Evidence map›Paper›PMID 38228181›Full record

ArticleJournal of the Royal Society, Interface2024

A continuum mechanical model of cell motion driven by a biphasic traction stress.

Rohan Abeyaratne, Prashant K Purohit

Open access · bronzeAbstract read
In one paragraph

Article in Journal of the Royal Society, Interface, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Rohan AbeyaratneDepartment of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.ORCID 0000-0003-2912-1538
Prashant K PurohitDepartment of Mechanical Engineering and Applied Mechanics, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0002-1939-907X
Massachusetts Institute of Technology · USUniversity of Pennsylvania · US

Funding

Mechanisms of mechano-chemical rupture of blood clots and thrombiR01HL148227 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI PUROHIT, PRASHANT KISHORE · 2020 to 2023
$2.5M
NHLBI NIH HHS R01 HL148227
6 · The paper itself

Abstract

The aim of this paper is to place the cell locomotion problem within the general framework of classical continuum mechanics, and while doing so, to account for the deformation of the actin network in the cytoskeleton; the myosin activity on the lamellum including its effect on depolymerization at the trailing edge; model the stress-dependent driving forces and kinetic laws controlling polymerization at the leading edge, depolymerization at the trailing edge and ATP hydrolysis consistently with the dissipation inequality; and, based on the observations in Gardel

Indexed as

ActinsTractionActin CytoskeletonCell MovementCytoskeletonPseudopodiaActinsactin treadmillingcell locomotioncontinuum mechanics

Identifiers

PMID38228181
PMCPMC10791542
OpenAlexW4390929570

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.