ReviewMolecular psychiatry2024
Temporal imprecision of phase coherence in schizophrenia and psychosis-dynamic mechanisms and diagnostic marker.
Review in Molecular psychiatry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Schizophrenia: temporal imprecision in phase, time, and frequency domains.Schizophrenia (Heidelberg, Germany) · 2026Article
- Disrupted neural response timing and duration during hand movement preparation in schizophrenia spectrum disorder: An fMRI study.Scientific reports · 2026Article
- Diminished variability of alpha and beta band-limited power as a neural signature in schizophrenia.Translational psychiatry · 2026Article
- Passage of Time or Delay Signal at the Level of Milliseconds: A New Approach and a Selective Difficulty in Individuals With Schizophrenia.Schizophrenia bulletin · 2026Article
- Dynamics of thoughts-novel candidate marker for differential-diagnosis of mental disorders?Journal of psychiatry & neuroscience : JPN · 2026Review
- Cerebellar dysconnectivity in schizophrenia spectrum: task-based functional connectivity analysis and cognitive stratification.Frontiers in psychiatry · 2026Article
- Learning evoked centrality dynamics in the schizophrenia brain: entropy, heterogeneity, and inflexibility of brain networks.Journal of psychiatry & neuroscience : JPN · 2025Article
- From neuronal to mental topography - Neurophenomenology of auditory hallucinations.Translational psychiatry · 2025Review
- Schizophrenia Following Early Adolescence Prodrome: A Neurodevelopmental Subtype With Autism-like Sensorimotor and Social Cognition Deficits.Schizophrenia bulletin · 2025Article
- Mapping EEG Metrics to Human Affective and Cognitive Models: An Interdisciplinary Scoping Review from a Cognitive Neuroscience Perspective.Biomimetics (Basel, Switzerland) · 2025Review
- Abnormal phase-amplitude coupling in patients with first-episode schizophrenia during the auditory steady-state response and resting states.Medical & biological engineering & computing · 2025Article
- Temporal imprecision and its dynamics in schizophrenia.Translational psychiatry · 2025Article
- Increased intra-subject variability in reward behavior relates to symptom severity in schizophrenia.Schizophrenia (Heidelberg, Germany) · 2025Article
- Task difficulty modulates the effect of mind wandering on phase dynamics.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- What Constitutes the Personal Space in Schizophrenia? Converging Subjective Experience, Brain, and Social Environment.Schizophrenia bulletin · 2025Article
- Spurious autobiographical memories of psychosis: a dopamine-gated neuroplasticity account for relapse and treatment-resistant psychosis.Psychological medicine · 2025Review
- Increasing the Construct Validity of Computational Phenotypes of Mental Illness Through Active Inference and Brain Imaging.Brain sciences · 2024Review
- Irregularity of visual motion perception and negative symptoms in schizophrenia.Schizophrenia (Heidelberg, Germany) · 2024Article
- Neural activity responsiveness by maturation of inhibition underlying critical period plasticity.Frontiers in neural circuits · 2024Article
- Effects and neural mechanisms of different physical activity on major depressive disorder based on cerebral multimodality monitoring: a narrative review.Frontiers in human neuroscience · 2024Review
Corrections and comments
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Authors and funding
2 authors.
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Abstract
Schizophrenia (SCZ) is a complex disorder in which various pathophysiological models have been postulated. Brain imaging studies using EEG/MEG and fMRI show altered amplitude and, more recently, decrease in phase coherence in response to external stimuli. What are the dynamic mechanisms of such phase incoherence, and can it serve as a differential-diagnostic marker? Addressing this gap in our knowledge, we uniquely combine a review of previous findings, novel empirical data, and computational-dynamic simulation. The main findings are: (i) the review shows decreased phase coherence in SCZ across a variety of different tasks and frequencies, e.g., task- and frequency-unspecific, which is further supported by our own novel data; (ii) our own data demonstrate diagnostic specificity of decreased phase coherence for SCZ as distinguished from major depressive disorder; (iii) simulation data exhibit increased phase offset in SCZ leading to a precision index, in the millisecond range, of the phase coherence relative to the timing of the external stimulus. Together, we demonstrate the key role of temporal imprecision in phase coherence of SCZ, including its mechanisms (phase offsets, precision index) on the basis of which we propose a phase-based temporal imprecision model of psychosis (PTP). The PTP targets a deeper dynamic layer of a basic disturbance. This converges well with other models of psychosis like the basic self-disturbance and time-space experience changes, as discussed in phenomenological and spatiotemporal psychopathology, as well as with the models of aberrant predictive coding and disconnection as in computational psychiatry. Finally, our results show that temporal imprecision as manifest in decreased phase coherence is a promising candidate biomarker for clinical differential diagnosis of SCZ, and more broadly, psychosis.
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