ArticleScientific reports2024
Golgi-targeting viscosity probe for the diagnosis of Alzheimer's disease.
Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed, 22 citations in OpenAlex.
- Endoplasmic reticulum-targeted multifunctional fluorescence probe for the determination of peroxynitrite, viscosity and alcohol content.Mikrochimica acta · 2026Article
- Golgi-Targeted Viscosity Fluorescent Probe for Monitoring Acute Lung Injury.Chemistry (Weinheim an der Bergstrasse, Germany) · 2025Article
- Small-molecule probes for imaging and impairing the Golgi apparatus in cancer.RSC medicinal chemistry · 2025Review
- Single-particle tracking of genetically encoded nanoparticles: Optimizing expression for cytoplasmic diffusion studies.Biophysical journal · 2025Article
- A dual-response fluorescence sensor for SORSC advances · 2024Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
Early diagnosis and intervention of Alzheimer's disease (AD) are particularly important to delay the pathological progression. Although fluorescent probes have been widely employed for investigating and diagnosing AD, their biological applications are significantly restricted due to the low penetration ability of the blood-brain barrier (BBB) in vivo. In this study, we reported the first Golgi-targeted two-photon (TP) fluorescent probe, DCM-DH, for detecting viscosity in the Golgi apparatus. The probe was rationally designed to exhibit superior analytical performance including high sensitivity, specific Golgi-targeting, efficient BBB penetration ability, and deep tissue penetration (247 μm) in the brains of AD model mice. Using the probe, we demonstrated that the fluorescence intensity in the human liver cancer cell (HepG2 cells) was higher than that of human normal liver cell (LO2 cells), and the brain viscosity of AD model mice increased significantly. We anticipate that this competent tool could be easily extended to other AD biomarkers for fundamental research on this detrimental disease.
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Registered trials
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