ArticleScientific reports2024
Chemical basis of microbiome preference in the nematode C. elegans.
Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- The WormFood CURE: Screening for bioactive metabolites that antagonize thebioRxiv : the preprint server for biology · 2026Article
- MAPK/PMK-1 innate immune signaling protects the nematode Caenorhabditis elegans from increased intestinal colonization in an animal host-pathogen model in space.NPJ microgravity · 2026Article
- Identification of bacterial signals that modulate enteric sensory neurons to influence behavior in C. elegans.Current biology : CB · 2026Article
- Article
- Caenorhabditis elegans as an experimental model for resilience-boosting microbiota interventions in nonmodel ectotherms.FEMS microbiology reviews · 2026Review
- Satiety, TAX-4, and OSM-9 tune the attraction of Caenorhabditis elegans nematodes to microbial fermentation products.G3 (Bethesda, Md.) · 2025Article
- Identification of bacterial signals that modulate enteric sensory neurons to influence behavior inbioRxiv : the preprint server for biology · 2025Article
- Gut microbiota mitigate the reproductive toxicity of silver nanoparticles through thiamine-derived metabolites.Nature communications · 2025Article
- Scent of death: Emission and behavioral role of 1-nonene in entomopathogenic nematode Steinernema kraussei.PloS one · 2025Article
- Distinct biogeographic patterns for bacteria and fungi in association withMicrobiology spectrum · 2024Article
- Selenium-EnrichedAntioxidants (Basel, Switzerland) · 2024Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Animals are exposed to many microbes in their environment, some of which have been shown to colonize various tissues including the intestine. The composition of the intestinal microbiota affects many aspects of the host's physiology and health. Despite this, very little is known about whether host behavior contributes to the colonization. We approach this question in the nematode C. elegans, which feeds on bacteria and also harbors an intestinal microbiome. We examined the behavior of C. elegans towards CeMbio, a simplified microbiome consisting of twelve strains that represent the bacteria found in the animal's natural environment. We observed that C. elegans raised on E. coli shows a strong preference for three members of CeMbio (Lelliottia amnigena JUb66, Enterobacter hormaechei CEent1, and Pantoea nemavictus BIGb0393) compared to E. coli. Previously, these three bacterial strains have been shown to support faster C. elegans development time than E. coli OP50 and are low colonizers compared to eight other members of CeMbio. We then used gas chromatography coupled to mass spectrometry to identify that these three bacteria release isoamyl alcohol, a previously described C. elegans chemoattractant. We suggest that C. elegans seeks bacteria that release isoamyl alcohol and support faster growth.
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