Evidence map›Paper›PMID 38228152›Full record

ArticleCell reports methods2024

Enhanced detection of antigen-specific T cells by a multiplexed AIM assay.

Audrée Lemieux, Gérémy Sannier, Alexandre Nicolas, Manon Nayrac, Gloria-Gabrielle Delgado, Rose Cloutier, Nathalie Brassard, Mélanie Laporte, Mélina Duchesne, Alina Maria Sreng Flores and 4 more

Abstract read
In one paragraph

Article in Cell reports methods, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. CD4Sensors (Basel, Switzerland) · 2026
    Pooled it
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  18. Advanced Identification of Trypanosoma cruzi-Specific CD4Methods in molecular biology (Clifton, N.J.) · 2026
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Audrée LemieuxCentre de Recherche du CHUM, Montreal, QC H2X 0A9, Canada; Département de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montreal, QC H2X 0A9, Canada.
Gérémy SannierCentre de Recherche du CHUM, Montreal, QC H2X 0A9, Canada; Département de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montreal, QC H2X 0A9, Canada.
Alexandre NicolasCentre de Recherche du CHUM, Montreal, QC H2X 0A9, Canada; Département de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montreal, QC H2X 0A9, Canada.
Manon NayracCentre de Recherche du CHUM, Montreal, QC H2X 0A9, Canada; Département de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montreal, QC H2X 0A9, Canada.
Gloria-Gabrielle DelgadoCentre de Recherche du CHUM, Montreal, QC H2X 0A9, Canada.
Rose CloutierCentre de Recherche du CHUM, Montreal, QC H2X 0A9, Canada.
Nathalie BrassardCentre de Recherche du CHUM, Montreal, QC H2X 0A9, Canada.
Mélanie LaporteCentre de Recherche du CHUM, Montreal, QC H2X 0A9, Canada.
Mélina DuchesneCentre de Recherche du CHUM, Montreal, QC H2X 0A9, Canada.
Alina Maria Sreng FloresCentre de Recherche du CHUM, Montreal, QC H2X 0A9, Canada.
Andrés FinziCentre de Recherche du CHUM, Montreal, QC H2X 0A9, Canada; Département de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montreal, QC H2X 0A9, Canada.
Olivier TastetCentre de Recherche du CHUM, Montreal, QC H2X 0A9, Canada.
Mathieu DubéCentre de Recherche du CHUM, Montreal, QC H2X 0A9, Canada. Electronic address: mathieu.dube.chum@ssss.gouv.qc.ca.
Daniel E KaufmannCentre de Recherche du CHUM, Montreal, QC H2X 0A9, Canada; Consortium for HIV/AIDS Vaccine Development (CHAVD), La Jolla, CA, USA; Département de Médecine, Université de Montréal, Montreal, QC H2X 0A9, Canada; Division of Infectious Diseases, Department of Medicine, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Electronic address: daniel.kaufmann@chuv.ch.

Funding

Identification of neutralizing epitopes on SARS-CoV-2 spike for design of vaccines and small-molecule antiviralsUM1AI144462 · NIAID · SCRIPPS RESEARCH INSTITUTE, THE · PI BURTON, DENNIS R. · 2019 to 2025
$201.6M
NIAID NIH HHS UM1 AI144462
6 · The paper itself

Abstract

Broadly applicable methods to identify and characterize antigen-specific CD4

Indexed as

CD4-Positive T-LymphocytesCD8-Positive T-LymphocytesAntigensCytomegalovirusTumor Necrosis Factor Receptor Superfamily, Member 9AntigensTumor Necrosis Factor Receptor Superfamily, Member 94-1BB (CD137)activation-induced marker (AIM) assayAntigen-specific CD4(+) T cellsantigen-specific CD8(+) T cellsCD40L (CD154)CD69CP: Immunologyflow cytometryinfection-induced T cell responsesOX40 (CD134)vaccine-induced T cell responses

Identifiers

PMID38228152
PMCPMC10831934

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.