Evidence map›Paper›PMID 38228809›Full record

ArticleProstate cancer and prostatic diseases2025

Quality of information and appropriateness of Open AI outputs for prostate cancer.

Riccardo Lombardo, Giacomo Gallo, Jordi Stira, Beatrice Turchi, Giuseppe Santoro, Sara Riolo, Matteo Romagnoli, Antonio Cicione, Giorgia Tema, Antonio Pastore and 6 more

Abstract read
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In one paragraph

Article in Prostate cancer and prostatic diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. Article
  2. Best of 2025 in prostate cancer and prostatic diseases.Prostate cancer and prostatic diseases · 2026
    Article
  3. Article
  4. Article
  5. The Impact of Access to Clinical Guidelines on LLM-Based Treatment Recommendations for Chronic Hepatitis B.Liver international : official journal of the International Association for the Study of the Liver · 2025
    Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Patient- and clinician-based evaluation of large language models for patient education in prostate cancer radiotherapy.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2025
    Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Riccardo LombardoDepartment of Urology, 'Sapienza' University of Rome, Rome, Italy. rlombardo@me.com.ORCID http://orcid.org/0000-0003-2890-3159
Giacomo GalloDepartment of Urology, 'Sapienza' University of Rome, Rome, Italy.
Jordi StiraDepartment of Urology, 'Sapienza' University of Rome, Rome, Italy.
Beatrice TurchiDepartment of Urology, 'Sapienza' University of Rome, Rome, Italy.
Giuseppe SantoroDepartment of Urology, 'Sapienza' University of Rome, Rome, Italy.
Sara RioloDepartment of Urology, 'Sapienza' University of Rome, Rome, Italy.
Matteo RomagnoliDepartment of Urology, 'Sapienza' University of Rome, Rome, Italy.
Antonio CicioneDepartment of Urology, 'Sapienza' University of Rome, Rome, Italy.
Giorgia TemaDepartment of Urology, 'Sapienza' University of Rome, Rome, Italy.
Antonio PastoreDepartment of Urology, 'Sapienza' University of Rome, Rome, Italy.
Yazan Al SalhiDepartment of Urology, 'Sapienza' University of Rome, Rome, Italy.
Andrea FuschiDepartment of Urology, 'Sapienza' University of Rome, Rome, Italy.
Giorgio FrancoDepartment of Urology, 'Sapienza' University of Rome, Rome, Italy.
Antonio NacchiaDepartment of Urology, 'Sapienza' University of Rome, Rome, Italy.
Andrea TubaroDepartment of Urology, 'Sapienza' University of Rome, Rome, Italy.
Cosimo De NunzioDepartment of Urology, 'Sapienza' University of Rome, Rome, Italy.ORCID http://orcid.org/0000-0002-2190-512X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chat-GPT, a natural language processing (NLP) tool created by Open-AI, can potentially be used as a quick source for obtaining information related to prostate cancer. This study aims to analyze the quality and appropriateness of Chat-GPT's responses to inquiries related to prostate cancer compared to those of the European Urology Association's (EAU) 2023 prostate cancer guidelines. Overall, 195 questions were prepared according to the recommendations gathered in the prostate cancer section of the EAU 2023 Guideline. All questions were systematically presented to Chat-GPT's August 3 Version, and two expert urologists independently assessed and assigned scores ranging from 1 to 4 to each response (1: completely correct, 2: correct but inadequate, 3: a mix of correct and misleading information, and 4: completely incorrect). Sub-analysis per chapter and per grade of recommendation were performed. Overall, 195 recommendations were evaluated. Overall, 50/195 (26%) were completely correct, 51/195 (26%) correct but inadequate, 47/195 (24%) a mix of correct and misleading and 47/195 (24%) incorrect. When looking at different chapters Open AI was particularly accurate in answering questions on follow-up and QoL. Worst performance was recorded for the diagnosis and treatment chapters with respectively 19% and 30% of the answers completely incorrect. When looking at the strength of recommendation, no differences in terms of accuracy were recorded when comparing weak and strong recommendations (p > 0,05). Chat-GPT has a poor accuracy when answering questions on the PCa EAU guidelines recommendations. Future studies should assess its performance after adequate training.

Indexed as

Artificial IntelligenceNatural Language ProcessingProstatic NeoplasmsHumansMalePractice Guidelines as Topic

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.