Evidence map›Paper›PMID 38228884›Full record

ArticleEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery2024

Choice of surgery in intestinal-type adenocarcinoma of the sinonasal tract: a long-term comparative study.

Tijl Vermassen, Stijn De Keukeleire, Michael Saerens, Sylvester Heerwegh, Jens M Debacker, Wouter Huvenne, Philippe Deron, David Creytens, Liesbeth Ferdinande, Sylvie Rottey and 3 more

Open access · greenAbstract readComparative Study
PubMed Publisher
In one paragraph

Article in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
3.4field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

  1. Surgical margin assessment and prognostic impact in sinonasal cancers: a systematic review and meta-analysis.Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale · 2025
    Pooled it
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Tijl Vermassen *Department Medical Oncology, University Hospital Ghent, Corneel Heymanslaan 10, Ghent, Belgium. tijl.vermassen@uzgent.be.ORCID http://orcid.org/0000-0002-1335-9966
Stijn De Keukeleire *Department Internal Medicine, University Hospital Brussels, Brussels, Belgium.ORCID http://orcid.org/0000-0001-8380-0414
Michael SaerensDepartment Medical Oncology, University Hospital Ghent, Corneel Heymanslaan 10, Ghent, Belgium.ORCID http://orcid.org/0000-0001-5523-6537
Sylvester HeerweghDepartment Medical Oncology, University Hospital Ghent, Corneel Heymanslaan 10, Ghent, Belgium.ORCID http://orcid.org/0000-0002-0238-1260
Jens M DebackerCancer Research Institute Ghent, Ghent, Belgium.ORCID http://orcid.org/0000-0002-8293-2885
Wouter HuvenneCancer Research Institute Ghent, Ghent, Belgium.ORCID http://orcid.org/0000-0002-0567-8983
Philippe DeronDepartment Head and Neck Surgery, University Hospital Ghent, Ghent, Belgium.ORCID http://orcid.org/0000-0003-1703-4410
David CreytensCancer Research Institute Ghent, Ghent, Belgium.ORCID http://orcid.org/0000-0002-6064-1673
Liesbeth FerdinandeDepartment Pathology, University Hospital Ghent, Ghent, Belgium.
Sylvie RotteyDepartment Medical Oncology, University Hospital Ghent, Corneel Heymanslaan 10, Ghent, Belgium.ORCID http://orcid.org/0000-0003-2060-3725
Claus BachertUpper Airway Research Laboratory, Ghent University, Ghent, Belgium.ORCID http://orcid.org/0000-0003-4742-1665
Fréderic DuprezCancer Research Institute Ghent, Ghent, Belgium.ORCID http://orcid.org/0000-0002-7633-1960
Thibaut Van ZeleUpper Airway Research Laboratory, Ghent University, Ghent, Belgium.ORCID http://orcid.org/0000-0002-6031-4293
Ghent University Hospital · BEVrije Universiteit Brussel · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeIntestinal-type adenocarcinoma (ITAC) is a rare sinonasal malignancy. Curative treatment requires multidisciplinary approach, with surgical options consist of the endonasal endoscopic approach (EEA) and external surgery (EXTS). Here, we provide the post-operative and survival results from a single-center long-term follow-up.

methodsWe report long-term follow-up of 92 ITAC cases treated between 1998 and 2018, treated with EEA (n = 40) or EXTS (n = 52). Survival estimates, post-operative complications and duration of hospitalization were compared between surgical modalities.

resultsBaseline characteristics were similar. A higher number of T4b tumors (16%), and subsequently more tumoral invasion (39%), was present in patients undergoing EXTS compared to EEA (3% and 18%, respectively). No difference in Barnes histology subtypes was noticed. Patients undergoing EEA had a shorter post-operative hospitalization stay versus EXTS (4 versus 7 days). Use of EEA was associated to improved disease-specific survival (DSS; 11.4 versus 4.4 years; HR

conclusionsLong-term follow-up in locally advanced ITAC demonstrates that resection by EEA is correlated with improved DSS compared to EXTS, especially for T3-4 tumors. No significant differences between both treatment modalities was observed regarding per- and post-operative complications, although hospitalization in patients undergoing EEA was shorter than for patients treated with EXTS. These results confirm that EEA should remain the preferred surgical procedure in operable cases of sinonasal ITAC.

Indexed as

AdenocarcinomaParanasal Sinus NeoplasmsAdultAgedEndoscopyFemaleFollow-Up StudiesHumansLength of StayMaleMiddle AgedNeoplasm StagingPostoperative ComplicationsRetrospective StudiesSurvival RateIntestinal-type adenocarcinomaPrognosisSinus carcinomaSurgery

Identifiers

PMID38228884
OpenAlexW4390908334

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.