ArticleNature communications2024
Host- plasmid network structure in wastewater is linked to antimicrobial resistance genes.
Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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Who cites it
22 citing papers in PubMed.
- Plasmid-Host Networks Reveal Persistent Mobile Elements Across Wastewater Treatment.Nature communications · 2026Article
- Invasive plasmids as ecosystem engineers-from mechanism to application.Essays in biochemistry · 2026Review
- Plasmid-mediated antimicrobial resistance across One Health sectors: transmission dynamics and surveillance needs.mSphere · 2026Review
- Assessing resistome host range across water reclamation in three geographically distinct communities using Hi-C sequencing.Applied and environmental microbiology · 2026Article
- The interplay between ecological networks drives host-plasmid community dynamics.PLoS computational biology · 2026Article
- Genomic Epidemiology of Antibiotic-Resistant Bacteria Sampled from Metropolitan Wastewater.Microorganisms · 2026Article
- Horizontal and vertical gene transfer shape the plasmid host range in surface-associated microbial systems.iScience · 2026Article
- A Cautionary Case for Host Assignment Based on Broad Environmental blaEnvironmental microbiology reports · 2026Article
- TheInternational journal of molecular sciences · 2026Review
- Recovery and microbial host assignment of mobile genetic elements in complex microbiomes: insights from a spiked gut sample.mSystems · 2026Article
- Proof-of-concept of host attribution of antimicrobial resistance genes using wastewater Hi-C metagenome sequencing.Journal of water and health · 2026Article
- Microbial interactions as the key to understanding and controlling environmental spread of antibiotic resistance genes.npj antimicrobials and resistance · 2025Article
- Longitudinal replicated metagenomic analysis of biosolids-amended soils reveals enrichment of ARGs, virulence factors, and ESKAPE pathogens.npj antimicrobials and resistance · 2025Article
- Colistin resistance plasmids dually enhance bacterial virulence and antibiotic resistance via surface polysaccharide biosynthesis.Nature communications · 2025Article
- Circling in on plasmids: benchmarking plasmid detection and reconstruction tools for short-read data from diverse species.Briefings in bioinformatics · 2025Article
- Mapping the underlying drivers of resistome risk across diverse environments.Research square · 2025Article
- Scaling laws of bacterial and archaeal plasmids.Nature communications · 2025Article
- Unveiling plasmid diversity and functionality in pristine groundwater.Environmental microbiome · 2025Article
- Global analysis of the metaplasmidome: ecological drivers and spread of antibiotic resistance genes across ecosystems.Microbiome · 2025Article
- Tracing the evolution: the rise ofmSystems · 2025Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
As mobile genetic elements, plasmids are central for our understanding of antimicrobial resistance spread in microbial communities. Plasmids can have varying fitness effects on their host bacteria, which will markedly impact their role as antimicrobial resistance vectors. Using a plasmid population model, we first show that beneficial plasmids interact with a higher number of hosts than costly plasmids when embedded in a community with multiple hosts and plasmids. We then analyse the network of a natural host-plasmid wastewater community from a Hi-C metagenomics dataset. As predicted by the model, we find that antimicrobial resistance encoding plasmids, which are likely to have positive fitness effects on their hosts in wastewater, interact with more bacterial taxa than non-antimicrobial resistance plasmids and are disproportionally important for connecting the entire network compared to non- antimicrobial resistance plasmids. This highlights the role of antimicrobials in restructuring host-plasmid networks by increasing the benefits of antimicrobial resistance carrying plasmids, which can have consequences for the spread of antimicrobial resistance genes through microbial networks. Furthermore, that antimicrobial resistance encoding plasmids are associated with a broader range of hosts implies that they will be more robust to turnover of bacterial strains.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.