Evidence map›Paper›PMID 38227965›Full record

ArticleACS nano2024

Systemic Delivery of Paclitaxel by Find-Me Nanoparticles Activates Antitumor Immunity and Eliminates Tumors.

Soonbum Kwon, Fanfei Meng, Hassan Tamam, Hytham H Gadalla, Jianping Wang, Boyang Dong, Amber S Hopf Jannasch, Timothy L Ratliff, Yoon Yeo

Open access · greenAbstract read
In one paragraph

Article in ACS nano, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
8.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.

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  15. Timely administration of drug combination improves chemoimmunotherapy of an immune-cold tumor.Journal of controlled release : official journal of the Controlled Release Society · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 2 countries.

Soonbum KwonDepartment of Industrial and Molecular Pharmaceutics, Purdue University, 575 Stadium Mall Drive, West Lafayette, Indiana 47907, United States.ORCID 0000-0001-7425-700X
Fanfei MengDepartment of Industrial and Molecular Pharmaceutics, Purdue University, 575 Stadium Mall Drive, West Lafayette, Indiana 47907, United States.ORCID 0000-0002-4231-7888
Hassan TamamDepartment of Industrial and Molecular Pharmaceutics, Purdue University, 575 Stadium Mall Drive, West Lafayette, Indiana 47907, United States.ORCID 0000-0003-4691-0141
Hytham H GadallaDepartment of Industrial and Molecular Pharmaceutics, Purdue University, 575 Stadium Mall Drive, West Lafayette, Indiana 47907, United States.ORCID 0000-0002-6919-5278
Jianping WangDepartment of Industrial and Molecular Pharmaceutics, Purdue University, 575 Stadium Mall Drive, West Lafayette, Indiana 47907, United States.
Boyang DongDepartment of Industrial and Molecular Pharmaceutics, Purdue University, 575 Stadium Mall Drive, West Lafayette, Indiana 47907, United States.
Amber S Hopf JannaschMetabolite Profiling Facility, Bindley Bioscience Center, Purdue University, 1203 Mitch Daniels Boulevard, West Lafayette, Indiana 47907, United States.
Timothy L RatliffPurdue University Institute for Cancer Research, 201 South University Street, West Lafayette, Indiana 47907, United States.
Yoon YeoDepartment of Industrial and Molecular Pharmaceutics, Purdue University, 575 Stadium Mall Drive, West Lafayette, Indiana 47907, United States.ORCID 0000-0001-9505-7701
Purdue University West Lafayette · US

Funding

Transgenic Mouse Core Facility Shared Resource (TMCF-SR)P30CA023168 · NCI · PURDUE UNIVERSITY WEST LAFAYETTE · PI Andrea L Kasinski · 1985 to 2026
$43.4M
Quality Assurance and Quality Control Project Management: Improving Submissions and Study Conduct in the Human Subjects Research Prior Approval ProcessUL1TR002529 · NCATS · INDIANA UNIVERSITY INDIANAPOLIS · PI MOE, SHARON M, WIEHE, SARAH ELIZABETH · 2018 to 2022
$27.2M
Systemic delivery of siRNA by Nanosac for checkpoint blockade immunotherapy of head and neck squamous cell cancerR01CA258737 · NCI · PURDUE UNIVERSITY · PI KRON, STEPHEN J., YEO, YOON · 2021 to 2024
$2.3M
Chemotherapy delivery with nanoparticles for targeted induction of immunogenic cell deathR01CA232419 · NCI · PURDUE UNIVERSITY · PI YEO, YOON · 2018 to 2022
$2.0M
NCATS NIH HHS UL1 TR002529NCI NIH HHS P30 CA023168NCI NIH HHS R01 CA232419NCI NIH HHS R01 CA258737
6 · The paper itself

Abstract

Local delivery of immune-activating agents has shown promise in overcoming an immunosuppressive tumor microenvironment (TME) and stimulating antitumor immune responses in tumors. However, systemic therapy is ultimately needed to treat tumors that are not readily locatable or accessible. To enable systemic delivery of immune-activating agents, we employ poly(lactic-

Indexed as

NanoparticlesNeoplasmsAdenosine TriphosphateCell Line, TumorHumansPaclitaxelPolylactic Acid-Polyglycolic Acid CopolymerTumor MicroenvironmentAdenosine TriphosphatePaclitaxelPolylactic Acid-Polyglycolic Acid Copolymeradenosine triphosphatechemoimmunotherapyimmunogenic cell deathpaclitaxelPLGA nanoparticlessystemic delivery

Identifiers

PMID38227965
PMCPMC11025439
OpenAlexW4390901490

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.