microorganisms · 2025Article
- Invasive Group A Streptococcus infections in children during the post-pandemic period: results from a multicenter study in Italy.Italian journal of pediatrics · 2025Observational
- The resilience of vaccine serotypes in adult invasive pneumococcal disease in Portugal, 2018-2023.Scientific reports · 2025Article
- Galectin-3: a novel antimicrobial host factor identified in goat nasal mucus.Veterinary research · 2025Article
- Post-COVID-19-pandemic changes and clinical characteristics of invasive group a streptococcal infections from 2015 to 2023.Infection · 2025Article
- Kinetic Patterns of Antibiotic Consumption in German Acute Care Hospitals from 2017 to 2023.Antibiotics (Basel, Switzerland) · 2025Article
- [Overlooked threat: Sepsis with an uncommon source of infection].Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2025Article
- Incidence Rates for InvasiveVaccines · 2025Article
- Streptococcal periorbital necrotizing fasciitis: Case series on a rare but potentially life-threatening entity.Heliyon · 2025Article
- Impact of an Antimicrobial Stewardship Program on Pre-Therapy Pathogen Detection Specimen Submission, Antimicrobial Use, and Resistant Pathogens: An Interrupted Time Series Analysis.Infection and drug resistance · 2025Article
- Article
- InvasivePathogens (Basel, Switzerland) · 2024Article
Corrections and comments
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Authors and funding
16 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn late 2022, health care institutions in Germany reported an unusual number of severe, invasive bacterial infections in association with a high incidence of viral respiratory infections.
methodsWe analyzed routine data on invasive infections due to Haemophilus influenzae, Neisseria meningitidis, Staphylococcus aureus, Streptococcus pneumoniae, and Streptococcus pyogenes (2017-2023) from a voluntary, laboratory-based surveillance system involving continuously participating facilities providing diagnostic routine data that cover approximately one-third of the German population.
resultsIn the first quarter (Q1) of 2023, the number of invasive S. pyogenes isolates rose by 142% (n = 837 vs. mean Q1/2017-2019 = 346, 95% CI [258; 434]), while the number of H. influenzae isolates rose by 90% (n = 209 in Q1/2023 vs. mean Q1/2017-2019 = 110, 95% CI [79; 142]), compared to pre-pandemic seasonal peak values. The number of invasive S. pneumoniae isolates was high in two quarters (n = 1732 in Q4/2022 und Q1/2023). Adults aged 55 and older and children younger than 5 years were most affected by invasive H. influenzae, S. pneumoniae, and S. pyogenes infections. N. meningitidis was most commonly found in children under age 5.
conclusionThe reason for the marked rise in invasive bacterial infections may be an increased circulation of respiratory pathogens and elevated susceptibility in the population after relaxation of the measures taken to prevent COVID-19 infection. Coinfections with respiratory viruses may have reinforced this effect. We recommend continuous surveillance, preventive measures such as raising awareness about invasive bacterial diseases, and vaccination as recommended by the German Standing Committee on Vaccinations (STIKO).
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.