Evidence map›Paper›PMID 38228888›Full record

ArticleMolecular psychiatry2024

An ancient polymorphic regulatory region within the BDNF gene associated with obesity modulates anxiety-like behaviour in mice and humans.

Andrew R McEwan, Benjamin Hing, Johanna C Erickson, Greg Hutchings, Charity Urama, Emily Norton-Hughes, Mariam D'Ippolito, Susan Berry, Mirela Delibegovic, Felix Grassmann and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular psychiatry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Anxiolytic Effects ofFoods (Basel, Switzerland) · 2025
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Andrew R McEwanSchool of Medicine, Medical Sciences and Nutrition, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, AB24 2ZD, UK.ORCID 0000-0002-9918-4289
Benjamin HingDepartment of Psychiatry, Carver College of Medicine, University of Iowa, Iowa City, IA, USA.
Johanna C EricksonSchool of Medicine, Medical Sciences and Nutrition, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, AB24 2ZD, UK.
Greg HutchingsSchool of Medicine, Medical Sciences and Nutrition, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, AB24 2ZD, UK.
Charity UramaSchool of Medicine, Medical Sciences and Nutrition, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, AB24 2ZD, UK.
Emily Norton-HughesSchool of Medicine, Medical Sciences and Nutrition, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, AB24 2ZD, UK.
Mariam D'IppolitoSchool of Medicine, Medical Sciences and Nutrition, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, AB24 2ZD, UK.
Susan BerrySchool of Medicine, Medical Sciences and Nutrition, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, AB24 2ZD, UK.
Mirela DelibegovicSchool of Medicine, Medical Sciences and Nutrition, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, AB24 2ZD, UK.ORCID 0000-0001-6193-3152
Felix GrassmannInstitute for Clinical Research and Systems Medicine, Health and Medical University, Potsdam, Germany.
Alasdair MacKenzieSchool of Medicine, Medical Sciences and Nutrition, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, AB24 2ZD, UK. mbi167@abdn.ac.uk.

Funding

Medical Research Scotland PhD-50366-2021RCUK | Biotechnology and Biological Sciences Research Council (BBSRC) BB/W017598/1
6 · The paper itself

Abstract

Obesity and anxiety are morbidities notable for their increased impact on society during the recent COVID-19 pandemic. Understanding the mechanisms governing susceptibility to these conditions will increase our quality of life and resilience to future pandemics. In the current study, we explored the function of a highly conserved regulatory region (BE5.1) within the BDNF gene that harbours a polymorphism strongly associated with obesity (rs10767664; p = 4.69 × 10

Indexed as

AnxietyBrain-Derived Neurotrophic FactorObesityPolymorphism, Single NucleotideAllelesAmygdalaAnimalsBehavior, AnimalCOVID-19FemaleGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansHypothalamusMaleMiceBDNF protein, humanBdnf protein, mouseBrain-Derived Neurotrophic Factor

Identifiers

PMID38228888
PMCPMC11153140

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.