ArticleNature communications2024
The Piezo channel is a mechano-sensitive complex component in the mammalian inner ear hair cell.
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Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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20citing papers in PubMed, 1 pooled it
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- Discovering Age- and Sex-Specific Genetic Risk Factors in Sensorineural Hearing Loss: Genome-Wide Evidence from Large-Scale Biobanks.Journal of the Association for Research in Otolaryngology : JARO · 2026Pooled it
- Acbd7 is essential for preserving hair cell-mediated auditory and vestibular function.Experimental & molecular medicine · 2026Article
- Molecular identity of the mechanotransduction machinery in inner ear hair cells and mechanotransduction-linked hearing loss.Fundamental research · 2026Review
- Dynamical and Stochastic Analysis of a Piezoelectric Neuron Model for Intelligent Sensing Applications.Sensors (Basel, Switzerland) · 2026Article
- PIEZO1 in Immune Cells: From Force to Function.Results and problems in cell differentiation · 2026Review
- Piezo2 in Mechanosensory Biology: From Physiological Homeostasis to Disease-Promoting Mechanisms.Cell proliferation · 2026Review
- Targeting Tmem63b and Piezo2 in C-fiber low-threshold mechanoreceptors: Limitation of Vglut3-IRES-Cre.Biophysical journal · 2025Article
- Article
- The brain-heart axis: integrative cooperation of neural, mechanical and biochemical pathways.Nature reviews. Cardiology · 2025Review
- Sound-evoked tonic motility of cochlear outer hair cells in mice with stereociliary defects.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Mechanosensitive Ion Channels: The Unending Riddle of Mechanotransduction.Bioelectricity · 2025Review
- The Diverse Functions of the Calcium- and Integrin-Binding Protein Family.International journal of molecular sciences · 2025Review
- Structural insights into calcium-dependent CIB2-TMC1 interaction in hair cell mechanotransduction.Communications biology · 2025Article
- Molecular Insights Into the Sensory Adaption of the Cave-Dwelling LeechEcology and evolution · 2025Article
- Review of sensory systems deployed by epidermal keratinocytes.Frontiers in cell and developmental biology · 2025Review
- Mechanisms of mechanotransduction and physiological roles of PIEZO channels.Nature reviews. Molecular cell biology · 2024Review
- Localization of Piezo 1 and Piezo 2 in Lateral Line System and Inner Ear of Zebrafish (International journal of molecular sciences · 2024Article
- Sensory transduction in auditory hair cells-PIEZOs can't touch this.The Journal of general physiology · 2024Article
- Mechanoregulation and function of calponin and transgelin.Biophysics reviews · 2024Review
- Piezo1: the key regulators in central nervous system diseases.Frontiers in cellular neuroscience · 2024Review
Corrections and comments
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Authors and funding
24 authors at 6 institutions in 2 countries.
Jeong Han Lee *Department of Physiology and Cell Biology, School of Medicine, University of Nevada, Reno, NV, 89557, USA.
Maria C Perez-Flores *Department of Physiology and Cell Biology, School of Medicine, University of Nevada, Reno, NV, 89557, USA.ORCID 0000-0002-2166-5648
Seojin ParkDepartment of Physiology and Cell Biology, School of Medicine, University of Nevada, Reno, NV, 89557, USA.ORCID 0009-0007-5404-2862
Hyo Jeong KimDepartment of Physiology and Cell Biology, School of Medicine, University of Nevada, Reno, NV, 89557, USA.
Yingying ChenDepartment of Physiology and Cell Biology, School of Medicine, University of Nevada, Reno, NV, 89557, USA.ORCID 0000-0001-5890-5302
Mincheol KangDepartment of Physiology and Cell Biology, School of Medicine, University of Nevada, Reno, NV, 89557, USA.ORCID 0009-0005-2039-5163
Jennifer KersigoDepartment of Biology, University of Iowa, Iowa City, IA, USA.
Jinsil ChoiDepartment of Physiology and Cell Biology, School of Medicine, University of Nevada, Reno, NV, 89557, USA.
Phung N ThaiDivision of Cardiovascular Medicine, Department of Internal Medicine, University of California, Davis, CA, 95616, USA.ORCID 0000-0001-7344-150X
Ryan L WoltzDivision of Cardiovascular Medicine, Department of Internal Medicine, University of California, Davis, CA, 95616, USA.ORCID 0000-0002-0446-2478
Dolores Columba Perez-FloresDepartment of Physiology and Cell Biology, School of Medicine, University of Nevada, Reno, NV, 89557, USA.
Guy PerkinsNational Center for Microscopy and Imaging Research, University of California San Diego, La Jolla, CA, 92093, USA.
Choong-Ryoul SihnDepartment of Physiology and Cell Biology, School of Medicine, University of Nevada, Reno, NV, 89557, USA.
Pauline TrinhDivision of Cardiovascular Medicine, Department of Internal Medicine, University of California, Davis, CA, 95616, USA.
Xiao-Dong ZhangDivision of Cardiovascular Medicine, Department of Internal Medicine, University of California, Davis, CA, 95616, USA.
Padmini SirishDivision of Cardiovascular Medicine, Department of Internal Medicine, University of California, Davis, CA, 95616, USA.ORCID 0000-0002-9216-279X
Yao DongDepartment of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, 1089 VM3B, Davis, CA, 95616, USA.
Wayne Wei FengDepartment of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, 1089 VM3B, Davis, CA, 95616, USA.ORCID 0000-0003-1645-8238
Isaac N PessahDepartment of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, 1089 VM3B, Davis, CA, 95616, USA.
Rose E DixonDepartment of Physiology & Membrane Biology, Tupper Hall, One Shields Avenue, Davis, CA, 95616, USA.ORCID 0000-0003-0655-690X
Bernd SokolowskiDepartment of Otolaryngology-Head and Neck Surgery, Morsani College of Medicine, University of South Florida, Tampa, FL, 33612, USA.ORCID 0000-0003-2089-7663
Bernd FritzschDepartment of Biology, University of Iowa, Iowa City, IA, USA.ORCID 0000-0002-4882-8398
Nipavan ChiamvimonvatDivision of Cardiovascular Medicine, Department of Internal Medicine, University of California, Davis, CA, 95616, USA.
Ebenezer N YamoahDepartment of Physiology and Cell Biology, School of Medicine, University of Nevada, Reno, NV, 89557, USA. enyamoah@gmail.com.ORCID 0000-0002-9797-085X
University of Nevada, Reno · USUniversity of California, Davis · USUniversity of Iowa · USUniversity of California San Diego · USUniversity of South Florida · USVA Northern California Health Care System · US
Funding
Transgenic Animal Genotyping and Phenotyping CoreP20GM130459 · NIGMS · UNIVERSITY OF NEVADA RENO · PI Nathan Grainger · 2019 to 2026
$20.3MStructural Analyses CoreP01AG051443 · NIA · UNIVERSITY OF NEVADA RENO · PI RUBIO-VALERO, MARIA-EULALIA · 2016 to 2025
$15.5MFunctional Interactions of Cardiac Ion ChannelsR01HL085844 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CHIAMVIMONVAT, NIPAVAN · 2007 to 2025
$7.3MTranslational Study of Cardiac DysfunctionR01HL085727 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CHIAMVIMONVAT, NIPAVAN, SIRISH, PADMINI · 2008 to 2022
$5.7MInner ear ion channels in healthy and diseased conditionsR01DC016099 · NIDCD · UNIVERSITY OF NEVADA RENO · PI EBENEZER N YAMOAH · 2017 to 2026
$4.7MPotassium Homeostasis in the Inner EarR01DC007592 · NIDCD · UNIVERSITY OF NEVADA RENO · PI YAMOAH, EBENEZER N · 2005 to 2014
$4.5MPROPERTIES AND FUNCTIONS OF CA CHANNELS IN HAIR CELLSR01DC003826 · NIDCD · UNIVERSITY OF NEVADA RENO · PI YAMOAH, EBENEZER N · 2000 to 2014
$4.4MMolecular choreography of CaV1.2 channels in the aging myocardiumR01AG063796 · NIA · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Rose Ellen Dixon · 2019 to 2026
$3.1MMechanisms of Growth Factor Responsiveness in the Aging Auditory SystemR01AG060504 · NIA · UNIVERSITY OF NEVADA RENO · PI FRITZSCH, BERND, YAMOAH, EBENEZER N · 2018 to 2022
$2.5MLipid regulation of Cardiac Excitation-Contraction couplingR01HL159304 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI DIXON, ROSE ELLEN · 2022 to 2025
$2.4MDecoding the enigma of cardiac amplificationR01HL137228 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CHIAMVIMONVAT, NIPAVAN · 2017 to 2020
$2.2MCalcium-dependent functions in Hair Cells and Spiral Ganglion NeuronsR01DC015135 · NIDCD · UNIVERSITY OF NEVADA RENO · PI GRATTON, MICHAEL ANNE NMI, YAMOAH, EBENEZER N · 2016 to 2020
$2.1MAmerican Heart AssociationBLRD VA I01 BX000576CSRD VA I01 CX001490Harold S. Geneen Charitable Trust Awards Program for Coronary Heart DiseaseNational Science FoundationNCRR NIH HHS S10 RR022498NHLBI NIH HHS F31 HL170698NHLBI NIH HHS F32 HL151130NHLBI NIH HHS R01 HL085727NHLBI NIH HHS R01 HL085844NHLBI NIH HHS R01 HL137228NHLBI NIH HHS R01 HL158961NHLBI NIH HHS R01 HL159304NHLBI NIH HHS R56 HL138392NHLBI NIH HHS R56 HL167932NIA NIH HHS P01 AG051443NIA NIH HHS R01 AG060504NIA NIH HHS R01 AG063796NIDCD NIH HHS R01 DC003826NIDCD NIH HHS R01 DC007592NIDCD NIH HHS R01 DC015135NIDCD NIH HHS R01 DC015252NIDCD NIH HHS R01 DC016099NIGMS NIH HHS P20 GM130459
Abstract
The inner ear is the hub where hair cells (HCs) transduce sound, gravity, and head acceleration stimuli to the brain. Hearing and balance rely on mechanosensation, the fastest sensory signals transmitted to the brain. The mechanoelectrical transducer (MET) channel is the entryway for the sound-balance-brain interface, but the channel-complex composition is not entirely known. Here, we report that the mouse utilizes Piezo1 (Pz1) and Piezo2 (Pz2) isoforms as MET-complex components. The Pz channels, expressed in HC stereocilia, and cell lines are co-localized and co-assembled with MET complex partners. Mice expressing non-functional Pz1 and Pz2 at the ROSA26 locus have impaired auditory and vestibular traits that can only be explained if the Pzs are integral to the MET complex. We suggest that Pz subunits constitute part of the MET complex and that interactions with other MET complex components yield functional MET units to generate HC MET currents.
Indexed as
Ear, InnerHair Cells, Auditory, InnerAnimalsHair Cells, AuditoryHearingIon ChannelsMammalsMechanotransduction, CellularMiceStereociliaIon ChannelsPiezo1 protein, mouse
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